Preparation and properties of calcium phosphate cements incorporated gelatin microspheres and calcium sulfate dihydrate as controlled local drug delivery system

Journal of Materials Science: Materials in Medicine

Volumn 22, Issue 11, 2011, Pages 2487-2496

  Cai, Shu ^a   Zhai, Yujia ^a   Xu, Guohua ^b   Lu, Shanshan ^a   Zhou, Wei ^a   Ye, Xiaojian ^b  

^a TIANJIN UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BONE REPAIRING; CALCIUM PHOSPHATE BONE CEMENT; CALCIUM PHOSPHATE CEMENT; CALCIUM SULFATE DIHYDRATE; CANCELLOUS BONE; CEMENT PROPERTIES; COMPOSITE CEMENTS; CONTROL SETTINGS; DEGRADATION RATE; DEGRADATION STUDY; DRUG CARRIER; DRUG RELEASE; GELATIN MICROSPHERES; GENTAMICIN SULPHATES; LOCAL DRUG DELIVERY; MACRO-POROSITY; MACROPORES; MACROPOROUS; MODEL DRUGS; PREPARATION AND PROPERTIES; RELEASE RATE; SETTING TIME; SUSTAINED RELEASE;

BONE; CALCIUM; CALCIUM PHOSPHATE; CEMENTS; COMPRESSIVE STRENGTH; CONTROLLED DRUG DELIVERY; DEGRADATION; DRIERS (MATERIALS); DRUG PRODUCTS; MICROSPHERES; SETTING; SULFUR COMPOUNDS; TRANSMISSION CONTROL PROTOCOL;

BONE CEMENT;

BONE CEMENT; CALCIUM PHOSPHATE; CALCIUM SULFATE; CALCIUM SULFATE DIHYDRATE; GELATIN; GENTAMICIN; MICROSPHERE; UNCLASSIFIED DRUG;

ARTICLE; CANCELLOUS BONE; CONTROLLED STUDY; DEGRADATION; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; POROSITY; PRIORITY JOURNAL; STRENGTH; SUSTAINED DRUG RELEASE;

BIOCOMPATIBLE MATERIALS; BODY FLUIDS; BONE CEMENTS; CALCIUM PHOSPHATES; CALCIUM SULFATE; COMPRESSIVE STRENGTH; DRUG DELIVERY SYSTEMS; GELATIN; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSPHERES; TIME FACTORS;

EID: 84355161734     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-011-4432-2     Document Type: Article

References (40)

