Preparation of celecoxib solid dispersions for dermal application: In vitro characterization and skin irritation test

Journal of Drug Delivery Science and Technology

Volumn 21, Issue 6, 2011, Pages 509-516

  Soliman, S M ^a   Abdel Malak, N S ^b   El Gazayerly, O N ^b   Abdel Rehim, A A ^a  

^a 6 October Governorate   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Anti inflammatory effect; Celecoxib; Histopathology; Skin permeation; Solid dispersions

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CELECOXIB; MACROGOL 4000; POVIDONE; WATER OIL CREAM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG PENETRATION; DRUG SAFETY; DRUG SOLUBILITY; HISTOPATHOLOGY; IN VITRO STUDY; MALE; NONHUMAN; PAW EDEMA; RAT; SKIN IRRITATION; SKIN PERMEABILITY;

EID: 84255183160     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(11)50082-6     Document Type: Article

References (47)

1. Subramanian N., Ray S., Ghosal S.K., Bhadra R., Moulik S.P. - Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. - Biol. Pharm. Bull., 12, 1993-1999, 2004. (Pubitemid 41701577)
2. Hersh E.V., Lally E.T., Moore P.A. - Update on cyclooxygenase inhibitors: has a third isoform entered the fray. - Curr. Med. Res. Opin., 21, 1217-1226, 2005. (Pubitemid 41140725)
3. Kogan A., Garti N. - Microemulsions as transdermal drug delivery vehicles. - Adv. Colloids Interface Sci., 369, 123-126, 2006.
4. Ford J.L. - The effect of particle size on some in vitro and in vivo properties of indomethacin-polyethylene glycol 6000 solid dispersion. - Drug Dev. Ind. Pharm., 12, 1777-1793, 1986.
5. Tanabe K., Itoh S., Iwasaki T., Nakano Y., Yamazaki M. - Rectal absorption enhancement of oxaprozin using solid dispersions with polyvinylpyrrolidone. - Jpn. J. Hosp. Pharm., 6, 509-514, 1994.
6. Kearney A.S., Gabriel D.L., Mehta S.C., Radebaugh G.W. - Effect of polyvinylpyrrolidone on the crystallinity and dissolution rate of solid dispersions of the antiinflammatory CI-987. - Int. J. Pharm., 2, 169-174, 1994. (Pubitemid 24073701)
7. Craig D.Q.M. - The mechanisms of drug release from solid dispersions in water-soluble polymers. - Int. J. Pharm., 231, 131-144, 2002 (Pubitemid 34033673)
8. Chiou W.L., Riegelman S. - Pharmaceutical applications of solid dispersion systems. - J. Pharm. Sci., 9, 1281-1302, 1971.
9. Shakeel F., Baboota S., Ahuja A., Ali J., Shafiq S. - Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion. - J. Nanobiotech., 6, 8-20, 2008.
10. Soliman S.M., Abdel Malak N.S., El-Gazayerly O.N., Abdel Rehim A.A. - Formulation of microemulsion gel systems for transdermal delivery of celecoxib: in vitro permeation, anti-inflammatory activity and skin irritation test. - DDT, 4, 459-471, 2010.
11. Saleem M.A., Bala S. - Formulation and evaluation of meloxicam solid dispersion incorporated topical gels. - Int. J. Pharm. Bio. Sci., 1, 3, 2010.
12. Desai K.G.H. - Enhanced skin permeation of rofecoxib using topical microemulsion gel. - Drug Dev. Res., 63, 33-40, 2004. (Pubitemid 40076276)
13. Ventura C.A., Tommasini S., Falcone A., Giannone I., Paolino D., Sdrafkakis V., Mondello M.R., Puglisi G. - Influence of modified cyclodextrins on solubility and percutaneous absorption of celecoxib through human skin. - Int. J. Pharm., 314, 37-45, 2006.
