An extract from north American ginseng stimulates spontaneous immunity in infant mice: Sustained, augmented immunity in adulthood long after withdrawal of the extract

Journal of Complementary and Integrative Medicine

Volumn 5, Issue 1, 2008, Pages

  Miller, Sandra C ^a   Delorme, Danielle ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

CVT E002; Immunity; Infant mice; NK cells

Indexed keywords

CVT E002; GINSENG EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; GRANULOCYTE; HEMATOPOIETIC CELL; HOST RESISTANCE; IMMUNITY; IMMUNOCOMPETENT CELL; LEUKEMIA; LYMPHOMA; MOUSE; NATURAL KILLER CELL; NEPHROBLASTOMA; NEWBORN; NONHUMAN; RETINOBLASTOMA; TUMOR IMMUNITY;

EID: 44649116006     PISSN: 15533840     EISSN: None     Source Type: Journal    
DOI: 10.2202/1553-3840.1117     Document Type: Article

References (60)

1. Mosier, D.E. and B.M. Johnson. Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes. J Exp Med. 1975;141: 216-226.
2. Spear, P.G. and G. Edelman. Maturation of the humoral immune response in mice. J Exp Med. 1974;139:249-263.
3. Sherwin, W.K. and D.T. Rowlands. Determinants of the hierarchy of humoral immune responsiveness during ontogeny. J Immunol. 1975;115:1549-1554.
4. Spear, P.G., A.L. Wang, U. Rutishauser, et al. Characteristics of splenic lymphoid cells in fetal and newborn mice. J Exp Med. 1973;138:557-573.
5. Velardi, A. and M.D. Cooper. An immunofluorescence analysis of the ontogeny of myeloid, T, and B lineage cells in the mouse hemopoietic tissues. J Immunol. 1984;133:672-677.
6. Holan, V., M. Lipoldova and A. Zajicova. Immunolgical nonreactivity of newborn mice: Immaturity of T cells and selective action of neonatal suppressor cells. Cell Immunol. 1991;137:216-223.
7. Chiscon, M.Q. and E.S. Golub. Functional development of the interacting cells of the immune response. I. Development of T cell and B cell function. J Immunol 1972;108:1379-1386.
8. Klinman, N.R. The acquisition of B cell competence and diversity. Am J Pathol. 1976;85:693-703.
9. Argyris, B.F. Role of macrophages in immunological maturation. J Exp Med. 1968; 128:459-467.
10. Landahl, C.A. Ontogeny of adherent cells. I. Distribution and ontogeny of cells participating in the response to sheep erythrocytes in vitro. Eur J Immunol 1976;6:130-134.
11. Strober, S. Natural suppressor (NS) cells, neonatal tolerance and total lymphoid irradiation: exploring obscure relationships. Ann Rev Immunol 1984;2:219-237.
12. Argyris, B.F. Suppressor activity in the spleen of neonatal mice. Cell Immunol. 1978;36:354-362.
13. Maier, T., J.H. Holda and H.N. Claman. Murine natural suppressor cells in the newborn, in the bone marrow and after cyclophosphamide. Genetic variations and dependence on IFN-gamma. J Immunol. 1989;143:491-498.
14. Calkins, C.E. and O. Stutman. Changes in suppressor mechanisms during post-natal development in mice. J Exp Med. 1978;147:87-97.
15. Hertell-Wulff, B. and S. Strober. Immunosuppressive lymphokines derived from natural suppressor cells. J Immunol. 1988;240:2633-2638.
16. Argyris, B.F. Suppressor factor produced by neonatal mouse spleen cells. Cell Immunol 1981;62:412-424.
17. Keissling, R., E. Klein, H. Pross et al. Natural killer cells in the mouse. II Cytotoxic cells with specificity for mouse Maloney leukemia cells. Characteristics of the killer cell. Eur J Immunol. 1975;5:117-121.
18. Biron, C.A. and R.M. Welsh. Activation and role of natural killer cells in virus infections. Med Microbiol Immunol (Berl). 1982;170:155-172.
19. "and". Blastogenesis of natural killer cells during viral infection in vivo. J Immunol 1982;129:2788-2795.
