Dietary supplementation with an extract of North American ginseng in adult and juvenile mice increases natural killer cells

Immunological Investigations

Volumn 41, Issue 2, 2012, Pages 157-170

  Miller, Sandra C ^a   Ti, Lianping ^a   Shan, Jacqueline ^b  

^a MCGILL UNIVERSITY   (Canada)

^b Afexa Life Sciences Inc   (Canada)

Author keywords

Adult; Ginseng; Immunity; Juvenile; NK cells

Indexed keywords

CVT E002; GINSENG EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BONE MARROW; CELL COUNT; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; GINSENG; GROUPS BY AGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN;

ANIMALS; ANIMALS, NEWBORN; BONE MARROW CELLS; DIETARY SUPPLEMENTS; IMMUNITY, INNATE; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; MICE; MICE, INBRED C3H; PANAX; PLANT EXTRACTS;

EID: 83655191264     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820139.2011.599087     Document Type: Article

References (41)

1. Ames, I. H., Gates, C. E., Garcia, A. M., John, P. A., Hennig, A. K., Tomar, R. H. (1987). Lysis of fresh murine mammary tumor cells by syngeneic natural killer cells and lymphokine-activated killer cells. Cancer Immunol. Immunother. 25:161-168.
2. Ames, I. H., Gagne, G. M., Garcia, A. M., John, P. A., Scatorchia, G. M., Tomar, R. H., McAfee, J. G. (1989). Preferential homing of tumor-infiltrating lymphocytes in tumor-bearing mice. Cancer Immunol. Immunother. 29:93-100. (Pubitemid 19134749)
3. Andrades, J. A., Han, B., Becerra, J. Sorgente, N., Hall, F. L., Nimni, M. E. (1999). A recombinant human TGF-beta 1 fusion protein with collagen-binding domain promotes migration, growth and differentiation of bone marrowmesenchymal cells. Exp. Cell Res. 250:485-498. (Pubitemid 29367459)
4. Argyris, B. F. (1981). Suppressor factor produced by neonatal mouse spleen cells. Cell. Immunol. 62:412-424. (Pubitemid 11049244)
5. Babcock, G. F., Phillips, J. H. (1983). Human NK cells: Light and electron microscopic characteristics. Immunol. Res. 2(1): 88-101. (Pubitemid 13085530)
6. Bianco, P., Riminucci, M., Kuznetsov, S., Robey, P. G. (1999). Multipotential cells I the bone marrow stroma: regulation in the context of organ physiology. Crit. Rev. Eukaryot. Gene Expr. 9:159-173.
7. Bianco, P., Robey, P. G. (2000). Marrow stromal stem cells. J. Clin. Invest. 105(12): 1663-1668. (Pubitemid 30421745)
8. Dussault, I., Miller, S. C. (1993). Stimulation of natural killer cell numbers but not function in leukemic infant mice: A system primed in infancy allows survival in adulthood. Nat. Immun. 12:66-78. (Pubitemid 23161051)
9. Facco, M., Zilli, C., Siviero, M., Ermolao, A., Travain, G., Baesso, I., Bonamico, S., Cabrelle, A., Marco, Z., Agostini, C. (2005). Modulation of immune response by the acute and chronic exposure to high altitude. Med. Sci. Sports Exer. 37(5):768-774. (Pubitemid 40628281)
10. Fong, C., Brodeur, G. M. (1987) Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Gen. Cytogen. 28(1): 55-76. (Pubitemid 17153555)
11. Gronthos, S., Simmons, P. J. (1995). The growth factor requirements of STROM-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood 85:929-940.
12. Haller, O., Wigzell, H. (1977) Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent. J. Immunol. 118:1503-1506. (Pubitemid 8095893)
13. Herberman, R. B., Nunn, M. E., Larvin, D. H. (1975). Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivilty and specificity. Int. J. Cancer 16:216-229.
14. Kalland, T. (1986). Generation of natural killer cells from bone marrow precursors in vitro. Immunology 57:493-498. (Pubitemid 16111216)
15. Keever, C. A., Pekle, K., Gazzola, M. V., Collins, N. H., Gillio, A.(1990). NK and LAK activities from human marrow progenitors. I. The effects of interleukin-2 and interleukin-1. Cell. Immunol. 126:211-226. (Pubitemid 20088597)
16. Keissling, R., Wigzell, H. (1979) An analysis of the murine NK cells as to structure, function and biological relevance. Immunol. Rev. 44:165-208. (Pubitemid 9166059)
17. Koo, G. C.,Manyak, C. L. (1986). Generation of cytotoxic cells from murine bone marrow by human recombinant IL2. J. Immunol. 137:1751-1756. (Pubitemid 16021078)
18. Kuznetsov, S. A., Friedenstein, A. J., Robey, P. G. (1997). Factors required for bone marrow stromal fibroblast colony formation in vitro. Br. J. Haematol. 97:561-570. (Pubitemid 27261620)
19. Ortaldo, J. R., Herberman, R. B. (1984). Heterogeneity of natural killer cells. Ann. Rev. Immunol. 2: 359-394.
20. Maier, T., Holda, J. H., Claman, H. N. (1989). Murine natural suppressor cells in the newborn, in the bone marrow after cyclophosphamide. Genetic variations and dependence on IFN-gamma. J. Immunol. 143:491-498. (Pubitemid 19191542)
