Targeting methionine auxotrophy in cancer: Discovery & exploration

Expert Opinion on Biological Therapy

Volumn 12, Issue 1, 2012, Pages 53-61

  Agrawal, Vaidehi ^a,b   Alpini, Sarah E J ^a   Stone, Everett M ^c   Frenkel, Eugene P ^d   Frankel, Arthur E ^a,b  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c The University of Texas at Austin   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cancer therapy methionine; Methioninase; Methionine auxotrophy; RBC encapsulation

Indexed keywords

CISPLATIN; CYSTEMUSTINE; DOXORUBICIN; FLUOROURACIL; METHIONINE; RECOMBINANT METHIONINE GAMMA LYASE; VINCRISTINE;

AUXOTROPHY; BIOENGINEERING; BREAST CANCER; CANCER CELL; CANCER THERAPY; COLORECTAL CANCER; COLORECTAL CARCINOMA; DIET RESTRICTION; ENCAPSULATION; ERYTHROCYTE; GLIOMA; HUMAN; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LEUKOPENIA; MELANOMA; NEUROBLASTOMA; NEUTROPENIA; NONHUMAN; REVIEW; STOMACH CANCER; THROMBOCYTOPENIA;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOENGINEERING; CELL LINE, TUMOR; ERYTHROCYTES; HUMANS; IMMUNE SYSTEM; MEDICAL ONCOLOGY; METHIONINE; MICE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; NEOPLASMS; POLYETHYLENE GLYCOLS; PSEUDOMONAS PUTIDA; RATS;

EID: 84055199228     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.636349     Document Type: Review

References (52)

