Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome

Pediatric Reports

Volumn 3, Issue 2, 2011, Pages

  Farruggia, Piero ^a   Macaluso, Alessandra ^a   Tropia, Serena ^a   Genova, Selene ^a   Paolicchi, Olivia ^b   Di Marco, Floriana ^a   D'Angelo, Paolo ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cyclosporine; Evans syndrome; Mycophenolate mofetil; Outcome; Treatment

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN; HEMOGLOBIN; IMMUNOGLOBULIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RITUXIMAB; VINCRISTINE;

ABSENCE OF SIDE EFFECTS; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; CASE REPORT; CHILD; CHILD HEALTH CARE; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ERYTHROCYTE COUNT; EYE JAUNDICE; FEMALE; HEPATOMEGALY; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; LEUKOCYTE COUNT; PALLOR; PETECHIA; PRESCHOOL CHILD; RETICULOCYTE COUNT;

EID: 83655182403     PISSN: None     EISSN: 20367503     Source Type: Journal    
DOI: 10.4081/pr.2011.e15     Document Type: Article

References (15)

1. Petz LD, Garratty G. Immune hemolytic anemias. New York: Churchill Livingstone, 2004.
2. Savasan S, Warrier I, Ravindranath Y. The spectrum of Evans' syndrome. Arch Dis Child 1997;77:245-8.
3. Blouin P, Auvrignon A, Pagnier A, et al. Evans' syndrome: a retrospective study from the ship (French Society of Pediatric Hematology and Immunology) (36 cases). Arch Pediatr 2005;12:1600-7.
4. Friedmann AM, King KE, Shirey RS, et al. Fatal autoimmune hemolytic anemia in a child due to warm-reactive immunoglobulin M antibody. J Pediatr Hematol Oncol 1998;20: 502-5.
5. Nuss R, Wang W. Intravenous gamma globulin for thrombocytopenia in children with Evans syndrome. Am J Pediatr Hematol Oncol 1987;9:164-7.
6. Zecca M, Nobili B, Ramenghi U, et al. Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood 2003;101:3857-61.
7. Carson KR, Evens AM, Richey EA, et al. Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood 2009;113:4834-40.
8. Scaradavou A, Bussel J. Evans syndrome. Results of a pilot study utilizing a multiagent treatment protocol. J Pediatr Hematol Oncol 1995;17:290-5.
9. Gombakis N, Trahana M, Athanassiou M, Kanakoudi-Tsakalidou F. Evans syndrome: successful management with multi-agent treatment including intermediate-dose intravenous cyclophosphamide. J Pediatr Hematol Oncol 1999;21:248-9.
10. Zimmer-Molsberger B, Knauf W, Thiel E. Mycophenolate mofetil for severe autoimmune haemolytic anemia. Lancet 1997;350:1003-4.
11. Kotb R, Pinganaud C, Trichet C, et al. Efficacy of mycophenolate mofetil in adult refractory auto-immune cytopenias: a single center preliminary study. Eur J Haematol 2005;75:60-4.
12. Hershko C, Sonnenblick M, Ashkenazi J. Control of steroid-resistant autoimmune haemolytic anaemia by cyclosporine. Br J Haematol 1990;76:436-7.
13. Uçar B, Akgün N, Aydodu SD, et al. Treatment of refractory Evans' syndrome with cyclosporine and prednisone. Pediatr Int 1999; 41:104-7.
14. Guirat Dhouib N, Mellouli F, Kouki R, Bejaoui M. Successful treatment of Mycophenolate Mofetil in a child with refractory Evans Syndrome. J Pediatr Hematol Oncol 2010;32:e2 44.
15. Caselli D, Farruggia P, Trizzino A, et al. Split chimerism may be enough to cure Evans syndrome. Bone Marrow Transplant 2006;38:311.