CaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2011, Pages 4665-4668

  Hashambhoy, Yasmin L ^a   Winslow, Raimond L ^a   Greenstein, Joseph L ^a  

^a Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DEPOLARIZATION; DISEASES; STOCHASTIC MODELS; STOCHASTIC SYSTEMS;

ACTION POTENTIALS; CARDIAC MYOCYTES; COMPUTATIONAL MODEL; EARLY AFTER DEPOLARIZATION; EXCITATION - CONTRACTION COUPLINGS; MEMBRANE DEPOLARIZATION; PATHOLOGICAL CONDITIONS; STOCHASTIC SIMULATIONS;

SODIUM;

EID: 84055199871     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2011.6091155     Document Type: Conference Paper

References (18)

1. C. Bezzina, et al., "A Single Na+ Channel Mutation Causing Both Long-QT and Brugada Syndromes," Circ Res, vol. 85, pp. 1206-1213, December 3, 1999 1999.
2. Q. Chen, et al., "Genetic basis and molecular mechanism for idiopathic ventricular fibrillation," Nature, vol. 392, pp. 293-296, 1998.
3. T. Aiba, et al., "Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes," Cardiovasc Res, vol. 85, pp. 454-63, Feb 1 2010.
4. L.-H. Xie, F. Chen, H. S. Karagueuzian, and J. N. Weiss, "Oxidative Stress-Induced Afterdepolarizations and Calmodulin Kinase II Signaling," Circ Res, vol. 104, pp. 79-86, January 2, 2009 2009.
5. U. Kirchhefer, W. Schmitz, H. Scholz, and J. Neumann, "Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts," Cardiovasc Res, vol. 42, pp. 254-61, Apr 1999.
6. I. Deschenes, et al., "Isoform-Specific Modulation of Voltage-Gated Na+ Channels by Calmodulin," Circ Res, vol. 90, pp. e49-57, March 8, 2002 2002.
7. V. A. Maltsev, V. Reznikov, N. A. Undrovinas, H. N. Sabbah, and A. Undrovinas, "Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences," Am J Physiol Heart Circ Physiol, vol. 294, pp. H1597-1608, April 1, 2008 2008.
8. + channels," Journal of Clinical Investigation, vol. 116, pp. 3127-3138, 2006.
9. E. Grandi, et al., "Simulation of Ca-Calmodulin-Dependent Protein Kinase II on Rabbit Ventricular Myocyte Ion Currents and Action Potentials," Biophys. J., vol. 93, pp. 3835-3847, December 1, 2007 2007.
10. Y. L. Hashambhoy, J. L. Greenstein, and R. L. Winslow, "Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model," J Mol Cell Cardiol, vol. 49, pp. 617-24, Oct 2010.
11. J. L. Greenstein and R. L. Winslow, "An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release," Biophys J, vol. 83, pp. 2918-45, Dec 2002.
12. Y. L. Hashambhoy, R. L. Winslow, and J. L. Greenstein, "CaMKIIinduced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study," Biophys J, vol. 96, pp. 1770-85, Mar 4 2009.
13. T. Nagatomo, et al., "Temperature dependence of early and late currents in human cardiac wild-type and long Q-T Delta KPQ Na+ channels," Am J Physiol Heart Circ Physiol, vol. 275, pp. H2016-2024, December 1, 1998 1998.
14. K. T. Murray, T. Anno, P. B. Bennett, and L. M. Hondeghem, "Voltage clamp of the cardiac sodium current at 37 degrees C in physiologic solutions," Biophys. J., vol. 57, pp. 607-613, March 1, 1990 1990.
15. C. R. Valdivia, et al., "Increased late sodium current in myocytes from a canine heart failure model and from failing human heart," Journal of Molecular and Cellular Cardiology, vol. 38, pp. 475-483, 2005.
16. G.-R. Li, C.-P. Lau, A. Ducharme, J.-C. Tardif, and S. Nattel, "Transmural action potential and ionic current remodeling in ventricles of failing canine hearts," Am J Physiol Heart Circ Physiol, vol. 283, pp. H1031-1041, September 1, 2002 2002.
17. S. Wagner, et al., "Reactive Oxygen Species-Activated Ca/Calmodulin Kinase II{delta} Is Required for Late INa Augmentation Leading to Cellular Na and Ca Overload," Circ Res, vol. 108, pp. 555-65, Mar 4 2011.
18. S. Rajamani, N. El-Bizri, J. C. Shryock, J. C. Makielski, and L. Belardinelli, "Use-dependent block of cardiac late Na(+) current by ranolazine," Heart Rhythm, vol. 6, pp. 1625-31, Nov 2009.