Glutamine and the tumor microenvironment: Understanding the mechanisms that fuel cancer progression

Cancer Biology and Therapy

Volumn 12, Issue 12, 2011, Pages 1098-1100

  Albanese, Chris ^a   Machado, Fabiana S ^b   Tanowitz, Herbert B ^c  

^a GEORGETOWN UNIVERSITY   (United States)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Autophagy; Breast cancer; Fibroblast; Metabolism; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMMONIA; CAVEOLIN 1; GLUTAMATE DEHYDROGENASE; GLUTAMINE; TRICARBOXYLIC ACID;

AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CATABOLISM; CELL DEATH; CELL METABOLISM; CELL PROLIFERATION; EPITHELIUM CELL; FIBROBLAST; NOTE; TUMOR MICROENVIRONMENT;

AUTOPHAGY; GLUTAMINE; HUMANS; MITOCHONDRIA; NEOPLASMS;

EID: 84055184902     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.12.18856     Document Type: Note

References (7)

1. Ko YH, Lin Z, Flomenberg N, Pestell R, Howell A, Sotgia F, et al. Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: Implications for preventing chemotherapy resistance. Cancer Biol Ther 2011; In press.
2. DeBerardinis RJ, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010; 29:313-24; PMID:19881548; http://dx.doi.org/10.1038/onc.2009.358
3. Eng CH, Yu K, Lucas J, White E, Abraham RT. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal 2010; 3:ra31; PMID:20424262; http://dx.doi.org/10.1126/scisignal. 2000911
4. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-33; PMID:19460998; http://dx.doi.org/10.1126/ science.1160809
5. Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, Chiavarina B, Bonuccelli G, Casey T, et al. The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox. Cell Cycle 2010; 9:4297-306; PMID:21051947; http://dx.doi.org/10.4161/ cc.9.21. 13817
6. Sonveaux P, Vegran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 2008; 118:3930-42; PMID: 19033663
7. Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med 2011; 17:1498-503; PMID:22037646; http://dx.doi.org/10.1038/nm.2492