Cytomegalovirus reactivation and mortality during critical illness: A $64,000 question

Critical Care Medicine

Volumn 37, Issue 8, 2009, Pages 2475-2476

  Cook, Charles H ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Critical illness; Cytomegalovirus; Infection; Reactivation

Indexed keywords

CRITICAL ILLNESS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EDITORIAL; HUMAN; INCIDENCE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SEPSIS; VIRUS REACTIVATION;

EID: 68249098640     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181ad932e     Document Type: Editorial

References (18)

1. Kalil AC, Florescu DF: Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. Crit Care Med 2009; 37:2350-2358
2. Cook CH, Martin LC, Yenchar JK, et al: Occult herpes family viral infections are endemic in critically ill surgical patients. Crit Care Med 2003; 31:1923-1929
3. Cook CH, Yenchar JK, Kraner TO, et al: Occult herpes family viruses may increase mortality in critically ill surgical patients. Am J Surg 1998; 176:357-360
4. Rubin RH: Impact of cytomegalovirus infection on organ transplant recipients. Rev Infect Dis 1990; 12 Suppl 7:S754-S766
5. Limaye AP, Kirby KA, Rubenfeld GD, et al: Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 2008; 300:413-422
6. Cook C, Zhang X, McGuinness B, et al: Intra-abdominal bacterial infection reactivates latent pulmonary cytomegalovirus in immunocompetent mice. J Infect Dis 2002; 185: 1395-1400
7. Staras SAS, Dollard SC, Radford KW, et al: Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis 2006; 43:1143-1151
8. Cook CH, Trgovcich J, Zimmerman PD, et al: Lipopolysaccharide, tumor necrosis factor alpha, or interleukin-1beta triggers reactivation of latent cytomegalovirus in immuno-competent mice. J Virol 2006; 80:9151-9158
9. Kutza AS, Muhl E, Hackstein H, et al: High incidence of active cytomegalovirus infection among septic patients. Clin Infect Dis 1998; 26:1076-1082
10. Domart Y, Trouillet JL, Fagon JY, et al: Incidence and morbidity of cytomegaloviral infection in patients with mediastinitis following cardiac surgery. Chest 1990; 97:18-22. Comment in: Chest 1990; 97:3
11. Heininger A, Jahn G, Engel C, et al: Human cytomegalovirus infections in nonimmuno-suppressed critically ill patients. Crit Care Med 2001; 29:541-547
12. Jaber S, Chanques G, Borry J, et al: Cytomegalovirus infection in critically ill patients: Associated factors and consequences. Chest 2005; 127:233-241
13. von Muller L, Klemm A, Weiss M, et al: Active cytomegalovirus infection in patients with septic shock. Emerging Infectious Diseases 2006; 12:1517-1522
14. Ziemann M, Sedemund-Adib B, Reiland P, et al: Increased mortality in long-term intensive care patients with active cytomegalovirus infection. Crit Care Med 2008; 36:3145-3150
15. Cook CH, Zhang Y, Sedmak DD, et al: Pulmonary cytomegalovirus reactivation causes pathology in immunocompetent mice. Crit Care Med 2006; 34:842-849
16. Chatterjee SN, Fiala M, Weiner J, et al: Primary cytomegalovirus and opportunistic infections. Incidence in renal transplant recipients. JAMA 1978; 240:2446-2449
17. von Muller L, Klemm A, Durmus N, et al: Cellular immunity and active human cytomegalovirus infection in patients with septic shock. J Infect Dis 2007; 196:1288-1295
18. von Müller L, Mertens T: Human cytomegalovirus infection and antiviral immunity in septic patients without canonical immuno-suppression. Med Microbiol Immunol 2008; 197:75-82. Epub 2008 Mar 8