Intranasal immunization of the combined Lipooligosaccharide conjugates protects mice from the challenges with three serotypes of Moraxella catarrhalis

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Ren, Dabin ^a,d   Xie, Hang ^b   Zhang, Wenhong ^a   Hassan, Ferdaus ^a,e   Petralia, Ronald S ^a   Yu, Shengqing ^a,f   Lim, David J ^c   Gu, Xin Xing ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c HOUSE EAR INSTITUTE   (United States)

^d MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^f INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; CHOLERA TOXIN; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 12; INTERLEUKIN 4; LIPOOLIGOSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; BACTERIUM ANTIBODY; LIPID LINKED OLIGOSACCHARIDES; LIPID-LINKED OLIGOSACCHARIDES; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL STRAIN; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; IMMUNIZATION; LUNG STRUCTURE; MORAXELLA CATARRHALIS; MORAXELLACEAE INFECTION; MOUSE; NONHUMAN; PNEUMONIA; SEROTYPE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CARBOHYDRATE ANALYSIS; CHEMISTRY; IMMUNOELECTRON MICROSCOPY; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; LUNG; METABOLISM; MOLECULAR GENETICS; MUCOSAL IMMUNITY; ULTRASTRUCTURE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; CARBOHYDRATE SEQUENCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNITY, MUCOSAL; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, INBRED BALB C; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; MORAXELLA (BRANHAMELLA) CATARRHALIS; MORAXELLACEAE INFECTIONS;

EID: 84055216985     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029553     Document Type: Article

References (30)

1. Murphy TF, Parameswaran GI, (2009) Moraxella catarrhalis, a human respiratory tract pathogen. Clin Infect Dis 49: 124-131.
2. Murphy TF, Brauer AL, Grant BJ, Sethi S, (2005) Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response. Am J Respir Crit Care Med 172: 195-199.
3. Klein JO, (1994) Otitis media. Clin Infect Dis 19: 823-833.
4. American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media (2004) Diagnosis and management of acute otitis media. Pediatrics 113: 1451-1465.
5. McMichael JC, (2000) Vaccines for Moraxella catarrhalis. Vaccine 19 (Suppl 1): S101-107.
6. Tan TT, Riesbeck K, (2007) Current progress of adhesins as vaccine candidates for Moraxella catarrhalis. Expert Rev Vaccines 6: 949-956.
7. Mawas F, Ho MM, Corbel MJ, (2009) Current progress with Moraxella catarrhalis antigens as vaccine candidates. Expert Rev Vaccines 8: 77-90.
8. Tan TT, Christensen JJ, Dziegiel MH, Forsgren A, Riesbeck K, (2006) Comparison of the serological responses to Moraxella catarrhalis immunoglobulin D-binding outer membrane protein and the ubiquitous surface proteins A1 and A2. Infect Immun 74: 6377-6386.
9. Chen D, McMichael JC, VanDerMeid KR, Hahn D, Mininni T, et al. (1996) Evaluation of purified UspA from Moraxella catarrhalis as a vaccine in a murine model after active immunization. Infect Immun 64: 1900-1905.
10. Aebi C, Cope LD, Latimer JL, Thomas SE, Slaughter CA, et al. (1998) Mapping of a protective epitope of the CopB outer membrane protein of Moraxella catarrhalis. Infect Immun 66: 540-548.
11. Xie H, Gu XX, (2008) Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naive monocytes to produce TNF-alpha through cellular cross-talk. Cell Microbiol 10: 1453-1467.
12. Vaneechoutte M, Verschraegen G, Claeys G, Van Den Abeele AM, (1990) Serological typing of Branhamella catarrhalis strains on the basis of lipopolysaccharide antigens. J Clin Microbiol 28: 182-187.
13. Rahman M, Jonsson AB, Holme T, (1998) Monoclonal antibodies to the epitope alpha-Gal-(1-4)-beta-Gal-(1- of Moraxella catarrhalis LPS react with a similar epitope in type IV pili of Neisseria meningitidis. Microb Pathog 24: 299-308.
14. Edebrink P, Jansson PE, Rahman MM, Widmalm G, Holme T, et al. (1994) Structural studies of the O-polysaccharide from the lipopolysaccharide of Moraxella (Branhamella) catarrhalis serotype A (strain ATCC 25238). Carbohydr Res 257: 269-284.
15. Edebrink P, Jansson PE, Widmalm G, Holme T, Rahman M, (1996) The structures of oligosaccharides isolated from the lipopolysaccharide of Moraxella catarrhalis serotype B, strain CCUG 3292. Carbohydr Res 295: 127-146.
16. Edebrink P, Jansson PE, Rahman MM, Widmalm G, Holme T, et al. (1995) Structural studies of the O-antigen oligosaccharides from two strains of Moraxella catarrhalis serotype C. Carbohydr Res 266: 237-261.
17. Gu XX, Chen J, Barenkamp SJ, Robbins JB, Tsai CM, et al. (1998) Synthesis and characterization of lipooligosaccharide-based conjugates as vaccine candidates for Moraxella (Branhamella) catarrhalis. Infect Immun 66: 1891-1897.
18. Yu S, Gu XX, (2005) Synthesis and characterization of lipooligosaccharide-based conjugate vaccines for serotype B Moraxella catarrhalis. Infect Immun 73: 2790-2796.
19. Yu S, Gu XX, (2007) Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis. Infect Immun 75: 2974-2980.
20. Jiao X, Hirano T, Hou Y, Gu XX, (2002) Specific immune responses and enhancement of murine pulmonary clearance of Moraxella catarrhalis by intranasal immunization with a detoxified lipooligosaccharide conjugate vaccine. Infect Immun 70: 5982-5989.
21. Hu WG, Chen J, Battey JF, Gu XX, (2000) Enhancement of clearance of bacteria from murine lungs by immunization with detoxified lipooligosaccharide from Moraxella catarrhalis conjugated to proteins. Infect Immun 68: 4980-4985.
22. Hu WG, Chen J, Collins FM, Gu XX, (1999) An aerosol challenge mouse model for Moraxella catarrhalis. Vaccine 18: 799-804.
23. McMichael JC, (2000) Progress toward the development of a vaccine to prevent Moraxella (Branhamella) catarrhalis infections. Microbes Infect 2: 561-568.
24. Brandtzaeg P, (2003) Role of secretory antibodies in the defence against infections. Int J Med Microbiol 293: 3-15.
25. Lee CJ, Lee LH, Gu XX, (2005) Mucosal immunity induced by pneumococcal glycoconjugate. Crit Rev Microbiol 31: 137-144.
26. Goldblum RM, Hanson LÅ, Brandtzaeg P, (1996) The mucosal defense system. In: Stiehm ER, editors. Immunologic Disorders in Infants and Children 4th ed. Philadelphia, PA W. B. Saunders Co pp. 159-199.
27. Murphy S, Florman AL, (1983) Lung defenses against infection: a clinical correlation. Pediatrics 72: 1-15.
28. Welsh DA, Mason CM, (2001) Host defense in respiratory infections. Med Clin North Am 85: 1329-1347.
29. McGhee JR, Czerkinsky C, Mesteckey J, (1999) Mucosal vaccines: an overview. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, editors. Mucosal immunology 2nd ed. San Diego, CA Academic Press pp. 741-757.
30. Oishi K, Koles NL, Guelde G, Pollack M, (1992) Antibacterial and protective properties of monoclonal antibodies reactive with Escherichia coli O111:B4 lipopolysaccharide: relation to antibody isotype and complement-fixing activity. J Infect Dis 165: 34-45.