Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 1-2, 2012, Pages 184-189

  Onoue, Satomi ^a   Matsui, Takuya ^a   Aoki, Yosuke ^a   Ishida, Hitoshi ^a   Nukaya, Haruo ^a   Kou, Keitatsu ^b   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway inflammation; Biomarker; Chafuroside A; Dissolution; Self assembled micellar formulation

Indexed keywords

ANTIGEN; BIOLOGICAL MARKER; CHAFUROSIDE A; CRYSTALLIN; FLAVONE DERIVATIVE; MYELOPEROXIDASE; UNCLASSIFIED DRUG; WATER;

AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; ATTENUATION; CELL INFILTRATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; GRANULOCYTE; INFLAMMATION; MACROPHAGE; MACROPHAGE MIGRATION; MALE; MICELLE; MICELLIZATION; MORPHOLOGY; NEUTROPHIL CHEMOTAXIS; NEUTROPHILIA; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT DISEASE; SELF ASSEMBLED MICELLAR SYSTEM; SYMPTOM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONES; GLYCOSIDES; GRANULOCYTES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; MALE; MICELLES; NANOSTRUCTURES; PEROXIDASE; PHAGOCYTES; PHYSICOCHEMICAL PHENOMENA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 83655181013     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.11.003     Document Type: Article

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