An intravenous insulin protocol for strict glycemic control in acute ischaemic stroke

European Journal of Neurology

Volumn 19, Issue 3, 2012, Pages 443-451

  Ntaios, G ^a   Egli, M ^a   Arsovska, A ^a   Joye, D ^a   Bettex, Y ^a   Lauber, E ^a   Eskandari, A ^a   D'Ambrogio, S ^a   Richoz, B ^a   Ruiz, J ^a   Michel, P ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Intravenous insulin; Ischaemic stroke; Post stroke hyperglycemia

Indexed keywords

GLUCOSE; INSULIN; NEUTRAL INSULIN; POTASSIUM;

ACUTE HEART FAILURE; AGED; ARTICLE; BLOOD GLUCOSE MONITORING; BRAIN ISCHEMIA; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART ATRIUM FIBRILLATION; HUMAN; HYPOKALEMIA; KIDNEY FAILURE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STROKE PATIENT; STROKE UNIT; SUPRAVENTRICULAR TACHYCARDIA; TREATMENT DURATION;

AGED; AGED, 80 AND OVER; ALGORITHMS; BLOOD GLUCOSE; DIABETES MELLITUS; FEMALE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; HYPOKALEMIA; INFUSIONS, INTRAVENOUS; INSULIN; MALE; RETROSPECTIVE STUDIES; STROKE;

EID: 84155172953     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2011.03537.x     Document Type: Article

References (27)

1. Quinn TJ, Lees KR. Hyperglycaemia in acute stroke-to treat or not to treat. Cerebrovasc Dis 2009; 27(Suppl. 1): 148-155.
2. Allport L, Baird T, Butcher K, et al. Frequency and temporal profile of poststroke hyperglycemia using continuous glucose monitoring. Diabetes Care 2006; 29: 1839-1844.
3. Ntaios G, Egli M, Faouzi M, Michel P. J-shaped association between serum glucose and functional outcome in acute ischemic stroke. Stroke 2010; 41: 2366-2370.
4. Kruyt ND, Biessels GJ, DeVries JH, Roos YB. Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management. Nat Rev Neurol 2010; 6: 145-155.
5. Frontera JA. Intensive versus conventional insulin therapy in critically ill neurologic patients: still searching for the sweet spot. Neurocrit Care 2010; 13: 295-298.
6. Godoy DA, Di NM, Rabinstein AA. Treating hyperglycemia in neurocritical patients: benefits and perils. Neurocrit Care 2010; 13: 425-438.
7. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001; 32: 2426-2432.
8. Walters MR, Weir CJ, Lees KR. A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients. Cerebrovasc Dis 2006; 22: 116-122.
9. Graffagnino C, Gurram AR, Kolls B, Olson DM. Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes. Neurocrit Care 2010; 13: 307-312.
10. Green DM, O'Phelan KH, Bassin SL, Chang CW, Stern TS, Asai SM. Intensive versus conventional insulin therapy in critically ill neurologic patients. Neurocrit Care 2010; 13: 299-306.
11. Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360: 1283-1297.
12. Bruno A, Kent TA, Coull BM, et al. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke 2008; 39: 384-389.
13. McCormick M, Hadley D, McLean JR, Macfarlane JA, Condon B, Muir KW. Randomized, controlled trial of insulin for acute poststroke hyperglycemia. Ann Neurol 2010; 67: 570-578.
14. The European Stroke Organisation (ESO) Executive Committee and the ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008; 25: 457-507.
15. Adams HP, Jr, del ZG, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007; 38: 1655-1711.
16. Markovitz LJ, Wiechmann RJ, Harris N, et al. Description and evaluation of a glycemic management protocol for patients with diabetes undergoing heart surgery. Endocr Pract 2002; 8: 10-18.
17. Michel P, Odier C, Rutgers M, et al. The Acute STroke Registry and Analysis of Lausanne (ASTRAL): design and baseline analysis of an ischemic stroke registry including acute multimodal imaging. Stroke 2010; 41: 2491-2498.
18. Woo J, Lam CW, Kay R, Wong AH, Teoh R, Nicholls MG. The influence of hyperglycemia and diabetes mellitus on immediate and 3-month morbidity and mortality after acute stroke. Arch Neurol 1990; 47: 1174-1177.
19. De Silva DA, Ebinger M, Christensen S, et al. Baseline diabetic status and admission blood glucose were poor prognostic factors in the EPITHET trial. Cerebrovasc Dis 2010; 29: 14-21.
20. Staszewski J, Brodacki B, Kotowicz J, Stepien A. Intravenous insulin therapy in the maintenance of strict glycemic control in nondiabetic acute stroke patients with mild hyperglycemia. J Stroke Cerebrovasc Dis 2011; 20: 150-154.
21. Kreisel SH, Berschin UM, Hammes HP, et al. Pragmatic management of hyperglycaemia in acute ischaemic stroke: safety and feasibility of intensive intravenous insulin treatment. Cerebrovasc Dis 2009; 27: 167-175.
22. Bruno A, Saha C, Williams LS, Shankar R. IV insulin during acute cerebral infarction in diabetic patients. Neurology 2004; 62: 1441-1442.
23. Kruyt ND, Biessels GJ, Vriesendorp TM, et al. Subjecting acute ischemic stroke patients to continuous tube feeding and an intensive computerized protocol establishes tight glycemic control. Neurocrit Care 2010; 12: 62-68.
24. Vriesendorp TM, Roos YB, Kruyt ND, et al. Efficacy and safety of two 5day insulin dosing regimens to achieve strict glycaemic control in patients with acute ischaemic stroke. J Neurol Neurosurg Psychiatry 2009; 80: 1040-1043.
25. Gray CS, Hildreth AJ, Sandercock PA, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol 2007; 6: 397-406.
26. Johnston KC, Hall CE, Kissela BM, Bleck TP, Conaway MR. Glucose Regulation in Acute Stroke Patients (GRASP) trial: a randomized pilot trial. Stroke 2009; 40: 3804-3809.
27. Diaz R, Goyal A, Mehta SR, et al. Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction. JAMA 2007; 298: 2399-2405.