Genome-wide microarray analysis of human fibroblasts in response to γ radiation and the radiation-induced bystander effect

Radiation Research

Volumn 177, Issue 1, 2012, Pages 35-43

  Kalanxhi, Erta ^a   Dahle, Jostein ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER RADIOTHERAPY; CELLULAR IMMUNITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FIBROBLAST; GAMMA RADIATION; GENE CONTROL; GENE INDUCTION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RADIATION EXPOSURE; RIBOSOME; SIGNAL TRANSDUCTION;

BYSTANDER EFFECT; CELL CYCLE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; GAMMA RAYS; GENOMICS; HUMANS; MICRONUCLEUS TESTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATION-REDUCTION; PHOSPHORYLATION; REPRODUCIBILITY OF RESULTS; RIBOSOMES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

EID: 84255172290     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2694.1     Document Type: Article

References (47)

1. Prise KM, O'Sullivan JM. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer 2009; 9:351-60.
2. Mothersill C, Seymour C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int J Radiat Biol 1997; 71:421-7. (Pubitemid 27187398)
3. Belyakov OV, Folkard M, Mothersill C, Prise KM, Michael BD. A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation. Br J Cancer 2003; 88:767-74. (Pubitemid 36411458)
4. Belyakov OV, Folkard M, Mothersill C, Prise KM, Michael BD. Bystander-induced differentiation: a major response to targeted irradiation of a urothelial explant model. Mutat Res 2006; 597:43-9.
5. Hall EJ and Hei TK. Genomic instability and bystander effects induced by high LET radiation. Oncogene 2003; 22:7034-42. (Pubitemid 37386672)
6. Sawant SG, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ. The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat Res 2001; 155:397-401. (Pubitemid 32204255)
7. Mothersill C, Seymour CB. Radiation-induced bystander effects- implications for cancer. Nat Rev Cancer 2004; 4:158-64. (Pubitemid 38198744)
8. Nagasawa H, Little JB. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res 1992; 52:6394-6.
9. Dahle J, Kvam E. Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation. Cancer Res 2003; 63:1464-9. (Pubitemid 36373630)
10. Dahle J, Kaalhus O, Moan J, Steen HB. Cooperative effects of photodynamic treatment of cells in microcolonies. Proc Natl Acad Sci U S A 1997; 94:1773-8. (Pubitemid 27113911)
11. Dahle J, Mikalsen SO, Rivedal E, Steen HB. Gap junctional intercellular communication is not a major mediator in the bystander effect in photodynamic treatment of MDCK II cells. Radiat Res 2000; 154:331-41.
12. Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc Natl Acad Sci U S A 2001; 98:473-8. (Pubitemid 32105066)
13. Shao C, Folkard M, Prise KM. Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene 2008; 27:434-40.
14. Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, et al. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci U S A 2005; 102:14641-6. (Pubitemid 41457109)
15. Lyng FM, Maguire P, McClean B, Seymour C, Mothersill C. The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiat Res 2006; 165:400-9.
16. Seymour C, Mothersill C. Cell communication and the "bystander effect". Radiat Res 1999; 151:505-6.
17. Mothersill C, Seymour C. Radiation-induced bystander and other non-targeted effects: novel intervention points in cancer therapy? Curr Cancer Drug Targets 2006 6 447-54 (Pubitemid 44033392)
18. Buonanno M, de Toledo SM, Pain D, Azzam EI. Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress. Radiat Res 2011; 175:405-15.
19. Mothersill CE, Moriarty MJ, Seymour CB. Radiotherapy and the potential exploitation of bystander effects. Int J Radiat Oncol Biol Phys 2004; 58:575-9. (Pubitemid 38142486)
20. Butterworth KT, McGarry CK, Trainor C, O'Sullivan JM, Hounsell AR, Prise KM. Out-of-field cell survival following exposure to intensity-modulated radiation fields. Int J Radiat Oncol Biol Phys 2011; 79:1516-22.
21. Bentzen SM. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer 2006; 6:702-13. (Pubitemid 44286002)
22. Morgan WF. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat Res 2003; 159:567-80.
