Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1-7)-mas axis

Toxicology

Volumn 291, Issue 1-3, 2012, Pages 139-145

  Arumugam, Somasundaram ^a   Thandavarayan, Rajarajan A ^a   Palaniyandi, Suresh S ^b   Giridharan, Vijayasree V ^a   Arozal, Wawaimuli ^a   Sari, Flori R ^a   Soetikno, Vivian ^a   Harima, Meilei ^a   Suzuki, Kenji ^c   Kodama, Makoto ^c   Watanabe, Kenichi ^a  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Ang (1 7); Candesartan cilexetil; Cardioprotection; Heart failure; Mas

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN RECEPTOR; CANDESARTAN HEXETIL; CARDIAC MYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CARDIOTOXICITY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE COURSE; ENDOPLASMIC RETICULUM STRESS; HISTOPATHOLOGY; IMMUNIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; WESTERN BLOTTING;

ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOIMMUNE DISEASES; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; HEART DISEASES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MYOCARDITIS; MYOSINS; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; PROTO-ONCOGENE PROTEINS; RATS; RATS, INBRED LEW; RECEPTORS, G-PROTEIN-COUPLED; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; TETRAZOLES;

RATTUS; SUS;

EID: 84155171097     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.11.008     Document Type: Article

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