The influence of degree-of-branching and molecular mass on the interaction between dextran and Concanavalin A in hydrogel preparations intended for insulin release

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 80, Issue 1, 2012, Pages 143-148

  Benzeval, Ian ^a   Bowyer, Adrian ^b   Hubble, John ^a  

^a University of Bath   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

Branching; Concanavalin; Dextran; Hydrogel; Insulin

Indexed keywords

CONCANAVALIN A; DEXTRAN; INSULIN;

ARTICLE; BINDING AFFINITY; CARBOHYDRATE ANALYSIS; CHEMICAL STRUCTURE; DEGREE OF BRANCHING; HYDROGEL; INSULIN RELEASE; MICROCALORIMETRY; MOLECULAR WEIGHT; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

CALORIMETRY; CHEMISTRY, PHARMACEUTICAL; CONCANAVALIN A; DEXTRANS; HYDROGEL; INSULIN; LECTINS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR WEIGHT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 83955161680     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.08.009     Document Type: Article

References (23)

1. R. Zhang, M. Tang, A. Bowyer, R. Eisenthal, and J. Hubble Synthesis and characterization of a d-glucose sensitive hydrogel based on CM-dextran and Concanavalin A React. Funct. Polym. 66 2006 757 767 (Pubitemid 43928835)
2. M. Tang, R. Zhang, A. Bowyer, R. Eisenthal, and J. Hubble A reversible hydrogel membrane for controlling the delivery of macromolecules Biotechnol. Bioeng. 8 2002 47 53
3. A. Jeanes, W.C. Haynes, C.A. Wilham, J.C. Rankin, E.H. Melvin, M.J. Austin, J.E. Cluskey, B.E. Fisher, H.M. Tsuchiya, and C.E. Rist Characterization and classification of dextrans from 96 strains of bacteria J. Am. Chem. Soc. 76 1954 5041 5052
4. A. Jeanes, and C.A. Wilham Periodate oxidation of dextran J. Am. Chem. Soc. 72 1950 2655 2657
5. Sigma-Aldrich Data Sheet. http://www.sigmaaldrich.com/etc./medialib/docs/ Sigma-Aldrich/Product-Information-Sheet/d5251pis.Par.0001.File.tmp/d5251pis.pdf, 2009 (accessed 02.11.09).
6. D. Kim, J.F. Robyt, S.-Y. Lee, J.-H. Lee, and Y.-M. Kim Dextran molecular size and degree of branching as a function of sucrose concentration, pH and temperature of reaction of leuconostoc mesenteroides B-512FMCM dextransucrase Carbohydr. Res. 338 2003 1183 1189 (Pubitemid 36579026)
7. D. Williams, and I. Fleming Spectroscopic Methods in Organic Chemistry sixth ed. 2008 McGraw-Hill Higher Education Maidenhead
8. W.M. Pasika, and L.H. Cragg The detection and estimation of branching in dextran by proton magnetic resonance spectroscopy Can. J. Chem. 41 1962 293 299
9. 1H NMR spectra Carbohydr. Res. 74 1979 77 92
10. 1H NMR study of distribution of functional groups in carboxymethyl dextran Zhurnal Prikl. Him. 72 1999 701 703
11. N.W.H. Cheetham, and E. Fiala-Beer Dextran structural details from high-field proton NMR spectroscopy Carbohydr. Polym. 14 1991 149 158 (Pubitemid 21736288)
12. N.H. Maina, M. Tenkanen, H. Maaheimo, R. Juvonen, and L. Virrki NMR spectroscopic analysis of exopolysaccharides produced by leuconostoc citreum and weissella confuse Carbohydr. Res. 343 2008 1446 1455
13. L. MicroCal, VP-ITC MicroCalorimeter User's Manual, MicroCal, Northampton, MA.
14. T. Wiseman, S. Williston, J.F. Brandts, and L.-N. Lin Rapid measurement of binding constants and heats of binding using a new titration calorimeter Anal. Biochem. 179 1989 131 137 (Pubitemid 19149635)
15. A. Cornish-Bowden Fundamentals of Enzyme Kinetics first ed. 1979 Butterworths Southampton
16. J.M. Baldwin A model of co-operative oxygen binding to haemoglobin Br. Med. Bull. 32 1976 213 218
17. D. Michel Co-operative equilibrium curves generated by ordered ligand binding to multi-site molecules Biophys. Chem. 129 2007 284 288 (Pubitemid 47208532)
18. D. Voet, and J.G. Voet Sugars and Polysaccharides second ed. Biochemistry 1995 Wiley New York City
19. S.L. Mangold, and M.J. Cloninger Binding of monomeric and dimeric Concanavalin A to mannose-functionalized dendrimers Org. Biomol. Chem. 4 2006 2458 2465 (Pubitemid 43882769)
20. G.N. Reeke, J.W. Becker, G.M. Edelman, and The Covalent The covalent and three-dimensional structure of Concanavalin A: IV. Atomic coordinates, hydrogen bonding and quaternary structure J. Biol. Chem. 250 1975 1525 1547
21. C.E. Ioan, T. Aberle, and W. Burchard Structure properties of dextran. 2. Dilute solution Macromolecules 33 2000 5730 5739
22. W.M. Saltzman Drug Delivery: Engineering Principles for Drug Therapy first ed. 2001 Oxford University Press New York
23. S. Elgavish, and B. Shaanan Lectin-carbohydrate interactions: different folds, common recognition principles Trends Biochem. Sci. 22 1997 462 467 (Pubitemid 27515911)