A case of myeloma with hypercalcemia caused by high serum concentrations of both parathyroid hormone-related peptide (PTHrp) and macrophage inflammatory protein-1α (MIP-1α)

Internal Medicine

Volumn 50, Issue 24, 2011, Pages 2993-2996

  Shimizu, Hiroaki ^a   Monden, Tsuyoshi ^a   Tomotsune, Takanori ^a   Nakatani, Yuki ^a   Domeki, Nozomi ^a   Matsumura, Mihoko ^b   Jojima, Teruo ^a   Kawagoe, Yoshiaki ^a   Kasai, Kikuo ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b Tochigi Medical Association Shiobara Onsen Hospital   (Japan)

Author keywords

Humoral hypercalcemia of malignancy; Local osteolytic hypercalcemia; Macrophage inflammatory protein 1 ; Parathyroid hormone related peptide

Indexed keywords

BENCE JONES PROTEIN; CALCITONIN; DEXAMETHASONE; DOXORUBICIN; FUROSEMIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PAMIDRONIC ACID; PARATHYROID HORMONE RELATED PROTEIN; VINCRISTINE SULFATE;

ADULT; ARTICLE; BACKACHE; BONE DENSITOMETRY; BONE MARROW EXAMINATION; BONE SCINTISCANNING; CALCIUM BLOOD LEVEL; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; HYPERCALCEMIA; IMMUNOELECTROPHORESIS; LABORATORY TEST; METASTASIS; MULTIPLE MYELOMA; MYELOMA; NEEDLE BIOPSY; PROTEIN BLOOD LEVEL; XEROSTOMIA;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE DENSITY CONSERVATION AGENTS; CALCITONIN; CALCIUM; CHEMOKINE CCL3; DEXAMETHASONE; DIPHOSPHONATES; DOXORUBICIN; FEMALE; HUMANS; HYPERCALCEMIA; MIDDLE AGED; MULTIPLE MYELOMA; PARATHYROID HORMONE-RELATED PROTEIN; VINCRISTINE;

EID: 83755173665     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.50.6096     Document Type: Article

References (12)

1. Rosol TJ, Capen CC. Biology of disease. Mechanisms of cancerinduced hypercalcemia. Lab Invest 67: 680-702, 1992.
2. Burt ME, Brennan MF. Incidence of hypercalcemia and malignant neoplasm. Arch Surg 115: 704-707, 1980.
3. Suva LJ, Winslow GA, Wettenhall RE, et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 237: 893-896, 1987.
4. Strewler GJ, Stern PH, Jacobs JW, et al. Parathyroid hormone-like protein from human renal carcinoma cells. J Clin Invest 80: 1803-1807, 1987.
5. Shionoiri A, Horiuchi T, Onouchi T, et al. Hypercalcemia induced with the plasma levels of parathyroid hormone-related peptide in multiple myeloma. Internal Medicine 39: 810-813, 2000.
6. Kitazawa R, Kitazawa S, Kajimoto K, et al. Expression of parathyroid hormone-related protein (PTHrP) in multiple myeloma. Pathol Int 52: 63-68, 2002.
7. Zeimer H, Firkin F, Grill V, Slavin J, Zhou H, Martin TJ. Assessment of cellular expression of parathyroid hormone-related protein mRNA and protein in multiple myeloma. J Pathol 192: 336-341, 2000.
8. Gao JL, Kuhns DB, Tiffany HL, et al. Structure and functional expression of the human macrophage inflammatory protein 1α/RANTES receptor. J Exp Med 177: 1421-1427, 1993.
9. Abe M, Hiura K, Javier W, et al. Role for macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta in the development of osteolytic lesions in multiple myeloma. Blood 100: 2195-2202, 2002.
10. Hashimoto T, Abe M, Oshima T, et al. Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1α and MIP-1β correlates with lytic bone lesions in patients with multiple myeloma. Brit J Hematol 125: 38-41, 2004.
11. Jaffe JP, Mosher DF. Calcium binding by a myeloma protein. Am J Med 67: 343-346, 1979.
12. Merlini G, Fitzpatrick LA, Siris ES, et al. A human myeloma immunoglobulin G binding four moles of calcium associated with asymptomatic hypercalcemia. J Clin Immunol 4: 185-196, 1984.