A model of mouse motor nerve excitability and the effects of polarizing currents

Journal of the Peripheral Nervous System

Volumn 16, Issue 4, 2011, Pages 322-333

  Boërio, Delphine ^a   Greensmith, Linda ^a   Bostock, Hugh ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

membrane potential; mice; modeling; nerve excitability; polarizing currents

Indexed keywords

POTASSIUM;

ANIMAL EXPERIMENT; ARTICLE; ELECTRODE; FEMALE; MOTOR ACTIVITY; MOUSE; NERVE CONDUCTION; NERVE EXCITABILITY; NERVE FIBER; NERVE FIBER MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; TAIL;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; ELECTRIC STIMULATION; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MODELS, NEUROLOGICAL; MOTOR NEURONS; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 83755196096     PISSN: 10859489     EISSN: 15298027     Source Type: Journal    
DOI: 10.1111/j.1529-8027.2011.00364.x     Document Type: Article

References (31)

1. Baker M, Bostock H, (1989). Depolarization changes accommodation in rat and human motor axons. J Physiol 411: 545-561. (Pubitemid 19104552)
2. Barrett EF, Barrett JN, (1982). Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential. J Physiol 323: 117-144. (Pubitemid 12180900)
3. Boërio D, Greensmith L, Bostock H, (2009). Excitability properties of motor axons in the maturing mouse. J Peripher Nerv Syst 14: 45-53.
4. Boërio D, Kalmar B, Greensmith L, Bostock H, (2010). Excitability properties of mouse motor axons in the mutant SOD1(G93A) model of amyotrophic lateral sclerosis. Muscle Nerve 41: 774-784.
5. Bostock H, (1995). Mechanisms of accommodation and adaptation in myelinated axons. In: The Axon., Waxman SG, Kocsis JD, Stys PK, (Eds). Oxford University Press, New York, pp 311-327.
6. Bostock H, (2006). A computer program to aid interpretation of multiple excitability measurements on human motor axons. Clin Neurophysiol 117: S85.
7. Bostock H, Baker M, Reid G, (1991). Changes in excitability of human motor axons underlying post-ischaemic fasciculations: evidence for two stable states. J Physiol 441: 537-557.
8. Bostock H, Burke D, Hales JP, (1994). Differences in behavior of sensory and motor axons following release of ischaemia. Brain 117: 225-234. (Pubitemid 24155495)
9. Bostock H, Cikurel K, Burke D, (1998). Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 21: 137-158. (Pubitemid 28079733)
10. Brau ME, Sander F, Vogel W, Hempelmann G, (1997). Blocking mechanisms of ketamine and its enantiomers in enzymatically demyelinated peripheral nerve as revealed by single-channel experiments. Anesthesiology 86: 394-404. (Pubitemid 27093383)
11. Burke D, Kiernan MC, Bostock H, (2001). Excitability of human axons. Clin Neurophysiol 112: 1575-1585. (Pubitemid 32763239)
12. George A, Bostock H, (2007). Multiple measures of axonal excitability in peripheral sensory nerves: an in vivo rat model. Muscle Nerve 36: 628-636. (Pubitemid 47623850)
13. Herold KF, Nau C, Ouyang W, Hemmings HC Jr, (2009). Isoflurane inhibits the tetrodotoxin-resistant voltagegated sodium channel Nav1.8. Anesthesiology 111: 591-599.
14. Jankelowitz SK, Howells J, Burke D, (2007). Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjects. J Physiol 581: 927-940. (Pubitemid 46887972)
15. Kiernan MC, Bostock H, (2000). Effects of membrane polarization and ischaemia on the excitability properties of human motor axons. Brain 123: 2542-2551.
16. Kiernan MC, Burke D, Andersen KV, Bostock H, (2000). Multiple measures of axonal excitability: a new approach in clinical testing. Muscle Nerve 23: 399-409. (Pubitemid 30126986)
17. Kiernan MC, Guglielmi JM, Kaji R, Murray NM, Bostock H, (2002). Evidence for axonal membrane hyperpolarization in multifocal motor neuropathy with conduction block. Brain 125: 664-675. (Pubitemid 34194419)
18. Kiernan MC, Isbister GK, Lin CS, Burke D, Bostock H, (2005). Acute tetrodotoxin-induced neurotoxicity after ingestion of puffer fish. Ann Neurol 57: 339-348. (Pubitemid 40343955)
19. Krarup C, Moldovan M, (2009). Nerve conduction and excitability studies in peripheral nerve disorders. Curr Opin Neurol 22: 460-466.
20. Krishnan AV, Lin CS, Park SB, Kiernan MC, (2008a). Assessment of nerve excitability in toxic and metabolic neuropathies. J Peripher Nerv Syst 13: 7-26. (Pubitemid 351393017)
21. Krishnan AV, Bostock H, Ip J, Hayes M, Watson S, Kiernan MC, (2008b). Axonal function in a family with episodic ataxia type 2 due to a novel mutation. J Neurol 255: 750-755.
22. Krishnan AV, Lin CS, Park SB, Kiernan MC, (2009). Axonal ion channels from bench to bedside: a translational neuroscience perspective. Prog Neurobiol 89: 288-313.
23. Lin S-Y, Krishnan AV, Lee M-J, Zagami AS, You H-L, Yang C-C, Bostock H, Kiernan MC, (2008). Nerve function and dysfunction in acute intermittent porphyria. Brain 131: 2510-2519.
24. Moldovan M, Krarup C, (2006). Evaluation of Na+/K+ pump function following repetitive activity in mouse peripheral nerve. J Neurosci Methods 155: 161-171. (Pubitemid 44232999)
25. Moldovan M, Alvarez S, Krarup C, (2009). Motor axon excitability during Wallerian degeneration. Brain 132: 511-523.
26. Nodera H, Kaji R, (2006). Nerve excitability testing and its clinical application to neuromuscular diseases. Clin Neurophysiol 117: 1902-1916. (Pubitemid 44247879)
27. Sawai S, Kanai K, Nakata M, Hiraga A, Misawa S, Isose S, Hattori T, Kuwabara S, (2008). Changes in excitability properties associated with axonal regeneration in human neuropathy and mouse Wallerian degeneration. Clin Neurophysiol 119: 1097-1105.
28. Shiraishi M, Harris RA, (2004). Effects of alcohols and anesthetics on recombinant voltage-gated Na+ channels. J Pharmacol Exp Ther 309: 987-994. (Pubitemid 38669684)
29. Susuki K, Baba H, Tohyama K, Kanai K, Kuwabara S, Hirata K, Furukawa K, Furukawa K, Rasband MN, Yuki N, (2007). Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers. Glia 55: 746-757. (Pubitemid 46663027)
30. Tomlinson SE, Tan SV, Kullmann DM, Griggs RC, Hanna MG, Burke D, Bostock H, (2010). Nerve excitability studies characterize Kv1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1. Brain 133: 3530-3540.
31. Yang Q, Kaji R, Hirota N, Kojima Y, Takagi T, Kohara N, Kimura J, Shibasaki H, Bostock H, (2000). Effect of maturation on nerve excitability in an experimental model of threshold electrotonus. Muscle Nerve 23: 498-506. (Pubitemid 30164774)