The interferon gamma gene in celiac disease: Augmented expression correlates with tissue damage but no evidence for genetic susceptibility

Journal of Autoimmunity

Volumn 23, Issue 2, 2004, Pages 183-190

  Wapenaar, Martin C ^a   Van Belzen, Martine J ^a   Fransen, Justin H ^a   Fariña Sarasqueta, Aranzazu ^a   Houwen, Roderick H J ^a   Meijer, Jos W R ^b   Mulder, Chris J J ^b,c   Wijmenga, Cisca ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RIJNSTATE HOSPITAL   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Celiac disease; Gene expression; Genetics; Interferon gamma; Intestinal mucosa

Indexed keywords

GAMMA INTERFERON;

ADOLESCENT; ADULT; AGED; ARTICLE; CELIAC DISEASE; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DUODENUM BIOPSY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE OVEREXPRESSION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; ATROPHY; CELIAC DISEASE; DISEASE PROGRESSION; DUODENUM; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INHERITANCE PATTERNS; INTERFERON TYPE II; LINKAGE (GENETICS); MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 8444221894     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaut.2004.05.004     Document Type: Article

References (30)

1. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology. 119:2000;234-242
2. Marsh M.N. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology. 102:1992;330-354
3. Fasano A., Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 120:2001;636-651
4. Green P.H., Jabri B. Coeliac disease. Lancet. 362:2003;383-391
5. Sollid L.M. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol. 2:2002;647-655
6. van de Wal Y., Kooy Y., van Veelen P., Pena S., Mearin L., Papadopoulos G., et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol. 161:1998;1585-1588
7. Molberg O., McAdam S.N., Korner R., Quarsten H., Kristiansen C., Madsen L., et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med. 4:1998;713-717
8. Kontakou M., Sturgess R.P., Przemioslo R.T., Limb G.A., Nelufer J.M., Ciclitira P.J. Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation. Gut. 35:1994;1037-1041
9. Nilsen E.M., Jahnsen F.L., Lundin K.E., Johansen F.E., Fausa O., Sollid L.M., et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology. 115:1998;551-563
10. Lahat N., Shapiro S., Karban A., Gerstein R., Kinarty A., Lerner A. Cytokine profile in coeliac disease. Scand J Immunol. 49:1999;441-446
11. Forsberg G., Hernell O., Melgar S., Israelsson A., Hammarstrom S., Hammarstrom M.L. Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology. 123:2002;667-678
12. Hansson T., Dannaeus A., Klareskog L. Cytokine-producing cells in peripheral blood of children with coeliac disease secrete cytokines with a type 1 profile. Clin Exp Immunol. 116:1999;246-250
13. Przemioslo R.T., Lundin K.E., Sollid L.M., Nelufer J., Ciclitira P.J. Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody. Gut. 36:1995;874-879
14. Olaussen R.W., Johansen F.E., Lundin K.E., Jahnsen J., Brandtzaeg P., Farstad I.N. Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease. Scand J Immunol. 56:2002;652-664
15. Guy-Grand D., DiSanto J.P., Henchoz P., Malassis-Seris M., Vassalli P. Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal. Eur J Immunol. 28:1998;730-744
16. Pravica V., Asderakis A., Perrey C., Hajeer A., Sinnott P.J., Hutchinson I.V. In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene. Eur J Immunogenet. 26:1999;1-3
17. Pena A.S., Wijmenga C. Genetic factors underlying gluten-sensitive enteropathy. Curr Allergy Asthma Rep. 1:2001;526-533
18. Van Belzen M.J., Meijer J.W., Sandkuijl L.A., Bardoel A.F., Mulder C.J., Pearson P.L., et al. A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology. 125:2003;1032-1041
19. Report of a working group of the United European Gastroenterology Week in Amsterdam. When is a coeliac a coeliac? Eur J Gastroenterol Hepatol. 13:2001;1123-1128
20. Goerres M.S., Meijer J.W., Wahab P.J., Kerckhaert J.A., Groenen P.J., Van Krieken J.H., et al. Azathioprine and prednisone combination therapy in refractory coeliac disease. Aliment Pharmacol Ther. 18:2003;487-494
21. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:2001;402-408
22. Kruglyak L., Lander E.S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet. 57:1995;439-454
23. Awata T., Matsumoto C., Urakami T., Hagura R., Amemiya S., Kanazawa Y. Association of polymorphism in the interferon gamma gene with IDDM. Diabetologia. 37:1994;1159-1162
24. Jahromi M., Millward A., Demaine A. A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes. J Interferon Cytokine Res. 20:2000;187-190
25. Khani-Hanjani A., Lacaille D., Hoar D., Chalmers A., Horsman D., Anderson M., et al. Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of rheumatoid arthritis. Lancet. 356:2000;820-825
26. Vandenbroeck K., Opdenakker G., Goris A., Murru R., Billiau A., Marrosu M.G. Interferon-gamma gene polymorphism-associated risk for multiple sclerosis in Sardinia. Ann Neurol. 44:1998;841-842
27. Goris A., Epplen C., Fiten P., Andersson M., Murru R., Sciacca F.L., et al. Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease. J Interferon Cytokine Res. 19:1999;1037-1046
28. Seegers D., Borm M.E., van Belzen M.J., Mulder C.J., Bailing J., Crusius J.B., et al. IL12B and IRF1 gene polymorphisms and susceptibility to celiac disease. Eur J Immunogenet. 30:2003;421-425
29. Ryan B.M., Kelleher D. Refractory celiac disease. Gastroenterology. 119:2000;243-251
30. Diosdado B., Wapenaar M.C., Franke L., Duran K.J., Goerres M.J., Hadithi M., et al. A microarray screen for novel candidate genes in coeliac disease pathogenesis. Gut. 53:2004;944-951