Age differences in the neural representation of working memory revealed by multi-voxel pattern analysis

Frontiers in Human Neuroscience

Volumn 4, Issue , 2010, Pages

  Carp, Joshua ^a   Gmeindl, Leon ^b   Reuter Lorenz, Patricia A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Aging; Compensation; Dedifferentiation; fMRI; Multi voxel pattern analysis; Working memory

Indexed keywords

ACCURACY; ADULT; AGE; AGED; ANALYTIC METHOD; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DEPTH PERCEPTION; FEMALE; HUMAN; HUMAN EXPERIMENT; INFORMATION RETRIEVAL; MALE; MENTAL LOAD; MENTAL TASK; MULTI VOXEL PATTERN ANALYSIS; PARIETAL CORTEX; PREFRONTAL CORTEX; REACTION TIME; SENSORY CORTEX; VERBAL MEMORY; VISUAL CORTEX; WORKING MEMORY;

EID: 79953003175     PISSN: 16625161     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2010.00217     Document Type: Article

References (44)

1. Baltes, P. B., and Lindenberger, U. (1997). Emergence of a powerful connection between sensory and cognitive functions across the adult life span: a new window to the study of cognitive aging? Psychol. Aging 12, 12-21.
2. Bellis, T. J., Nicol, T., and Kraus, N. (2000). Aging affects hemispheric asymmetry in the neural representation of speech sounds. J. Neurosci. 20, 791-797.
3. Cabeza, R. (2002). Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol. Aging 17, 85-100.
4. Cabeza, R., Anderson, N., Locantore, J., and McIntosh, A. (2002). Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage 17, 1394-1402.
5. Cappell, K., Gmeindl, L., and Reuter-Lorenz, P. (2010). Age differences in prefontal recruitment during verbal working memory maintenance depend on memory load. Cortex 46, 462-473.
6. Carp, J., Park, J., Polk, T., and Park, D. (2010). Age differences in neural distinctiveness revealed by multi-voxel pattern analysis. Neuroimage. doi:10.1016/j.neuroimage.2010.04.267 [Epub ahead of print].
7. Dale, A. M. (1999). Optimal experimental design for event-related fMRI. Hum. Brain Mapp. 8, 109-114.
8. Daselaar, S., Rombouts, S., Veltman, D., Raaijmakers, J., and Jonker, C. (2003). Similar network activated by young and old adults during the acquisition of a motor sequence. Neurobiol. Aging 24, 1013-1019.
9. Dinstein, I., Gardner, J. L., Jazayeri, M., and Heeger, D. J. (2008). Executed and observed movements have different distributed representations in human aIPS. J. Neurosci. 28, 11231-11239.
10. Duverne, S., Motamedinia, S., and Rugg, M. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cereb. Cortex 19, 733-744.
11. Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. P., Frith, C. D., and Frackowiak, R. S. J. (1995). Statistical parametric maps in functional imaging: a general linear approach. Hum. Brain Mapp. 2, 189-210.
12. Haushofer, J., Livingstone, M., and Kanwisher, N. (2008). Multivariate prepatterns in object-selective cortex dissociate perceptual and physical shape similarity. PLoS Biol. 6, e187. doi: 10.1371/journal.pbio.0060187.
13. Haxby, J., Gobbini, I., Furey, M., Ishai, A., Schouten, J., and Pietrini, P. (2001). Distributed and overlapping representations of faces and objects in ventral temporal cortex. Science 293, 2425-2430.
14. Haynes, J. D., and Rees, G. (2006). Decoding mental states from brain activity in humans. Nat. Rev. Neurosci. 7, 523-534.
15. Hua, T., Li, X., He, L., Zhou, Y., Wang, Y., and Leventhal, A. G. (2006). Functional degradation of visual cortical cells in old cats. Neurobiol. Aging 27, 155-162.
16. Hutchinson, S., Kobayashi, M., Horkan, C. M., Pascual-Leone, A., Alexander, M. P., and Schlaug, G. (2002). Age-related differences in movement representation. Neuroimage 17, 1720-1728.
17. Jonides, J., Schumacher, E., Smith, E., Lauber, E., Awh, E., Minoshima, S., and Koeppe, R. (1997). Verbal working memory load affects regional brain activation as measured by PET. J. Cogn. Neurosci. 9, 462-475.
18. Kriegeskorte, N., Goebel, R., and Bandettini, P. (2006). Information-based functional brain mapping. Proc. Natl. Acad. Sci. U.S.A. 103, 3863-3868.
19. Leventhal, A. G., Wang, Y., Pu, M., Zhou, Y., and Ma, Y. (2003). GABA and its agonists improved visual cortical function in senescent monkeys. Science 300, 812-815.
20. Li, S., Lindenberger, U., and Sikström, S. (2001). Aging cognition: from neuromodulation to representation. Trends Cogn. Sci. (Regul. Ed.) 5, 479-486.
