Enoxaparin dose adjustment is associated with low incidence of venous thromboembolic events in acute burn patients

Journal of Trauma - Injury, Infection and Critical Care

Volumn 71, Issue 6, 2011, Pages 1557-1561

  Lin, Hsin ^a   Faraklas, Iris ^a   Saffle, Jeffrey ^a   Cochran, Amalia ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Antifactor Xa; Burn; Enoxaparin; Intensive care unit; Venous thromboemoblism

Indexed keywords

BLOOD CLOTTING FACTOR 10A; ENOXAPARIN;

ADOLESCENT; ADULT; AGED; BODY SURFACE; BODY WEIGHT; BURN; BURN PATIENT; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; VENOUS THROMBOEMBOLISM;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BURN UNITS; BURNS; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENOXAPARIN; FACTOR XA; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INJECTIONS, SUBCUTANEOUS; INJURY SEVERITY SCORE; INTENSIVE CARE; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PRIMARY PREVENTION; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84355162922     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31823070f9     Document Type: Conference Paper

References (21)

1. Geerts WH, Heit JA, Clagett GP, et al. Prevention of venous thromboembolism. Chest. 2001;132S-175S. (Pubitemid 32162075)
2. Faucher L, Conlon K. Practice guideline for deep venous thrombosis prophylaxis in burns. J Burn Care Res. 2007;28:661-663. (Pubitemid 47442810)
3. Wibbenmeyer LA, Hoballah JJ, Amelon MJ, et al. The prevalence of venous thromboembolism of the lower extremity among thermally injured patients determined by duplex sonography. J Trauma. 2003;55: 1162-1167. (Pubitemid 38044138)
4. Harrington DT, Mozingo DW, Canicio L, Bird P, Jordan B, Goodwin CW. Thermally injured patients are at significant risk for thromboembolic complications. J Trauma. 2001;50:495-499. (Pubitemid 32259812)
5. Fecher AM, O'Mara MS, Goldfarb IW, et al. Analysis of deep vein thrombosis in burn patients. Burns. 2004;30:591-593. (Pubitemid 39092356)
6. Yogaratnam D, Smith BS, Angood PB, Gandhi PJ. Antifactor Xa levels in four patients with burn injury who received enoxaparin to prevent venous thromboembolism. Pharmacotherapy. 2004;24:1793-1799. (Pubitemid 39578964)
7. Lin H, Faraklas I, Cochran A, Saffle J. Enoxaparin and anti factor Xa levels in acute burn patients. J Burn Care Res. 2011;32:1-5.
8. Levin M, Planes A, Hirsh J, Goodyear M, Vochelle N, Gent M. The relationship between anti factor Xa level and clinical outcome in patients receiving enoxaparin low molecular weight heparin to prevent deep vein thrombosis after hip replacement. Thomb Haemost. 1989;62:940-944. (Pubitemid 20005007)
9. Cockcroft DW, Gault HM. Predication of creatinine clearance from serum creatinine. Nephron. 1976;16:31-41.
10. Priglinger U, Delle Karth G, Geppert A, et al. Prophylactic anticoagulation with enoxaparin: Is the subcutaneous route appropriate in the critically ill? Crit Care Med. 2003;31:1405-1409. (Pubitemid 36583851)
11. Dorffler-Melly J, de Jonge E, Pont AC, et al. Bioavailability of subcutaneous low-molecular weight heparin to patients on vasopressors. Lancet. 2002;359:849-850. (Pubitemid 34233758)
12. Bonate P. Pathophysiology and pharmacokinetics following burn injury. Clin Pharmacokinet. 1990;18:118-130. (Pubitemid 20104031)
13. Jaehde U, Fritz S. Clinical pharmacokinetics in patients with burns. Clin Pharmacokinet. 1995;29:15-28.
14. Hass C, Nelsen J, Raghavendran K, et al. Pharmacokinetics and pharmacodynamics of enoxaparin in multiple trauma patients. J Trauma. 2005;59:1336 -1343; discussion 1343-1344.
15. Scholten DJ, Hoedema RM, Scholten SE. A comparison of two different prophylactic dose regimens of low molecular weight heparin in bariatric surgery. Obes Surg. 2002;12:19-24. (Pubitemid 34155256)
16. Lott R, Uden D, Wargin W, Strate RG, Zaske DE. Correlation of predicted versus measured creatinine clearance values in burn patients. Am J Hosp Pharm. 1978;35:717-720.
17. Posluszny JA Jr, Gamelli RL. Anemia of theral injury: Combined acute blood loss anemia and anemia of critical illness. J Burn Care Res. 2010;31:229-242.
18. Wahl L, Brandt M, Ahrns K, et al. Venous thrombosis incidence in burn patients: preliminary results of a prospective study. J Nurn Care Rehabil. 2002;23:97-102. (Pubitemid 34242509)
19. Pannucci CJ, Osborne NH, Wahl WL. Venous thromboembolism in thermally injured patients: analysis of the national burn repository. J Burn Care Res. 2011;32:6-12.
20. Malinoski D, Jafari F, Ewing T, et al. Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients. J Trauma. 2010;68:874-880.
21. Amin AN, Girard F, Samama MM. Does ambulation modify venous thromboembolism risk in acutely ill medical patients? Thromb Haemost. 2010;104:1-7.