14. Nagarsenker M.S, Joshi M.S. - Celecoxib-cyclodextrin systems: characterization and evaluation of in vitro and in vivo advantage. - Drug Dev. Ind. Pharm., 31, 169-178, 2005. (Pubitemid 40315712)
15. Tashtoush B.M., Al-Qashi Z.S., Najib N.M. - In vitro and in vivo evaluation of glibenclamide in solid dispersion systems. - Drug Dev. Ind. Pharm., 6, 601-607, 2004. (Pubitemid 38924630)
16. Abdelkader H., Abdalla O.Y, Salem H. - Formulation of controlled-release baclofen matrix tablets: influence of some hydrophilic polymers on the release rate and in vitro evaluation. - AAPS Pharm. Sci. Tech., 4, 156-166, 2007.
17. Subramanian N., Ghosal S.K., Moulik S.P. - Enhanced in vitro percutaneous absorption and in vivo anti-inflammatory effect of a selective cyclooxygenase inhibitor using microemulsion. - Drug Dev. Ind. Pharm., 31, 405-416, 2005. (Pubitemid 41289153)
18. Kantarci G., Ozgungey I., Karasulu H.Y., Guneri T., Basdemir G. - In vitro permeation of diclofenac sodium from novel microemulsion formulations through rabbit skin. - Drug Dev. Res., 65, 17-25, 2005. (Pubitemid 41462892)
19. Wissing S.A., Muller R.H. - Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration. - J. Control. Rel., 81, 225-233, 2002. (Pubitemid 34607144)
20. Jain S.K., Gupta Y., Jain A., Bhola M. - Multivesicular liposomes bearing celecoxib-β-cyclodextrin complex for transdermal delivery. - Drug Del., 14, 327-335, 2007. (Pubitemid 47265818)
21. Osborne D.W., Ward A.J., O'Neill K.J. - Microemulsions as topical drug delivery vehicles: in-vitro transdermal studies of a model hydrophilic drug. - J. Pharm. Pharmacol. Comm., 43, 451-454, 1991.
22. Trotta M., Pattarino F., Gasco M.R. - Influence of counter ions on the skin permeation of methotrexate from water-oil microemulsions. - Pharm. Acta Helv., 71, 135-140, 1996. (Pubitemid 26281323)
23. Winter C.A., Risley E.A, Nuss G.W. - Carrageenan induced edema in hind paws of the rats as an assay for anti-inflammatory drugs. - Proc. Soc. Exp. Biol. Med., 111, 544-547, 1962.
24. Winter C.A. - Anti-inflammatory testing methods: comparative evaluation of indomethacin and other agents. - Int. Symp. NSAID, 82, 190-202, 1965.
25. Dhavan B.N. - Organization of biological screening program for natural products. Use of pharmacological techniques for the study of natural products. - Proc. UNESCO-CDRI Workshop, Central Drug Research Institute, Lukhnow, 1992, p. 3-29.
26. Vinegar R., Schreiber W., Hugo R. - Biphasic development of carrageenan edema in rats. - J. Pharmacol. Exp. Ther., 166, 96-103, 1969.
27. Draize J., Woodward G., Calvery H. - Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. - J. Pharmacol. Exp. Ther., 82, 377-379, 1944.
28. Kaur K., Jain S., Sapra B., Tiwary A.K. - Niosomal gel for site-specific sustained delivery of anti-arthritic drug: in vitro-in vivo evaluation. - Curr. Drug Del., 4, 276-282, 2007. (Pubitemid 47549496)
29. Gupta P., Kakumanu V., Bansal A. - Stability and solubility of Celecoxib-PVP amorphous dispersions: a molecular perspective. - Pharm. Res., 21, 1762-1769, 2004. (Pubitemid 39390086)
30. Punitha S., Karthikeyan D., Devi P., Vedha Hari B.N. - Enhancement of solubility and dissolution of celecoxib by solid dispersion technique. - JPST, 1, 63-68, 2009.