21. Li, S.-C., and Sikström, S. (2002). Integrative neurocomputational perspectives on cognitive aging, neuromodulation, and representation. Neurosci. Biobehav. Rev. 26, 795-808.
22. Lindenberger, U., and Baltes, P. B. (1994). Sensory functioning and intelligence in old age: a strong connection. Psychol. Aging 9, 339-355.
23. Mattay, V., Fera, F., Tessitore, A., Hariri, A., Berman, K., Das, S., Meyer-Lindenberg, A., Goldberg, T., Callicott, J., and Weinberger, D. (2006). Neurophysiological correlates of age-related changes in working memory capacity. Neurosci. Lett. 392, 32-37.
24. Mattay, V. S., Fera, F., Tessitore, A., Hariri, A. R., Das, S., Callicott, J. H., and Weinberger, D. R. (2002). Neurophysiological correlates of age-related changes in human motor function. Neurology 58, 630-635.
25. McEvoy, L. K., Pellouchoud, E., Smith, M. E., and Gevins, A. (2001). Neurophysiological signals of working memory in normal aging. Cogn. Brain Res. 11, 363-376.
26. Miller, S., Celone, K., DePeau, K., Diamond, E., Dickerson, B., Rentz, D., Pihlajamäki, M., and Sperling, R. (2008). Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proc. Natl. Acad. Sci. U.S.A. 105, 2181-2186.
27. Norman, K. A., Polyn, S. M., Detre, G. J., and Haxby, J. V. (2006). Beyond mind-reading: multi-voxel pattern analysis of fMRI data. Trends Cogn. Sci. (Regul. Ed.) 10, 424-430.
28. Park, D. C., Polk, T. A., Park, R., Minear, M., Savage, A., and Smith, M. R. (2004). Aging reduces neural specialization in ventral visual cortex. Proc. Natl. Acad. Sci. U.S.A. 101, 13091-13095.
29. Park, D. C., and Reuter-Lorenz, P. (2009). The adaptive brain: aging and neurocognitive scaffolding. Annu. Rev. Psychol. 60, 173-196.
30. Park, J., Carp, J., Hebrank, A., Park, D., and Polk, T. (2010). Neural specificity pre-dicts fluid processing ability in older adults. J. Neurosci. 30, 9253-9259.
31. Peelen, M. V., Wiggett, A. J., and Downing, P. E. (2006). Patterns of fMRI activity dissociate overlapping functional brain areas that respond to biological motion. Neuron 49, 815-822.
32. Persson, J., Lustig, C., Nelson, J., and Reuter-Lorenz, P. (2007). Age differences in deactivation: a link to cognitive control? J. Cogn. Neurosci. 19, 1021-1032.
33. Postle, B. R., Zarahn, E., and D'Esposito, M. (2000). Using event-related fMRI to assess delay-period activity during performance of spatial and nonspatial working memory tasks. Brain Res. Brain Res. Protoc. 5, 57-66.
34. Rajah, N., and D'Esposito, M. (2005). Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory. Brain 128, 1964-1983.
35. Reuter-Lorenz, P., and Cappell, K. (2008). Neurocognitive aging and the compensation hypothesis. Curr. Dir. Psychol. Sci. 17, 177-182.
36. Reuter-Lorenz, P., and Park, D. (2010). Human neuroscience and the aging mind: a new look at old problems. J Gerontol. 65, 405-415.
37. Reuter-Lorenz, P., Stanczak, L., and Miller, A. (1999). Neural recruitment and cognitive aging: two hemispheres are better than one, especially as you age. Psychol. Sci. 10, 494-500.
38. Reuter-Lorenz, P. A., Jonides, J., Smith, E. E., Hartley, A., Miller, A., Marshuetz, C., and Koeppe, R. A. (2000). Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET. J. Cogn. Neurosci. 12, 174-187.
39. Reuter-Lorenz, P. A., and Lustig, C. (2005). Brain aging: reorganizing discoveries about the aging mind. Curr. Opin. Neurobiol. 15, 245-251.
40. Rypma, B., and D'Esposito, M. (2000). Isolating the neural mechanisms of age-related changes in human working memory. Nat. Neurosci. 3, 509-515.
41. Rypma, B., Prabhakaran, V., Desmond, J. E., Glover, G. H., and Gabrieli, J. D. (1999). Load-dependent roles of frontal brain regions in the maintenance of working memory. Neuroimage 9, 216-226.
42. Schmolesky, M. T., Wang, Y., Pu, M., and Leventhal, A. G. (2000). Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys. Nat. Neurosci. 3, 384-390.
43. Schneider-Garces, N., Gordon, B., Brumback-Peltz, C., Shin, E., Lee, Y., Sutton, B., Maclin, E., Gratton, G., and Fabiani, M. (2010). Span, CRUNCH, and beyond: working memory capacity and the aging brain. J. Cogn. Neurosci. 22, 655-669.
44. Smith, E. E., Jonides, J., and Koeppe, R. A. (1996). Dissociating verbal and spatial working memory using PET. Cereb. Cortex 6, 11-20.