HSP70i is a critical component of the immune response leading to vitiligo

Pigment Cell and Melanoma Research

Volumn 25, Issue 1, 2012, Pages 88-98

  Mosenson, Jeffrey A ^a   Zloza, Andrew ^a   Klarquist, Jared ^a   Barfuss, Allison J ^a   Guevara Patino, Jose A ^a   Le Poole, I Caroline ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Autoimmunity; HSP70; Knockout mouse; Vitiligo

Indexed keywords

HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DEPIGMENTATION; HAIR FOLLICLE; IMMUNE RESPONSE; IMMUNOGENICITY; IN VIVO STUDY; KNOCKOUT MOUSE; MELANOCYTE; MOUSE; NONHUMAN; PHENOTYPE; T LYMPHOCYTE ACTIVATION; VACCINATION; VITILIGO;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; DENDRITIC CELLS; FEMALE; GP100 MELANOMA ANTIGEN; HSP72 HEAT-SHOCK PROTEINS; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MELANOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OXIDOREDUCTASES; SKIN PIGMENTATION; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VITILIGO;

ANIMALIA; MUS;

EID: 83955161173     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2011.00916.x     Document Type: Article

References (40)

1. Asea, A. (2007). Mechanisms of HSP72 release. J. Biosci. 32, 579-584.
2. Asea, A., Kraeft, S.K., Kurt-Jones, E.A., Stevenson, M.A., Chen, L.B., Finberg, R.W., Koo, G.C., and Calderwood, S.K. (2000). HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat. Med. 6, 435-442.
3. Asea, A., Rehli, M., Kabingu, E., Boch, J.A., Bare, O., Auron, P.E., Stevenson, M.A., and Calderwood, S.K. (2002). Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 277, 15028-15034.
4. Avogadri, F., Merghoub, T., Maughan, M.F., Hirschhorn-Cymerman, D., Morris, J., Ritter, E., Olmsted, R., Houghton, A.N., and Wolchok, J.D. (2010). Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity. PLoS ONE 5, e12670.
5. Badri, A.M., Todd, P.M., Garioch, J.J., Gudgeon, J.E., Stewart, D.G., and Goudie, R.B. (1993). An immunohistological study of cutaneous lymphocytes in vitiligo. J. Pathol. 170, 149-155.
6. Basu, S., Binder, R.J., Suto, R., Anderson, K.M., and Srivastava, P.K. (2000). Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int. Immunol. 12, 1539-1546.
7. Boissy, R.E., and Manga, P. (2004). On the etiology of contact/occupational vitiligo. Pigment Cell Res. 17, 208-214.
8. Boudreau, J., Koshy, S., Cummings, D., and Wan, Y. (2008). Culture of myeloid dendritic cells from bone marrow precursors. J. Vis. Exp. pii 769. Doi:.
9. Cedercreutz, K., Denman, C.J., Klarquist, J., Vaitla, R., Boissy, R.E., Westerhof, W., Hernandez, C., and Le Poole, I.C. (2010). Vitiligo etiology and treatment: parameters derived from a patient survey. J. Dermatol. Nurs. Assoc. 2, 265-272.
10. Chapman, P.B., and Wolchok, J.D. (2002). Melanoma antigens: vaccines and monoclonal antibodies. In Melanoma: Biologically Targeted Therapeutics, E.C., Borden, ed. (Totowa, NJ: Humana Press Inc.), pp. 157-183.
11. Chen, T., Guo, J., Han, C., Yang, M., and Cao, X. (2009). Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway. J. Immunol. 182, 1449-1459.
12. Daugaard, M., Rohde, M., and Jaattela, M. (2007). The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions. FEBS Lett. 581, 3702-3710.
13. Denman, C.J., McCracken, J., Hariharan, V., Klarquist, J., Oyarbide-Valencia, K., Guevara- Patino, J.A., and Le Poole, I.C. (2008). HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. J. Invest. Dermatol. 128, 2041-2048.
14. Denning, T.L., Wang, Y.C., Patel, S.R., Williams, I.R., and Pulendran, B. (2007). Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 8, 1086-1094.
15. Eddy, E.M. (1998). HSP70-2 heat-shock protein of mouse spermatogenic cells. J. Exp. Zool. 282, 261-271.
16. Gregg, R.K., Nichols, L., Chen, Y., Lu, B., and Engelhard, V.H. (2010). Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J. Immunol. 184, 1909-1917.
17. Guevara-Patino, J.A., Engelhorn, M.E., Turk, M.J., Liu, C., Duan, F., Rizzuto, G., Cohen, A.D., Merghoub, T., Wolchok, J.D., and Houghton, A.N. (2006). Optimization of a self antigen for presentation of multiple epitopes in cancer immunity. J. Clin. Invest. 116, 1382-1390.