1. R LeGeros A Chohayeb A Shulman 1982 Apatitic calcium phosphates: possible dental restorative materials J Dent Res 61 343 348
2. W Brown L Chow 1983 A new calcium phosphate setting cement J Dent Res 62 672 678
3. RM Urban TM Turner DJ Hall N Inoue S Gitelis 2007 Increased bone formation using calcium sulfate-calcium phosphate composite graft Clin Orthop Relat Res 459 110 117 10.1097/BLO.0b013e318059b902 (Pubitemid 46878202)
4. EM Ooms JG Wolke JP van der Waerden JA Jansen 2002 Trabecular bone response to injectable calcium phosphate (Ca-P) cement J Biomed Mater Res 61 9 18 10.1002/jbm.10029 1:CAS:528:DC%2BD38XktlGgt74%3D (Pubitemid 34650250)
5. MR Sarkar N Wachter P Patka L Kinzl 2001 First histological observations on the incorporation of a novel calcium phosphate bone substitute material in human cancellous bone J Biomed Mater Res 58 329 334 10.1002/1097-4636(2001)58: 3<329::AID-JBM1025>3.0.CO;2-9 1:CAS:528:DC%2BD3MXjslCqs74%3D (Pubitemid 34274510)
6. RZ LeGeros JR Parsons G Daculsi F Driessens D Lee ST Liu S Metsger D Peterson M Walker 1988 Significance of the porosity and physical chemistry of calcium phosphate ceramics. Biodegradation-bioresorption Ann NY Acad Sci 523 268 274 10.1111/j.1749-6632.1988.tb38519.x 1:STN:280:DyaL1c3ltVyisw%3D%3D
7. LC Chow 2001 Calcium phosphate cements Monogr Oral Sci 18 148 163 10.1159/000061653 1:STN:280:DC%2BD38%2FjtFyisA%3D%3D
8. MF Basle D Chappard F Grizon R Filmon J Delecrin G Daculsi A Rebel 1993 Osteoclastic resorption of Ca-P biomaterials implanted in rabbit bone Calcif Tissue Int 53 348 356 10.1007/BF01351842 1:CAS:528:DyaK2cXitVSgtLg%3D (Pubitemid 23298420)
9. V Karageorgiou D Kaplan 2005 Porosity of 3D biomaterial scaffolds and osteogenesis Biomaterials 26 5474 5491 10.1016/j.biomaterials.2005.02.002 1:CAS:528:DC%2BD2MXjs1Wnsrc%3D (Pubitemid 40592136)
10. HJ Chung TG Park 2007 Surface engineered and drug releasing prefabricated scaffolds for tissue engineering Adv Drug Deliv Rev 59 249 262 10.1016/j.addr.2007.03.015 1:CAS:528:DC%2BD2sXmtlShurw%3D (Pubitemid 46879969)
11. WJEM Habraken LT de Jonge JGC Wolke L Yubao AG Mikos JA Jansen 2008 Introduction of gelatin microspheres into an injectable calcium phosphate cement J Biomed Mater Res A 87A 3 643 655 10.1002/jbm.a.31703 1:CAS:528: DC%2BD1cXhtlOqtbvI
12. WJEM Habraken JGC Wolke AG Mikos JA Jansen 2009 Porcine gelatin microsphere/calcium phosphate cement composites: an in vitro degradation study J Biomed Mater Res B 91B 2 555 561 10.1002/jbm.b.31429 1:CAS:528: DC%2BD1MXht1agsL3P
13. M Li X Liu X Liu B Ge K Chen 2009 Creation of macroporous calcium phosphate cements as bone substitutes by using genipin-crosslinked gelatin microspheres J Mater Sci Mater Med 20 925 934 10.1007/s10856-008-3654-4 1:CAS:528:DC%2BD1MXit1Ohtbs%3D
14. CML Clokie H Moghadam MT Jaskson GK Sandor 2002 Closure of critical sized defects with allogenic and alloplastic bone substitutes J Craniofac Surg 13 111 121 10.1097/00001665-200201000-00026 (Pubitemid 34873957)
15. H Schliephake R Grubber M Dard R Wenz S Scholz 2004 Repair of calvarial defects in rats by prefabricated hydroxyapatite cement implants J Biomed Mater Res A 69 382 390 10.1002/jbm.a.20121 1:STN:280:DC%2BD2c3islymtg%3D%3D (Pubitemid 38668163)
16. DP Link J van den Dolder WJ Jurgens JG Wolke JA Jansen 2006 Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles Biomaterials 27 4941 4947 10.1016/j.biomaterials.2006.05.022 1:CAS:528:DC%2BD28XlvFaktr4%3D (Pubitemid 44172900)
17. WJEM Habraken JGC Wolke AG Mikos JA Jansen 2006 Injectable PLGA microsphere/calcium phosphate cements: physical properties and degradation characteristics J Biomater Sci Polym Ed 17 6 1057 1074 10.1163/ 156856206778366004 1:CAS:528:DC%2BD28Xht1ahsLjF (Pubitemid 44559975)
18. Z Fei Y Hu D Wu H Wu R Lu J Bai H Song 2008 Preparation and property of a novel bone graft composite consisting of rhBMP-2 loaded PLGA microspheres and calcium phosphate cement J Mater Sci Mater Med 19 1109 1116 10.1007/s10856-007- 3050-5 1:CAS:528:DC%2BD1cXis1Whur0%3D (Pubitemid 351337469)
19. C Durucan PW Brown 2002 Reactivity of α-tricalcium phosphate J Mater Sci 37 963 969 10.1023/A:1014347814241 1:CAS:528:DC%2BD38XivV2ntr4%3D (Pubitemid 34269079)
20. M Bohner 2004 New hydraulic cements based on a-tricalcium phosphate-calcium sulfate dihydrate mixtures Biomaterials 25 741 749 10.1016/S0142-9612(03)00573-8 1:CAS:528:DC%2BD3sXosFOrt7g%3D (Pubitemid 37357289)