1. Kroemer G, Pouyssegur J. Tumor cell metabolism: Cancer's Achilles' Heel. Cancer Cell 2008;13:472-82 (Pubitemid 351766797)
2. Deberardinis RJ, Sayed N, Ditsworth D, et al. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 2008;18:54-61 (Pubitemid 351694453)
3. Dinndorf PA, Gootenberg J, Cohen MH, et al. FDA drug approval summary: Pegaspargase (Oncaspar) for the first-line treatment of children with acute lymphoblastic leukemia (ALL). Oncologist 2007;12:991-8 (Pubitemid 47359142)
4. Taylor CW, Dorr RT, Fanta P, et al. A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumor. Cancer Chemother Pharmacol 2001;47:83-8 (Pubitemid 32664518)
5. Glazer ES, Piccirillo M, Albino V, et al. Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma. J Clin Oncol 2010;28:2220-6
6. Thivat E, Farges MC, Bacin F, et al. Phase II trial of the association of a methionine-free diet with cystemustine therapy in melanoma and glioma. Anticancer Res 2009;29:5235-40
7. Halpern BC, Clark BR, Hardy DN, et al. The effect of replacement of methionine by homocysteine on survival of malignant and normal adult mammalian cells in culture. PNAS 1974;71:1133-6
8. Wilson MJ, Poirier LA. An increased requirement for methionine by transformed rat liver epithelial cells in vitro. Exp Cell Res 1978;11:397-400 (Pubitemid 8307855)
9. Kreis W, Goodenow M. Methionine requirement and replacement by homocysteine in tissue cultures of selected rodent and human malignant and normal cells. Cancer Res 1978;38:2259-62 (Pubitemid 8390861)
10. Hoffman RM, Erbe RW. High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotropic for methionine. PNAS 1976;73:1523-7
11. Tautt JW, Anuszewska EL, Koziorowska JH. Methionine regulation of N-5-methyltetrahydrfolate: homocysteine methyltransferase and its influence on the growth and protein synthesis in normal, neoplastic, and transformed cells in culture. JNCI 1982;69:9-14 (Pubitemid 12052373)
12. Ashe H, Clark BR, Chu F, et al. N5-Methyltetrahydrofolate: homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells. Biochem Biophys Res Commun 1974;57:417-25
13. Jacobsen SJ, North JA, Rao NA, et al. 5-Methyltetradrofolate: synthesis and utilization in normal and SV40-transformed BHK-21 cells. Biochem Biophys Res Commun 1977;76:46-52
14. Kamely D, Littlefield JW, Erbe RW. Regulation of 5-methytetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells. PNAS 1973;70:2585-9
15. Mecham JO, Rowitch D, Wallace D, et al. The metabolic defect of methionine dependence occurs frequently in human tumor cell lines. Biochem Biophys Res Commun 1983;117:429-34 (Pubitemid 14177577)
16. Hoffman RM, Jacobsen SJ, Erbe RW. Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation. PNAS 1979;76:1313-17 (Pubitemid 9143730)
17. Hoffman RM, Jacobsen SJ, Erbe RW. Reversion to methionine independence by malignant rat and SV40-transformed human fibroblasts. Biochem Biophys Res Commun 1978;82:228-34 (Pubitemid 8347403)
18. Fiskerstrand T, Christensen B, Tysnes OB, et al. Development and reversion of methionione dependency in a human glioma cell line: Relation to homocysteine remethylation and cobalamin status. Cancer Res 1994;54:4899-906 (Pubitemid 24289419)
19. Tang B, Mustafa A, Gupta S, et al. Methionine deficient diet induces post-transcriptional downregulation of cystathionine beta-synthase. Nutrition 2010;26:1170-5
20. Pena MM, Melo SP, Xing YY, et al. The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway. J Bio Chem 2009;284:597-607
21. Joseph B, Jeschke G, Goetz BA, et al. Transmembrane gate movements in the type 2 ABC importer BTUCD-F during nucloetide cycle. JBC 2011;published online 27 September 2011; doi: 10.1074/jbc.M111.269472
22. Breillout F, Hadida F, Echinard-Garin P, et al. Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet. Anticancer Res 1987;7(4B):861-7
23. Goseki N, Endo M, Onodera T, et al. Influence of L-methionine-deprived total parenteral nutrition on the tumor tissue and plasma amino acids fraction and the host metabolism: experimental study with sato lung carcinoma-brearing rats. J Exp Med 1989;157:251-60 (Pubitemid 19170537)
24. Epner DE, Morrow S, Wilcox M, et al. Nutrition intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction. Nutr Cancer 2002;42:158-66 (Pubitemid 35253663)
25. Stern PH, Hoffman RM. Enhanced in vitro selective toxicity of chemotherapeutic agents for human Targeting methionine auxotrophy in cancer: discovery & exploration 60 Expert Opin. Biol. Ther. (2012) 12(1) cancer cells based on a metabolic defect. J Natl Cancer Inst 1986;76:629-39
26. Hoshiya Y, Kubota T, Matsuzaki SW, et al. Methionine starvation modulates the efficacy of cisplatin on human breast cancer in nude mice. Anticancer Res 1996;16(6B):3515-18 (Pubitemid 127540812)
27. Goseki N, Yamazaki S, Shimojyu K, et al. Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial. Jpn J Cancer Res 1995;86:484-9
28. Durando X, Thivat E, Farges MC, et al. Optimal Methionine-free diet duration for nutrourea treatment: a phase I clinical trial. Nutr Cancer 2011;60:23-30 (Pubitemid 351186212)
29. Thivat E, Durando X, Demidem A, et al. A methionine-free diet associated with nitrosourea treatment down-regulates methylguanine- DNA methyl transferase activity in patients with metastatic cancer. Anticancer Res 2007;27(4C):2779-84
30. Tan Y, Xu M, Tan X, et al. Overexpression and large-scale production of recombinant l-methioninea- deamino-y-mercaptomethane-lyase for novel anticancer therapy. Protein Expr Purif 1997;9:233-45 (Pubitemid 27210719)
31. Tan Y, Xu M, Hoffman RM. Broad selective efficacy of rMetase and PEG-rMetase on cancer cells in vitro. Anticancer Res 2010;30:793-8
32. Hu J, Cheung NKV. Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs. Int J Cancer 2010;124:1700-6
33. Alfano RW, Leppla SH, Liu S, et al. Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formatin during in vitro morphogenesis. Mol Cancer Res 2009;7:452-61
34. Tan Y, Xinghua S, Mingxu X, et al. Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice. Clin Cancer Res 1999;5:2157-63 (Pubitemid 29399272)
35. Yang Z, Wang J, Yoskioka T, et al. Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates. Clin Cancer Res 2004;10:2131-8 (Pubitemid 38375575)
36. Tan Y, Zavala J, Han Q, et al. Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high stage cancer patients. Anticancer Res 1997;17(5B):3857-60 (Pubitemid 28014950)
37. Tan Y, Zavala J, Xu M, et al. Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients. Anticancer Res 1996;16(6C):3937-42 (Pubitemid 27084948)
38. Tan Y, Xinghua S, Mingxu X, et al. Polyethylene glycol conjugation of recombinant methioninase for cancer therapy. Protein Expr Purif 1998;12:45-52 (Pubitemid 28361968)
39. Yang Z, Wang J, Quan L, et al. PEGylation confers greately extended half-life and attenuated immunogenicity to recombinant methioninase in primates. Cancer Res 2004;64(18):6673-8 (Pubitemid 39297929)
40. Cantor JR, Yoo TH, Dixit A, et al. Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. PNAS 2011;108:1272-7
41. Alpar HO, Lewis DA. Therapeutic efficacy of asparaginase encapsulated in intact erythrocytes. Biochem Pharmacol 1985;34:257-61 (Pubitemid 15153420)
42. Ataullakhanov FI, Vitvitskii VM, Zhabotinskii AM, et al. Permeability of human erythrocytes to asparagine. Biokhimiia 1986;50:1733-7 (Pubitemid 16219985)
43. Agrawal V, Woo JH, Borthakur G, et al. Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia. Protein Pept Lett 2011; In press
44. Domenech C, Thomas X, Chabaud S, et al. L-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial. Br J Haematol 2011;153:58-65
45. Borek E, Srinivasan PR. The methylation of nucleic acids. Annu Rev Biochem 1966;35:275-98
46. Graham ML. Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev 2003;55:1293-302 (Pubitemid 37464563)
47. Glazer ES, Piccirillo M, Albino V, et al. Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma. J Clin Oncol 2010;28:2220-6
48. Ensor CM, Holtsberg FW, Bomalaski JS, et al. Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer Res 2007;62:5443-50
49. Rytting M. Peg-asparaginase for acute lymphoblastic leukemia. Expert Opin Biol Ther 2010;10:833-9
50. Capizzi RL, Bertino JR, Skeel RT, et al. L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. Ann Intern Med 1971;74:893-901
51. Clarkson B, Krakoff I, Burchenal J, et al. Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors. Cancer 1969;25:279-301
52. Ascierto PA, Scala S, Castello G, et al. Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. J Clin Oncol 2005;23:7660-8 (Pubitemid 46291831)