Unique TCRDV1-positive lymphocytes that infiltrate colonic neoplasia originate from a selected cell population present in the intestinal mucosa and the peripheral blood

Scandinavian Journal of Immunology

Volumn 60, Issue 5, 2004, Pages 529-534

  Coscas, D ^a   Chowers, M ^b,c   Levite, M ^c,d   Amariglio, N ^c,e   Lang, A ^a,c   Barshack, I ^c,e   Bar Meir, S ^a,c   Chowers, Y ^a,c,e  

^a Department of Gastroenterology ^*  (Israel)

^b MEIR MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^e SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR DELTA CHAIN;

ADENOMATOUS POLYP; ANTIGEN EXPRESSION; ARTICLE; BLOOD; CANCER IMMUNOLOGY; CELL POPULATION; CLINICAL ARTICLE; COLON ADENOMA; COLON CARCINOMA; COLON MUCOSA; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR ASSOCIATED LEUKOCYTE;

CARCINOMA; COLONIC NEOPLASMS; COMPLEMENTARITY DETERMINING REGIONS; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTES; RECEPTORS, ANTIGEN, T-CELL; RNA, MESSENGER;

EID: 8444240751     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0300-9475.2004.01510.x     Document Type: Article

References (17)

1. Deusch K, Luling F, Reich K. A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/ delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol 1991;21:1053-9.
2. - and V delta 1/J delta 1+ phenotypes are increased in coeliac disease. Scand J Immunol 1989;30:665-72.
3. Chowers Y, Holtmeier W, Harwood J. The V delta 1 T cell receptor repertoire in human small intestine and colon. J Exp Med 1994;180:183-90.
4. Holtmeier W, Chowers Y, Lumeng A. The delta T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage. J Clin Invest 1995;96:1108-17.
5. Maeurer MJ, Martin D, Walter W. Human intestinal Vdelta1+ lymphocytes recognize tumor cells of epithelial origin. J Exp Med 1996;183:1681-96.
6. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press, 1989:6-24.
7. Zocchi MR, Ferrarini M, Rugarli C. Selective lysis of the autologous tumor by delta TCS1+ gamma/delta+ tumor-infiltrating lymphocytes from human lung carcinomas. Eur J Immunol 1990;20:2685-9.
8. Kowalczyk D, Skorupski W, Drews M. Different pattern of T cell receptor delta gene rearrangement in tumour-infiltrating lymphocytes and peripheral blood in patients with solid tumors. Cancer Immunol Immunocher 1994;39:275-8.
9. Olive C, Nicol D, Falk MC. Characterisation of gamma delta T cells in renal cell carcinoma patients by polymerase chain reaction analysis of T cell receptor transcripts. Cancer Immunol Immunother 1997;44:27-34.
10. Kitayama J, Atomi Y, Nagawa H. Functional analysis of TCR gamma delta+ T cells in tumour-infiltrating lymphocytes (TIL) of human pancreatic cancer. Clin Exp Immunol 1993;93:442-7.
11. Smyth MJ, Trapani JA. Lymphocyte-mediated immunosurveillance of epithelial cancers? Trends Immunol 2001;22:409-11.
12. Spada FM, Grant EP, Peters PJ. Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity. J Exp Med 2000;191:937-48.
13. Groh V, Rhinehart R, Secrist H. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICE. Proc Nad Acad Sci USA 1999;96:6879-84.
14. Groh V, Steinle A, Bauer S, Spies T. Recognition of stress-induced MHC molecules by intestinal epithelial gamma delta T cells. Science 1998;279:1737-40.
15. Steinle A, Groh V, Spies T. Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules. Proc Natl Acad Sci USA 1998;95:12510-5.
16. Rock EP, Sibbald PR, Davis MM. CDR3 length in antigen-specific immune receptors. J Exp Med 1994;179:323-8.
17. Schild H, Mavaddat N, Litzenberger C. The nature of major histocompatibility complex recognition by gamma delta T cells. Cell 1994;79:29-37.