The Use of Ginger (Zingiber officinale) for the Treatment of Pain: A Systematic Review of Clinical Trials

Pain Medicine

Volumn 12, Issue 12, 2011, Pages 1808-1818

  Terry, Rohini ^a   Posadzki, Paul ^a   Watson, Leala K ^a   Ernst, Edzard ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Pain; Systematic Review; Zingiber officinale

Indexed keywords

(10) GINGEROL; (6) GINGEROL; (8) GINGEROL; GINGER EXTRACT; IBUPROFEN; MEFENAMIC ACID; PLACEBO; SHOGAOL;

ACUTE MUSCLE PAIN; ARTICLE; CINAHL; CLINICAL ASSESSMENT; CLINICAL PROTOCOL; CLINICAL TRIAL (TOPIC); CONTROLLED CLINICAL TRIAL (TOPIC); DRUG COST; DRUG EFFICACY; DRUG WITHDRAWAL; DYSMENORRHEA; EVIDENCE BASED MEDICINE; GINGER; HEALTH CARE QUALITY; HEARTBURN; HUMAN; JADAD SCALE; LIVER TOXICITY; MCGILL PAIN QUESTIONNAIRE; META ANALYSIS; MYALGIA; NEPHROTOXICITY; OSTEOARTHRITIS; PAIN; PAIN ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); RATING SCALE; RISK ASSESSMENT; SYSTEMATIC REVIEW; TASTE DISORDER; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

EID: 83655167131     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2011.01261.x     Document Type: Review

References (27)

1. Antman EM, Bennett JS, Daugherty A, etal. Use of non-steroidal anti-inflammatory drugs. An update for clinicians. A scientific statement from the American Heart Association. Circulation 2007;115:1634-42.
2. Ali B, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol 2008;46:409-20.
3. Awang D. Ginger. Can Pharm J 1992;125:309-11.
4. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 2001;44(11):2531-8.
5. Ernst E, Pittler M. Alternative therapy bias. Nature 1997;385(6616):480.
6. Iwaskai Y, Morita A, Iwasawa T, etal. A nonpungent component of steamed ginger-(10) shogaol-increases adrenaline secretion via the activation of TRPV1. Nutr Neurosci 2006;9:169-78.
7. Jana U, Chattiopadhayay R, Shaw B. Preliminary studies on anti-inflammatory activity of Zingiber officinale Rosc., Vitex negundo Linn., and Tinospora cordifolia (Widdid) miers in albino rats. Indian J Pharmacol 1993;31:232-3.
8. Kiuchi F, Iwakami S, Shibuya M, Hanaoka F, Sandaw U. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo) 1992;40:387-91.
9. Lanz R, Chen G, Sarihan M, etal. The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 2007;14:123-8.
10. Black CD, Herring MP, Hurley D, O'Connor PJ. Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain 2010;11(9):894-903.
11. Leach MJ, Kumar S. The clinical effectiveness of ginger (Zingiber officinale) in adults with osteoarthritis. Int J Evid Based Healthc 2008;6:311-20.
12. Liberati A, Altman DG, Tetzlaff J, etal. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. J Clin Epidemiol 2009;62(10):e1-34.
13. Jadad A, Moore R, Carrol D. Assessing the quality of reports of randomized controlled trials: Is blinding necessary? Control Clin Trials 1996;17(1):1-12.
14. Gagnier JJ, Boon H, Rochon P, etal. Reporting randomized, controlled trials of herbal interventions: An elaborated CONSORT statement. Ann Intern Med 2006;155(5):364-7.
15. Black CD, O'Conner PJ. Acute effects of dietary ginger on quadriceps muscle pain during moderate intensity cycling exercise. Int J Sport Nutr Exerc Metab 2008;18:653-64.
16. Black CD, O'Conner PJ. Acute effects of dietary ginger on muscle pain induced by eccentric exercise. Phytother Res 2010;24(11):1620-6.
17. Bliddal H, Rosetzsky A, Schlinchting P, etal. A randomized, placebo-controlled cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage 2000;8(1):9-12.
18. Haghighi M, Khalva A, Toliat T, Jallaei S. Comparing the effects of ginger (Zingiber officinale) extract and ibuprofen on patients with osteoarthritis. Arch Iran Med 2005;8(4):267-71.
19. Ozgoli G, Marjan G, Moattar F. Comparison of effects of ginger, mefenamic acid and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med 2009;15(2):129-32.
20. Wigler I, Neumann L, Yaron M. Validation study of a Hebrew version of WOMAC in patients with osteoarthritis of the knee. Clin Rheumatol 1999;5:402-51.
21. Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-9.
22. Chrubasik S, Pittler M, Roufogalis B. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 2005;12(9):684-701.
23. Easterbrook P, Berlin J, Gopalan R, Mathews D. Publication bias in clinical research. Lancet 1997;337:867-72.
24. Graham S. Narrative versus meta-analytic reviews of race differences in motivation: A comment on Cooper and Dorr. Rev Educ Res 1995;65(4):509-14.
25. Dworkin RH, Turk DC, Peirce-Sandner S, etal. Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations. Pain 2010;149:177-93.
26. Moore RA, Eccleston C, Derry S, etal. "Evidence" in chronic pain-Establishing best practice in reporting of systematic reviews. Pain 2011;150:386-9.
27. Westermarck T, Selga G, Sauka M, Aboltina L, Davidova A. Effects of dietary supplementation with ginger extract in osteoarthritis. A double blind controlled study. Ther Drug Monit 2005;27:259.