31. Dixit R.P., Nagersenker M.S. - In vitro and in vivo advantages of celecoxib surface solid dispersion and dosage form development. - Int. J. Pharm. Sci., 69, 370-377, 2007.
32. El-Badry M., Fathy M. - Enhancement of the dissolution and permeation rates of meloxicam by formation of its freeze-dried solid dispersions in polyvinylpyrrolidone K30. - J. Drug Dev. Ind. Pharm., 32, 141-150, 2006.
33. Chokshi R.J., Zia H, Sandhu H.K., Shah N.H., Malick W.A. - Improving the dissolution rate of poorly water soluble drug by solid dispersion and solid solution, Pros and Cons. - Drug Del.,14, 33-45, 2007. (Pubitemid 44764457)
34. Kumar N., Jain A.K., Singh C., Kumar R. - Development, characterization and solubility study of solid dispersion of terbinafine hydrochloride by solvent evaporation method. - Asian J. Pharm., 2, 154-158, 2008.
35. Chiou W.L., Riegelman S. - Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin. - J. Pharm. Sci., 58, 1505-1510, 1969
36. Sekikawa H., Fujiwara J., Naganuma T., Nakano M., Arita T. - Dissolution behaviors and gastrointestinal absorption of phenytoin in phenytoin- polyvinylpyrrolidone coprecipitate. - Chem. Pharm. Bull., 26, 3033-3039, 1987.
37. Ulla M.R., Gangadharappa H.V., Rathod N. - Solubility and dissolution improvement of rofecoxib using solid dispesion technique. - Pak. J. Pharm. Sci., 4, 350-355, 2008.
38. Ahsan F., Viega M.D. - Study of tolbutamide-hydroxypropyl-Bcyclodextrin interaction in solution and solid state. - Chem. Pharm. Bull., 48, 793-797, 2000. (Pubitemid 30430114)
39. Ventura C.A., Giannone I., Paolino D., Pistare V., Corsaro A., Puglisi G. - Preparation of celecoxib-dimethyl-β-cyclodextrin inclusion complex:characterization and in vitro permeation study. - Eur. J. Med. Chem., 40, 624-631, 2005. (Pubitemid 40797558)
40. Veiga M.D., Diaz P.J., Ahsan F. - Interactions of griseofulvin with cyclodextrins in solid binary systems. - J. Pharm. Sci., 87, 891-900,1998. (Pubitemid 28319422)
41. Sinha V.R., Anitha R., Ghosh S., Nanda A., Kumria R. - Complexation of celecoxib with β-cyclodextrin: characterization of the interaction in solution and in solid state. - J. Pharm. Sci., 94, 676-687, 2005. (Pubitemid 40476531)
42. Fernandes C.M., Vieira M.T., Veiga F.J.B. - Physicochemical characterization and in vitro dissolution behaviour of nicardipine-cyclodextrin inclusion compounds. - Eur. J. Pharm. Sci., 15, 79-88, 2002. (Pubitemid 34136971)
43. Saleem M.A., Kumar S.V., Khalid S., Sudhir P., Omair A. - Study on in vitro permeation enhancement of ketoprofen by formation of solid dispersion. - IRJP, 2, 134-140, 2011.
44. Muralidhar S., Rao G.D., Nizami S.A., Reddy K., Reddy S.R. Enhancement of dissolution rate and anti-inflammatory potential of celecoxib using solid dispersion technique. - J. Adv. Pharm. Res., 1, 74-81, 2010.
45. st ed., 2005, p. 127.
46. Mittal A., Sara U.S., Ali A., Mohammad A. - Design, development, physicochemical, in vitro and in vivo evaluation of monolithic matrix type transdermal patches containing nitrendipine. - Pharm. Dev. Technol., 14, 422-434, 2009.
47. Nair B. - Final report on the safety sssessment of polyvinylpyrrolidone (PVP). - Int. J.Tox., 17, 95-130, 1998.