RalA and RalB differentially regulate development of epithelial tight junctions

Molecular Biology of the Cell

Volumn 22, Issue 24, 2011, Pages 4787-4800

  Hazelett, C Clayton ^a   Sheff, David ^a   Yeaman, Charles ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXOCYST; RAL PROTEIN; RALA PROTEIN; RALB PROTEIN; SHORT HAIRPIN RNA; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ARTICLE; BIOGENESIS; CELL COMPOSITION; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CELL POLARITY; CELL SEPARATION; CONTROLLED STUDY; ENDOCYTOSIS; EPITHELIUM CELL; GENE SILENCING; HUMAN; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE;

ANIMALS; CELL LINE; DOGS; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HUMANS; RAL GTP-BINDING PROTEINS; TIGHT JUNCTIONS;

EID: 84055211694     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-07-0657     Document Type: Article

References (52)

1. Angelow S, Ahlstrom R, Yu AS (2008). Biology of claudins. Am J Physiol Renal Physiol 295, F867-F876.
2. Balasubramanian N, Meier JA, Scott DW, Norambuena A, White MA, Schwartz MA (2010). RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Curr Biol 20, 75-79.
3. Barth AI, Pollack AL, Altschuler Y, Mostov KE, Nelson WJ (1997). NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J Cell Biol 136, 693-706. (Pubitemid 27083769)
4. Blankenship JT, Fuller MT, Zallen JA (2007). The Drosophila homolog of theExo84 exocyst subunit promotes apical epithelial identity. J Cell Sci 120, 3099-3110. (Pubitemid 47517092)
5. Bodemann BO et al. (2011). RalB and the exocyst mediate the cellularstarvation response by direct activation of autophagosome assembly. Cell 144, 253-267.
6. Bodemann BO, White MA (2008). Ral GTPases and cancer: linchpin support of the tumorigenic platform. Nat Rev Cancer 8, 133-140. (Pubitemid 351187648)
7. Bryant DM, Datta A, Rodriguez-Fraticelli AE, Peranen J, Martin-Belmonte F, Mostov KE (2010). A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol 12, 1035-1045.
8. Cascone I, Selimoglu R, Ozdemir C, Del Nery E, Yeaman C, White M, Camonis J (2008). Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. EMBO J 27, 2375-2387.
9. Cereijido M, Robbins ES, Dolan WJ, Rotunno CA, Sabatini DD (1978). Polarized monolayers formed by epithelial cells on a permeable and translucent support. J Cell Biol 77, 853-880. (Pubitemid 8347746)
10. Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR (2007). Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell 13, 391-404. (Pubitemid 47308676)
11. Chien Y et al. (2006). RalB GTPase-mediated activation of the IkappaB familykinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127, 157-170. (Pubitemid 44472624)
12. Diamond JM (1977). Twenty-first Bowditch Lecture. The epithelial junction: bridge, gate, and fence. Physiologist 20, 10-18.
13. Fukai S, Matern HT, Jagath JR, Scheller RH, Brunger AT (2003). Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. EMBO J 22, 3267-3278. (Pubitemid 36834857)
14. Gonzalez-Mariscal L, Contreras RG, Bolivar JJ, Ponce A, Chavez De Ramirez B, Cereijido M (1990). Role of calcium in tight junction formation between epithelial cells. Am J Physiol 259, C978-C986.
15. Graeve L, Drickamer K, Rodriguez-Boulan E (1989). Polarized endocytosis by Madin-Darby canine kidney cells transfected with functional chicken liver glycoprotein receptor. J Cell Biol 109, 2809-2816. (Pubitemid 20011908)
16. Griepp EB, Dolan WJ, Robbins ES, Sabatini DD (1983). Participation of plasma membrane proteins in the formation of tight junctions by cultured epithelial cells. J Cell Biol 96, 693-702. (Pubitemid 13131330)
17. Grindstaff KK, Yeaman C, Anandasabapathy N, Hsu SC, Rodriguez-Boulan E, Scheller RH, Nelson WJ (1998). Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell 93, 731-740. (Pubitemid 28257580)
18. Gumbiner B, Simons K (1986). A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol 102, 457-468. (Pubitemid 16140806)
19. Hsu SC, Ting AE, Hazuka CD, Davanger S, Kenny JW, Kee Y, Scheller RH (1996). The mammalian brain rsec6/8 complex. Neuron 17, 1209-1219. (Pubitemid 27021105)
20. Ivanov AI, McCall IC, Parkos CA, Nusrat A (2004). Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex. Mol Biol Cell 15, 2639-2651. (Pubitemid 38691854)
21. Jin R, Junutula JR, Matern HT, Ervin KE, Scheller RH, Brunger AT (2005). Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. EMBO J 24, 2064-2074. (Pubitemid 40961791)
22. Jou TS, Nelson WJ (1998). Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J Cell Biol 142, 85-100.
23. Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (1997). Subunit structure of the mammalian exocyst complex. Proc Natl Acad Sci USA 94, 14438-14443. (Pubitemid 28041392)
24. Lalli G (2009). RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC. J Cell Sci 122, 1499-1506.
25. Lalli G, Hall A (2005). Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex. J Cell Biol 171, 857-869. (Pubitemid 41746587)
26. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T (2006). Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell 10, 839-850. (Pubitemid 43779110)
27. Mandel LJ, Bacallao R, Zampighi G (1993). Uncoupling of the molecular "fence" and paracellular "gate" functions in epithelial tight junctions.Nature 361, 552-555. (Pubitemid 23055620)
28. Marrs JA, Napolitano EW, Murphy-Erdosh C, Mays RW, Reichardt LF, Nelson WJ (1993). Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+,K(+)-ATPase distributions in polarized epithelia. J Cell Biol 123, 149-164. (Pubitemid 23284871)
29. Moskalenko S, Henry DO, Rosse C, Mirey G, Camonis JH, White MA (2002). The exocyst is a Ral effector complex. Nat Cell Biol 4, 66-72. (Pubitemid 34071982)
30. Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2003). Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem 278, 51743-51748. (Pubitemid 38020420)
31. Ohba Y, Kurokawa K, Matsuda M (2003). Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J 22, 859-869. (Pubitemid 36227788)
32. Pasdar M, Nelson WJ (1988). Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. II. Morphological analysis. J Cell Biol 106, 687-695. (Pubitemid 18089969)
33. Rosse C, Hatzoglou A, Parrini MC, White MA, Chavrier P, Camonis J (2006). RalB mobilizes the exocyst to drive cell migration. Mol Cell Biol 26, 727-734. (Pubitemid 43089782)
34. Sheff DR, Daro EA, Hull M, Mellman I (1999). The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions. J Cell Biol 145, 123-139. (Pubitemid 29177680)
35. Shipitsin M, Feig LA (2004). RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells. Mol Cell Biol 24, 5746-5756. (Pubitemid 38787960)
36. Siliciano JD, Goodenough DA (1988). Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells. J Cell Biol 107, 2389-2399.
37. Sommer B, Oprins A, Rabouille C, Munro S (2005). The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster. J Cell Biol 169, 953-963. (Pubitemid 41002871)
38. Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA (2010). RalA suppresses early stages of Ras-induced squamous cell carcinoma progression. Oncogene 29, 45-55.
39. Spiczka KS, Yeaman C (2008). Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration. J Cell Sci 121, 2880-2891.
40. St. Johnston D, Ahringer J (2010). Cell polarity in eggs and epithelia: parallels and diversity. Cell 141, 757-774.
41. Takakuwa R, Kokai Y, Kojima T, Akatsuka T, Tobioka H, Sawada N, Mori M (2000). Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B. Exp Cell Res 257, 238-244. (Pubitemid 30390474)
42. Takaya A et al. (2007). R-Ras regulates exocytosis by Rgl2/Rlf-mediatedactivation of RalA on endosomes. Mol Biol Cell 18, 1850-1860. (Pubitemid 46717565)
43. Takaya A, Ohba Y, Kurokawa K, Matsuda M (2004). RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells. Mol Biol Cell 15, 2549-2557. (Pubitemid 38691846)
44. TerBush DR, Maurice T, Roth D, Novick P (1996). The exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.EMBO J 15, 6483-6494. (Pubitemid 26413781)
45. Tsukita S, Yamazaki Y, Katsuno T, Tamura A (2008). Tight junction-based epithelial microenvironment and cell proliferation. Oncogene 27, 6930-6938.
46. Umeda K, Ikenouchi J, Katahira-Tayama S, Furuse K, Sasaki H, Nakayama M, Matsui T, Tsukita S, Furuse M (2006). ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 126, 741-754. (Pubitemid 44233624)
47. van Dam EM, Robinson PJ (2006). Ral: mediator of membrane trafficking. Int J Biochem Cell Biol 38, 1841-1847. (Pubitemid 44425246)
48. Van Itallie CM, Anderson JM (2006). Claudins and epithelial paracellular transport. Annu Rev Physiol 68, 403-429.
49. Vega IE, Hsu SC (2001). The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth. J Neurosci 21, 3839-3848. (Pubitemid 32466476)
50. Yeaman C (2003). Ultracentrifugation-based approaches to study regulation of Sec6/8 (exocyst) complex function during development of epithelial cell polarity. Methods 30, 198-206.
51. Yeaman C, Grindstaff KK, Nelson WJ (2004). Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells. J Cell Sci 117, 559-570. (Pubitemid 38240197)
52. Yu D, Turner JR (2008). Stimulus-induced reorganization of tight junction structure: the role of membrane traffic. Biochim Biophys Acta 1778, 709-716. (Pubitemid 351317798)