18. Han, J.M., Kwon, N.H., Lee, J.Y., Jeong, S.J., Jung, H.J., Kim, H.R., Li, Z., and Kim, S. (2010). Identification of gp96 as a novel target for treatment of autoimmune disease in mice. PLoS ONE 5, e9792.
19. Hu, Y., Shen, F., Crellin, N.K., and Ouyang, W. (2011). The IL-17 pathway as a major therapeutic target in autoimmune diseases. Ann. N. Y. Acad. Sci. 1217, 60-76.
20. Hunt, C.R., Dix, D.J., Sharma, G.G., Pandita, R.K., Gupta, A., Funk, M., and Pandita, T.K. (2004). Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol. Cell. Biol. 24, 899-911.
21. Jin, Y., Birlea, S. A., Fain, P. R. et al. (2010). Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N. Engl. J. Med. 362, 1686-1697.
22. Kabani, M., and Martineau, C.N. (2008). Multiple Hsp70 isoforms in the eukaryotic cytosol: mere redundancy or functional specificity?. Curr. Genomics 9, 338-348.
23. Kuppner, M.C., Gastpar, R., Gelwer, S., Nossner, E., Ochmann, O., Scharner, A., and Issels, R.D. (2001). The role of heat shock protein (hsp70) in dendritic cell maturation: Hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors. Eur. J. Immunol. 31, 1602-1609.
24. Lane, C., Leitch, J., Tan, X., Hadjati, J., Bramson, J.L., and Wan, Y. (2004). Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin. Cancer Res. 64, 1509-1514.
25. Le Poole, I.C., and Luiten, R.M. (2008). Autoimmune etiology of generalized vitiligo. Curr. Dir. Autoimmun. 10, 227-243.
26. Le Poole, I.C., van den Wijngaard, R.M., Westerhof, W., Dutrieux, R.P., and Das, P.K. (1993). Presence or absence of melanocytes in vitiligo lesions: an immunohistochemical investigation. J. Invest. Dermatol. 100, 816-822.
27. Li, Z., Dai, J., Zheng, H., Liu, B., and Caudill, M. (2002). An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. Front. Biosci. 7, 731-751.
28. Millar, D.G., and Ohashi, P.S. (2007). Hsp70 family members, danger signals and autoimmunity. In Heat Shock Proteins: Potent Mediators of Inflammation and Immunity, A.A.A., Asea and A., De Maio, eds. (Dordrecht: Springer), pp. 189-211.
29. Millar, D.G., Garza, K.M., Odermatt, B., Elford, A.R., Ono, N., Li, Z., and Ohashi, P.S. (2003). Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat. Med. 9, 1469-1476.
30. Millington, G.W., and Levell, N.J. (2007). Vitiligo: the historical curse of depigmentation. Int. J. Dermatol. 46, 990-995.
31. Multhoff, G. (2006). Heat shock proteins in immunity. Handb. Exp. Pharmacol. 172, 279-304.
32. Muranski, P. et al. (2008). Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112, 362-373.
33. Murshid, A., Gong, J., and Calderwood, S.K. (2008). Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation. Expert Rev. Vaccines 7, 1019-1030.
34. Ongenae, K., Van Geel, N., and Naeyaert, J.M. (2003). Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res. 16, 90-100.
35. Overwijk, W.W. et al. (2003). Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J. Exp. Med. 198, 569-580.
36. Sanchez-Perez, L., Kottke, T., Daniels, G.A., Diaz, R.M., Thompson, J., Pulido, J., Melcher, A., and Vile, R.G. (2006). Killing of normal melanocytes, combined with heat shock protein 70 and CD40L expression, cures large established melanomas. J. Immunol. 177, 4168-4177.
37. Snoek, M., Jansen, M., Olavesen, M.G., Campbell, R.D., Teuscher, C., and van Vugt, H. (1993). Three Hsp70 genes are located in the C4-H-2D region: possible candidates for the orch-1 locus. Genomics 15, 350-356.
38. Srivastava, P. (2002). Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20, 395-425.
39. Strbo, N., and Podack, E.R. (2008). Secreted heat shock protein gp96-ig: an innovative vaccine approach. Am. J. Reprod. Immunol. 59, 407-416.
40. Tosti, G., di Pietro, A., Ferrucci, P.F., and Testori, A. (2009). HSPPC-96 vaccine in metastatic melanoma patients: from the state of the art to a possible future. Expert Rev. Vaccines 8, 1513-1526.