21. Maloney, M. X., Currier, N. L., Miller, S. C. (1998). Natural killer cell levels in older adult mice are gender-dependent: Thyroxin is a gender-independent natural killer cell stimulant. Nat. Immun. 16:165-174. (Pubitemid 29271727)
22. Miller, S. C. (1982). Production and renewal of murine natural killer cells in the spleen and bone marrow. J. Immunol. 129(5):2282-2286. (Pubitemid 12004410)
23. Miller, S. C., Delorme, D. (2008). An extract from North American ginseng stimulates spontaneous immunity in infant mice: sustained, augmented immunity in adulthood long after withdrawal of the extract. J. Com. Integ. Med. 5(1): http://www.bepress.com/jcim/vol5/iss1/6
24. Miller, S. C., Delorme, D., Shan, J. J. (2009). CVT-E002 stimulates the immune system and extends the life span of mice bearing a tumor of viral origin. J. Soc. Integ. Oncol. 7(4):127-136.
25. Miller, S. C., Delorme, D., Shan, J.J. (2010). A proprietary extract of North American ginseng (Panax Quinquefolius), administered to leukemic, juvenile mice extends their life span in a dose-dependent manner. J. Com. Integ. Med. http://www.bepress.com/jcim/vol8/iss1/10
26. Miller, S. C., Kearney, S. L. (1997). Effect of in vitro administration of trans retinoic on the hemopoietic cell populations of spleen and bone marrow: Profound strain differences between A/J and C57Bl/6J mice. Lab. Anim. Sci. 48(1):74-80. (Pubitemid 128521102)
27. Pollack, S. B., Rosse, C. (1987). The primary role of murine bone marrow in the production of natural killer cells: A cytokinetic study. J. Immunol. 139: 2149-2156. (Pubitemid 17152106)
28. Riccardi, C., Barlozzari, T., Santoni, A., Herberman, R.B. (1981). Transfer to cyclophosphamide-treated mice of natural killer (NK) cells and in vivo natural reactivity against tumors. J. Immunol. 126:1284-1289. (Pubitemid 11149211)
29. Rosmaraki, E.E., Douagi, I., Roth, C., Colucci, F., Clumano, A., DiSanto, J.P.(2001). Identification of committed NK cell progenitors in adult murine bone marrow. Eur. J. Immunol. 31(6): 1900-1909. (Pubitemid 32547352)
30. Ross, J. A., Spector, L. G., Robinson, L. L., Olshan, A. F. (2005) Epidemiology of leukemia in children with Down's Syndrome. Ped. Blood Cancer 44:8-12. (Pubitemid 39602559)
31. Satomura, K., Derubeis, A. R., Fedarko, N. S. (1998). Receptor tyrosine kinase expression in human bone marrow stromal cells. J. Cell. Physiol. 177:426-328.
32. Seaman, W. E., Blackman, M. A.,Gindhart, T. D., Roubinian, J. R., Loeb, J. M., Talal,N. (1978). Estradiol reduces natural killer cells in mice. J. Immunol. 121:2193 (abst.).
33. Sensebé, L., Mortensen, B. T., Fixe, P., Hervé, P., Charbord, P. (1997). Cytokines active on granulomonopoiesis: release and consumption by human marrow myeloid stromal cells. Br. J. Haematol. 98:274-282. (Pubitemid 27345096)
34. Shan, J. J., Rodgers, K., Lai, C.-T., Sutherland, S. K. (2007). Challenges in natural health product research: The importance of standardization. Proc. West. Pharmacol. Soc. 50:24-30.
35. Sun, L. Z.-Y., Currier, N. L., Miller, S. C. (1999). The American coneflower: A prophylactic role involving non-specific immunity. J. Alt. Comp. Med. 5(5):437-446. (Pubitemid 29489699)
36. Timonen, T., Saksela, E. (1980). Isolation of human natural killer cells by density gradient centrifugation. J. Immunol. Meth. 36:285-291. (Pubitemid 10054061)
37. Van den Brink, M. R. M., Boggs, S. S., Herberman, R. B. (1990). The generation of natural killer (NK) cells from NK precursor cells in rat long-term bone marrow cultures. J. Exp. Med. 172:303-313. (Pubitemid 20217272)
38. Vecchini, F., Delfino, D., Patrene, K. D., DeLeo, A., Lu, L., Herberman, R. B., Boggs, S. S. (1993). Generation of natural killer cells from long-term cultures of mouse bone marrow. Nat. Immun. 12:1-16. (Pubitemid 23079735)
39. Wang, M., Guilbert, L. J., Ling, L., Li, J., Wu, Y., Xu, S., Pang, P., Shan, J. J. (2001). Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolius). J. Pharm. Pharmacol. 22:1515-1523. (Pubitemid 33064541)
40. Wang,M., Guilbert, L. J., Li, J.,Wu, Y., Pang, P., Basu, T. K., Shan, J. J. (2004). A proprietary extract from North American ginseng (Panax quinquefolius) enhances IL-2 and IFN-ã production in murine spleen cells induced by Con-A. Int. Immunopharm. 4:311-315. (Pubitemid 38296359)
41. Yan, Z.-J.,Wang, Q.-R., McNeice, I. K.,Wolfe, N. S. (1990). Dissecting the hematopoietic microenvironment. VII. The production of an autostimulatory factor as well as a CSF by unstimulated murine marrow fibroblasts. Exp. Hematol. 18:348-354. (Pubitemid 20170899)