Modes of degradation and impurity characterization in rhPTH (1-34) during stability studies

PDA Journal of Pharmaceutical Science and Technology

Volumn 65, Issue 4, 2011, Pages 348-362

  Kothari, Ruchi ^a   Kumar, Vinod ^a   Jena, Rajender ^a   Tunga, Rashbehari ^a   Tunga, Binita Shrivastava ^a  

^a Intas Biopharmaceuticals Ltd   (Switzerland)

Author keywords

Deamidation; LCMS; N terminal sequencing; Oxidation; Peptide; Peptide bond cleavage; RP HPLC; Tricine SDS PAGE

Indexed keywords

ASPARAGINE; CYANOGEN BROMIDE; RECOMBINANT PARATHYROID HORMONE; SUCCINIMIDE; AMINO ACID; METHIONINE;

AMINO ACID SEQUENCE; ARTICLE; DEAMINATION; DRUG DEGRADATION; DRUG IMPURITY; DRUG STABILITY; DRUG STORAGE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SHELF LIFE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; MOLECULAR WEIGHT;

AMINO ACID SEQUENCE; AMINO ACIDS; ASPARAGINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; MASS SPECTROMETRY; METHIONINE; MOLECULAR WEIGHT;

EID: 83755196135     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: 10.5731/pdajpst.2011.00745     Document Type: Article

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