Ascorbic acid: What do we really NO?

Journal of Applied Physiology

Volumn 111, Issue 6, 2011, Pages 1542-1543

  Holowatz, Lacy A ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b 113 Noll Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASCORBIC ACID; NITRIC OXIDE;

BODY TEMPERATURE; CHRONIC KIDNEY FAILURE; DRUG EFFECT; EDITORIAL; FEMALE; HEAT INJURY; HUMAN; INNERVATION; MALE; METABOLISM; MICROCIRCULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; SKIN; VASCULARIZATION; VASODILATATION;

ARGININE; ASCORBIC ACID; BODY TEMPERATURE; DIABETES MELLITUS, TYPE 2; FEMALE; HEAT STRESS DISORDERS; HUMANS; MALE; MICROCIRCULATION; NITRIC OXIDE; RENAL INSUFFICIENCY, CHRONIC; SKIN; VASODILATION;

EID: 83655191535     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01187.2011     Document Type: Editorial

References (10)

1. Dupont JJ, Farquhar WB, Townsend RR, Edwards DG. Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease. J Appl Physioldoi:10.1152/japplphysiol.00419.2011.
2. Holowatz LA, Santhanam L, Webb A, Berkowitz DE, Kenney WL. Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans. J Physiol 589: 2093-2103, 2011.
3. Holowatz LA, Thompson CS, Kenney WL. L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. J Physiol 574: 573-581, 2006.
4. Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol 91: 1619-1626, 2001. (Pubitemid 32900352)
5. Santhanam L, Lim HK, Lim HK, Miriel V, Brown T, Patel M, Balanson S, Ryoo S, Anderson M, Irani K, Khanday F, Di Costanzo L, Nyhan D, Hare JM, Christianson DW, Rivers R, Shoukas A, Berkowitz DE. Inducible NO synthase dependent S-nitrosylation and activation of arginase 1 contribute to age-related endothelial dysfunction. Circ Res 101: 692-702, 2007. (Pubitemid 47494100)
6. Smith CJ, Santhanam L, Bruning RS, Stanhewicz A, Berkowitz DE, Holowatz LA. Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension; doi:10.1161/HYPERTENSIONAHA.111.178129. (19 September 2011). Epub ahead of print.
7. Sokolnicki LA, Strom NA, Roberts SK, Kingsley-Berg SA, Basu A, Charkoudian N. Skin blood flow and nitric oxide during body heating in type 2 diabetes mellitus. J Appl Physiol 106: 566-570, 2009.
8. Stewart JM, Medow MS, Minson CT, Taneja I. Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 293: H2161-H2167, 2007. (Pubitemid 47605858)
9. Sydow K, Munzel T. ADMA and oxidative stress. Atheroscler Suppl 4: 41-51, 2003. (Pubitemid 38234494)
10. Toth M, Kukor Z, Valent S. Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity. Mol Hum Reprod 8: 271-280, 2002. (Pubitemid 34196354)