20. Herberman, R.B., M.E. Nunn, and D.H. Larvin. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity. Int J Cancer 1975;16:216-229.
21. Riccardi, C., T. Barlozzari, A. Santoni et al. Transfer to cyclophosphamide-treated mice of natural killer (NK) cells and in vivo natural reactivity against tumors. J Immunol 1981;126:1284-1289.
22. Lala, P.K., V. Santar, H. Libenson et al. Changes in host natural killer regulation in mice during tumor development. I. Kinetic and in vivo significance. Cell Immunol. 1985;93:250-264.
23. Miller, S.C., M.T. Gallagher, S.K. Datta et al. Development of natural killer cell activity and genetic resistance to bone marrow transplantation with age: Effect of neonatal thymectomy. Scand J Immunol 1981;13:105-110.
24. Dussault, I. and S.C. Miller. Suppression of natural killer cell activity in infant mice occurs after target cell binding. Nat Immun. 1995;14:35-43.
25. "and". Stimulation of natural killer cell numbers but not function in leukemic infant mice: A system primed in infancy allows survival in adulthood. Nat Immun. 1993;12:66-78.
26. Miller, S.C. Production and renewal of murine natural killer cells in the spleen and bone marrow. J Immunol. 1982; 129(5):2282-2286.
27. Miller, S.C. Life history of cells mediating natural resistance to tumor cells and bone marrow transplants: The respective roles of cell lineage commitment and host environment in determining strain characteristics of natural resistance to foreign marrow grafts. Am J Anat. 1984; 170:367-376.
28. Brousseau, M. and S.C. Miller. Enhancement of natural killer cells and increased survival of aging mice fed daily Echinacea root extract from youth. Biogerontology 2005;6:157-163.
29. Whyte, A.L. and S.C. Miller. Strain difference in natural killer cell-mediated immunity among mice: a possible mechanism for the low natural killer cell activity of A/J mice. Immunobiology 1998;199:23-38.
30. Miller, S.C. and S.L. Kearney. Effect of in vitro administration of trans retinoic acid on the hemopoietic cell populations of spleen and bone marrow: profound strain differences between A/J and C57Bl/6J mice. Lab An Sci. 1997;48(1):74-80.
31. Mahoney, M.X., N.L. Currier and S.C. Miller. Natural killer cell levels in older adult mice are gender-dependent: thyroxin is a gender-independent natural killer cell stimulant. Nat Immun. 1998;16:165-174.
32. Sun, L.Z-Y., N.L. Currier and S.C. Miller. The American Coneflower: A prophylactic role involving nonspecific immunity. J Alt Comp Med. 1999;5(5):437-446.
33. Koo, G.C. and C.L. Manyak. Generation of cytotoxic cells from murine bone marrow by human recombinant IL2. J Immunol. 1986;137:1751.
34. Keever, C.A., K. Pekle, M.V. Gazzola et al. NK and LAK activities from human marrow progenitors: I. The effects of interleukin-2 and interleukin-1. Cell Immunol. 1990;126:211-226.
35. Fuchshuber, P.R. and E. Lotzova. Feeder cells enhance oncoloytic and proliferative activity of long-term human bone marrow interleukin-2 cultures and induce different lymphocyte subsets. Cancer Immunol Immunother. 1991;33:15-20.
36. Vecchini, F., D. Delfino, K.D. Patrene et al. Generation of natural killer cells from long-term cultures of mouse bone marrow. Nat Immun. 1993;12:1-16.
37. Tsuji, J.M. and S.B. Pollack. Maturation of murine natural killer precursor cells in the absence of exogenous cytokines requires contact with bone marrow stroma. Nat Immun. 1995;14:44-56.
38. Pollack, S.B. and C. Rosse. The primary role of murine bone marrow in the production of natural killer cells: A cytokinetic study. J Immunol. 1987;139:2149-2156.
39. Kalland, T. Generation of natural killer cells from bone marrow precursors in vitro. Immunology 1986;57:493-498.
