L-cysteine-induced brain damage in adult rats

Experimental and Toxicologic Pathology

Volumn 56, Issue 1-2, 2004, Pages 45-52

  Sawamoto, Osamu ^a   Hagiwara, Rika ^a   Kurisu, Kazunobu ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Amino acid; Apoptosis; Brain; L Cysteine; Neuronal death; Rat; Toxicity

Indexed keywords

CYSTEINE; DNA;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INJURY; CELL PROLIFERATION; CEREBELLUM CORTEX; CONTROLLED STUDY; GLIA CELL; GRANULAR CELL; HISTOPATHOLOGY; MALE; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; PHAGOCYTE; RAT; TIME;

EID: 8444249671     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2004.05.003     Document Type: Article

References (30)

1. Ankarcrona M, Dypbukt JM, Bonfoco E, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995;15:961-73.
2. Benzi G, Arrigoni E, Dagani F, et al. Cerebral energy state during or after hypoxia and complete or incomplete ischemia. J Appl Physiol 1978;45:312-9.
3. Dringen R, Pfeiffer B, Hamprecht B. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci 1999;19:562-9.
4. Eto K, Yasutake A, Kuwana T, et al. Methylmercury poisoning in common marmosets-a study of selective vulnerability within the cerebral cortex. Toxicol Pathol 2001;29:565-73.
5. Graham DI. Pathology of hypoxic brain damage in man. J Clin Pathol Suppl (R Coll Pathol) 1977;11:170-80.
6. Hayashi T, Sakurai M, Abe K, et al. Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia. Stroke 1998;29:1007-13.
7. Heafield MT, Fearn S, Steventon GB, et al. Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease. Neurosci Lett 1990;110:216-20.
8. Janaky R, Varga V, Hermann A, et al. Mechanisms of L-cysteine neurotoxicity. Neurochem Res 2000;25:1397-405.
9. Juarez BI, Martinez ML, Montante M, et al. Methylmercury increases glutamate extracellular levels in frontal cortex of awake rats. Neurotoxicol Teratol 2002;24:767-71.
10. Karlsen RL, Grofova I, Malthe-Sorenssen D, et al. Morphological changes in rat brain induced by L-cysteine injection in newborn animals. Brain Res 1981;208:167-80.
11. Keller HJ, Do KQ, Zollinger M, et al. Cysteine: depolarization-induced release from rat brain in vitro. J Neurochem 1989;52:1801-6.
12. Klingman JG, Choi DW. Toxicity of sulfur-containing amino acids on cultured cortical neurons. Neurology 1989;39(Suppl. 1):242.
13. Kranich O, Hamprecht B, Dringen R. Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain. Neurosci Lett 1996;219:211-4.
14. Lehmann A, Hagberg H, Orwar O, et al. Cysteine sulphinate and cysteate: mediators of cysteine toxicity in the neonatal rat brain? Eur J Neurosci 1993;5:1398-412.
15. Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993;24:2002-9.
16. Mathisen GA, Fonnum F, Paulsen RE. Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells. Neurochem Res 1996;21:293-8.
17. Mori F, Tanji K, Wakabayashi K. Thiophene, a sulfur-containing heterocyclic hydrocarbon, causes widespread neuronal degeneration in rats. Neuropathology 2000;20:283-8.
18. Nagashima K. A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis. Toxicol Pathol 1997;25:624-31.
19. Olney JW. Role of excitotoxins in developmental neuropathology. APMIS Suppl 1993;40:103-12.
20. Olney JW, Zorumski C, Price MT, et al. L-Cysteine, a bicarbonate- sensitive endogenous excitotoxin. Science 1990;248:596-9.
21. Plum F. What causes infarction in ischemic brain?: The Robert Wartenberg Lecture. Neurology 1983;33:222-33.
22. Portera-Cailliau C, Price DL, Martin LJ. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. J Comp Neurol 1997;378:88-104.
23. Sagara J, Miura K, Bannai S. Maintenance of neuronal glutathione by glial cells. J Neurochem 1993;61:1672-6.
24. Sawamoto O, Kyo S, Kaneda S, et al. Four-week intravenous repeated dose toxicity study of L-cysteine in male rats. J Toxicol Sci 2003;28:95-107.
25. Schurr A, West CA, Heine MF, et al. The neurotoxicity of sulfur-containing amino acids in energy-deprived rat hippocampal slices. Brain Res 1993;601:317-20.
26. Schwartz LM, Smith SW, Jones ME, et al. Do all programmed cell deaths occur via apoptosis? Proc Natl Acad Sci USA 1993;90:980-4.
27. Shapre LG, Olney JW, Ohlendorf C, et al. Brain damage and associated behavioral deficits following the administration of L-cysteine to infant rats. Pharmacol Biochem Behav 1975;3:291-8.
28. Slivka A, Cohen G. Brain ischemia markedly elevates levels of the neurotoxic amino acid, cysteine. Brain Res 1993;608:33-7.
29. Tan S, Wood M, Maher P. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem 1998;71:95-105.
30. Zangerle L, Cuenod M, Winterhalter KH, et al. Screening of thiol compounds: depolarization-induced release of glutathione and cysteine from rat brain slices. J Neurochem 1992;59:181-9.