Identification of an antioxidant small-molecule with broad-spectrum antiviral activity

Antiviral Research

Volumn 93, Issue 1, 2012, Pages 23-29

  Panchal, Rekha G ^a   Reid, St Patrick ^a   Tran, Julie P ^a   Bergeron, Alison A ^a   Wells, Jay ^a   Kota, Krishna P ^b   Aman, Javad ^c   Bavari, Sina ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b PERKINELMER INC   (United States)

^c Integrated Biotherapeutics   (United States)

Author keywords

Antioxidant; Broad spectrum; Filoviruses; High content

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ANTIVIRUS AGENT; NSC 62914; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; SCAVENGER; TERT BUTYLHYDROQUINONE; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG SOLUBILITY; DRUG TARGETING; EBOLA VIRUS; FEMALE; FILOVIRUS; FILOVIRUS INFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LASSA VIRUS; MARBURG VIRUS; MOLECULAR LIBRARY; MOLECULE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RIFT VALLEY FEVER BUNYAVIRUS; SCAVENGING SYSTEM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; BENZHYDRYL COMPOUNDS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; EBOLAVIRUS; FREE RADICAL SCAVENGERS; HELA CELLS; HEMORRHAGIC FEVER, EBOLA; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MARBURG VIRUS DISEASE; MARBURGVIRUS; MICE; MICE, INBRED C57BL; PHENOLS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EBOLA VIRUS; LAKE VICTORIA MARBURGVIRUS; LASSA VIRUS; MARBURGVIRUS; MUS; PRIMATES; RIFT VALLEY FEVER VIRUS; VENEZUELAN EQUINE ENCEPHALITIS VIRUS;

EID: 84355166551     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2011.10.011     Document Type: Article

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