40. Van den Brink, M.R.M., S.S. Boggs, R.B. Herberman et al. The generation of natural killer (NK) cells from NK precursor cells in rat long-term bone marrow cultures. J Exp Med. 1990;172:303-313.
41. Rosmaraki, E.E., I. Douagi, C.Roth et al. Identification of committed NK cell progenitors in adult murine bone marrow. Eur J Immunol.2001;31(6):1900- 1909.
42. Colucci, F., M.A. Caligiuri and J.P. Di Santo. What does it take to make a natural killer? Nature Rev (Immunology) 2003;3:413-425.
43. Sensebe, L., J. Li, M.Lilly et al. Nontransformed colony-derived stromal cell lines from normal human marrows. I. Growth requirement and myelopoiesis supportive abilitiy. Exp Hematol. 1995;23:507-513.
44. Kuznetsov, S.A., A.J. Friedenstein and P.G. Robey. Factors required for bone marrow stromal fibroblast colony formation in vitro. Br J Haematol. 1997;97:561-570.
45. Yan, Z-J., Q-R. Wang, I.K. McNiece et al. Dissecting the hematopoietic microenvironment. VII. The production of an autostimulatory factor as well as a CSF by unstimulated murine marrow fibroblasts. Exp Hematol. 1990;18:348-354.
46. Gronthos, S. and P.J. Simmons. The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood 1995;85:929-940.
47. Andrades, J.A., B. Han, J. Becerra et al. A recombinant human TGF-beta 1 fusion protein with collagen-binding domain promotes migration, growth, and differentiation of bone marrow mesenchymal cells. Exp Cell Res. 1999;250:485-498.
48. Satomura, K., A.R. Derubeis, N.S. Fedarko et al. Receptor tyrosine kinase expression in human bone marrow stromal cells. J Cell Physiol. 1998;177:426-328.
49. Wang, M., L.J. Guilbert, L. Ling et al. Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax Quinquefolium). J Pharm Pharmacol. 1002;22:1515-1523.
50. Wang, M., L. J. Guilbert, J. Li et al. A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-γ production in murine spleen cells induced by Con-A. Int Immunopharm.2004;4:311- 315.
51. Bianco, P., M. Riminucci, S. Kuznetsov et al. Multipotential cells in the bone marrow stroma: regulation in the context of organ physiology. Crit Rev Eukaryot Gene Expr. 1999; 9:159-173.
52. Bianco, P. and P.G. Robey. Marrow stromal stem cells. J Clin Invest. 2000;105(12):1663-1668.
53. Sensebe, L., B.T. Mortensen, P. Fixe et al. Cytokines active on granulomonopoiesis: release and consumption by human marrow myeloid stromal cells. Br J Haematol. 1997;98:274-282.
54. Mohr, A.M., J.S. Upperman, R. Taneja et al. Differential effects of acute hypoxia and endotoxin on the secretion and expression of bone marrow interleukin-1 and interleukin-6. Shock 1997;7(5):324-331.
55. Hubin, F., C. Humblet, Z. Belaid et al. Murine bone marrow stromal cells sustain in vivo the survival of hematopoietic stem cells and the granulopoietic differentiation of more mature progenitors. Stem Cells 2005;23(10):1626-1633.
56. Di Carlo, E., G. Forni, P.L. Lollini et al. The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood 2001;97(2):339-345.
57. Giovarelli, M., P. Cappello, G. Forni et al. Tumor rejection and immune memory elicited by locally released IEC chemokine are associated with an impressive recruitment of antigen-presenting cells, lymphocytes and granulocytes. J Immunol 2000;164:3200-3206.
58. Kindzelski, A.L. and H.R. Petty. Early membrane rupture events during neutrophil-mediated antibody-dependent tumor cell cytolysis. J Immunol 1999;162:3188-3192.
59. Otten, M.A., E. Rudolph, M. Dechant et al. Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors. J Immunol 2005; 174(9):5472-5480.
60. Okrent, D.G., A.K. Lichtenstein and T. Ganz. Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. Am Rev Respir Dis 1990;141:179-185.