21. F Enrique DV Maria MG Maria L Jose T Ricardo VC Juan B Marc 2005 Modulation of porosity in apatitic cements by the use of α-tricalcium phosphate-calcium sulphate dihydrate mixtures Biomaterials 26 3395 3404 10.1016/j.biomaterials.2004.09.023 (Pubitemid 40044724)
22. YJ Zai S Cai W Zhou XD Li 2010 Mechanical behavior of calcium phosphate based cement/gelatin microspheres composite scaffolds J Chin Ceram Soc 38 8 1568 1572
23. S Cai KD Yao YH Guan 2003 Effects of hydroxyapatite seeds on the hydration of α-calcium phosphate cement J Chin Ceram Soc 31 1 108 112 1:CAS:528:DC%2BD3sXpslShsA%3D%3D
24. HC Liang WH Chang KJ Lin HW Sung 2003 Genipin-crosslinked gelatin microspheres as a drug carrier for intramuscular administration: in vitro and in vivo studies J Biomed Mater Res A 65 271 282 10.1002/jbm.a.10476
25. HJ Wei HH Yang CH Chen WW Lin SC Chen PH Lai Y Chang HW Sung 2007 Gelatin microspheres encapsulated with a nonpeptide angiogenic agent, ginsenoside Rgl, for intramyocardial injection in a rat model with infarcted myocardium J Control Release 120 27 34 10.1016/j.jconrel.2007.04.005 1:CAS:528:DC%2BD2sXmt1Gls7c%3D (Pubitemid 46874622)
26. T Kokubo H Takadama 2006 How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27 2907 2915 10.1016/j.biomaterials.2006.01.017 1:CAS:528:DC%2BD28Xht1Crt7o%3D (Pubitemid 43208916)
27. HH Beherei GT El-Bassyouni KR Mohamed 2008 Modulation, characterization and bioactivity of new biocomposites based on apatite Ceram Int 34 2091 2097 10.1016/j.ceramint.2007.08.003 1:CAS:528:DC%2BD1cXhtF2nurzJ
28. X Zhang UP Wyss D Pichora MFA Goosen 1994 Biodegrable controlled antibiotic release devices for osteomyelitis-optimization of release properties J Pharm Pharmacol 46 718 724 10.1111/j.2042-7158.1994.tb03890.x 1:CAS:528:DyaK2cXms1entb0%3D (Pubitemid 24289659)
29. CP Frutos PE Díez JM Barrales-Rienda G Frutos 2000 Validation and in vitro characterization of antibiotic-loaded bone cement release Int J Pharm 209 15 26 10.1016/S0378-5173(00)00520-2
30. A Bigi B Bracci S Panzavolta 2004 Effect of added gelatin on the properties of calcium phosphate cement Biomaterials 25 2893 2899 10.1016/j.biomaterials.2003.09.059 1:CAS:528:DC%2BD2cXhtVenu7g%3D (Pubitemid 38201315)
31. MY Shie DC Chen CY Wang TY Chiang SJ Ding 2008 Immersion behavior of gelatin-containing calcium phosphate cement Acta Biomater 4 646 655 10.1016/j.actbio.2007.10.011 1:CAS:528:DC%2BD1cXhtVarsrrK (Pubitemid 351461282)
32. H Guo JC Su J Wei H Kong CS Liu 2009 Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering Acta Biomater 5 268 278 10.1016/j.actbio. 2008.07.018 1:CAS:528:DC%2BD1MXhsVamtLs%3D
33. 2+ and phosphate ions Dent Mater 25 261 268 10.1016/j.dental.2008.07.005
34. RP Del Real JGC Wolke M Vallet-Regi JA Jansen 2002 A new method to produce macropores in calcium phosphate cements Biomaterials 23 3673 3680 10.1016/S0142-9612(02)00101-1 1:CAS:528:DC%2BD38XksVShtrY%3D (Pubitemid 34626570)
35. HHK Xu CG Simon Jr 2004 Self-hardening calcium phosphate cement-mesh composite: reinforcement, macropores, and cell response J Biomed Mater Res A 69 267 278 10.1002/jbm.a.20124 (Pubitemid 38478819)
36. S Sánchez-Salcedo F Balas I Izquierdo-Barba M Vallet-Regí 2009 In vitro structural changes in porous HA/β-TCP scaffolds in simulated body fluid Acta Biomater 5 7 2738 2751 10.1016/j.actbio.2009.03.025
37. HHK Xu EF Burguera LE Carey 2007 Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures Biomaterials 28 3786 3796 10.1016/j.biomaterials.2007.05.015 1:CAS:528:DC%2BD2sXns1KmtLs%3D (Pubitemid 47048357)
38. J Wei JF Jia F Wu SH Wei J Zhou HB Zhang J Shin CS Liu 2010 Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration Biomaterials 31 1260 1269 10.1016/j.biomaterials. 2009.11.005 1:CAS:528:DC%2BD1MXhs1SltL3J
39. AL Doadrio EMB Sousa JC Doadrio JP Pariente II Barba M Vallet-Regi 2004 Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery J Control Release 97 125 132 10.1016/j.jconrel.2004.03.005 1:CAS:528: DC%2BD2cXjvFOntLw%3D (Pubitemid 38624515)
40. WN Liu J Chang 2009 In vitro evaluation of gentamicin release from a bioactive tricalcium silicate bone cement Mater Sci Eng C 29 2486 2492 10.1016/j.msec.2009.07.015 1:CAS:528:DC%2BD1MXht1Ggu7rO