23. Kis E, Szatmari T, Keszei M, Farkas R, Esik O, Lumniczky K, et al. Microarray analysis of radiation response genes in primary human fibroblasts. Int J Radiat Oncol Biol Phys 2006; 66:1506-14.
24. Ouellette MM, McDaniel LD, Wright WE, Shay JW, Schultz RA. The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum Mol Genet 2000; 9:403-11. (Pubitemid 30098734)
25. Fenech M. Cytokinesis-block micronucleus cytome assay. Nat Protoc 2007; 2:1084-1104. (Pubitemid 46901289)
26. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30:207-10. (Pubitemid 34679544)
27. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001; 98:5116-21. (Pubitemid 32397092)
28. Thomas PD, Campbell MJ, Kejariwal A, Mi H, Karlak B, Daverman R, et al. PANTHER: a library of protein families and subfamilies indexed by function. Genome Res 2003; 13:2129-41. (Pubitemid 37161770)
29. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005; 102:15545-50. (Pubitemid 41528093)
30. Andersson FI, Werrell EF, McMorran L, Crone WJK, Das C, Hsu STD, et al. The effect of Parkinson's-disease-associated mutations on the deubiquitinating enzyme UCH-L1. J Mol Biol 2011; 407:261-72.
31. Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, et al. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A 2004; 101:1075-80. (Pubitemid 38160586)
32. Daniels DJ, Clothier C, Swan DC, Saretzki G. Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts. Biochem Biophys Res Commun 2010; 399:7-13.
33. Markowska AI, Liu FT, Panjwani N. Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med 2010; 207:1981-93.
34. Chen S, Zhao Y, Han W, Zhao G, Zhu L, Wang J, et al. Mitochondria- dependent signalling pathway are involved in the early process of radiation-induced bystander effects. Br J Cancer 2008; 98:1839-44. (Pubitemid 351748834)
35. Maguire P, Mothersill C, Seymour C, Lyng FM. Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. Radiat Res 2005; 163:384-90. (Pubitemid 40404646)
36. Pandey BN, Gordon DM, de Toledo SM, Pain D, Azzam EI. Normal human fibroblasts exposed to high- or low-dose ionizing radiation: differential effects on mitochondrial protein import and membrane potential. Antioxid Redox Signal 2006; 8:1253-61. (Pubitemid 44182424)
37. Zhou H, Ivanov VN, Lien YC, Davidson M, Hei TK. Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res 2008; 68:2233-40. (Pubitemid 351521796)
38. Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, et al. Large-scale chemical dissection of mitochondrial function. Nat Biotech 2008; 26:343-51. (Pubitemid 351355127)
39. Tsai ML, Chang KY, Chiang CS, Shu WY, Weng TC, Chen CR, et al. UVB radiation induces persistent activation of ribosome and oxidative phosphorylation pathways. Radiat Res 2009; 171:716-24.
40. Ghandhi SA, Yaghoubian B, Amundson SA Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: synchronous and differential responses. BMC Med Genomics 2008; 1:63
41. Ghandhi S, Ming L, Ivanov V, Hei T, Amundson S. Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts. BMC Med Genomics 2010; 3:31.
42. Mezentsev A, Amundson SA. Global gene expression responses to low- or high-dose radiation in a human three-dimensional tissue model. Radiat Res 2011; 175:677-88.
43. Rodningen OK, Overgaard J, Alsner J, Hastie T, Borresen-Dale AL. Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts. Radiother Oncol 2005; 77:231-240. (Pubitemid 41785330)
44. Kabacik S, Mackay A, Tamber N, Manning G, Finnon P, Paillier F, et al. Gene expression following ionising radiation: Identification of biomarkers for dose estimation and prediction of individual response. Int J Radiat Biol 2010; 87:115-29.
45. Rzeszowska-Wolny J, Herok R, Widel M, Hancock R. Xirradiation and bystander effects induce similar changes of transcript profiles in most functional pathways in human melanoma cells. DNA Repair (Amst) 2009; 8:732-8.
46. Herok R, Konopacka M, Polanska J, Swierniak A, Rogolinski J, Jaksik R, et al. Bystander effects induced by medium from irradiated cells: similar transcriptome responses in irradiated and bystander K562 cells. Int J Radiat Oncol Biol Phys 2010; 77:244-52.
47. Gorman S, Fox E, O'Donoghue D, Sheahan K, Hyland J, Mulcahy H, et al. Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects. J Mol Med 2010; 88:701-8.