Delivery of chimeric hepatitis B core particles into liver cells

Journal of Applied Microbiology

Volumn 112, Issue 1, 2012, Pages 119-131

  Lee, K W ^a   Tey, B T ^a,b   Ho, K L ^a   Tan, W S ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Fluorescein labelling; Fusion protein; Hepatitis B core antigen; Nanoparticles; Specific cell delivery; Virus capsid

Indexed keywords

CELLS; CYTOLOGY; ESCHERICHIA COLI; FLUORESCENCE MICROSCOPY; LIGANDS; PROTEINS; VIRUSES;

CELL DELIVERY; FLUORESCEIN LABELING; FUSION PROTEINS; HEPATITIS B; HEPATITIS B CORE ANTIGEN; LABELINGS; LIVER CELLS; SPECIFIC CELL DELIVERY; VIRUS CAPSID; VIRUS-LIKE PARTICLES;

ANTIGENS;

CHIMERIC PROTEIN; HYBRID PROTEIN; NANOCARRIER; PRESIHIS6HBCAG FUSION PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN; CHIMERA; COLIFORM BACTERIUM; CYTOLOGY; GENETIC ENGINEERING; HEPATITIS; LIGAND; MICROSCOPY; NANOTECHNOLOGY; PARTICLE SIZE; PROTEIN; VIRUS;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRAIN HEPG2; COLLOIDAL GOLD IMMUNOELECTRON MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRON MICROSCOPY; ESCHERICHIA COLI; FEMALE; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; SOLUBILITY; TARGET CELL; TRANSMISSION ELECTRON MICROSCOPY; VIRUS LIKE AGENT;

ESCHERICHIA COLI; HEPATITIS B VIRUS; MIRIDAE;

EID: 83555178430     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2011.05176.x     Document Type: Article

References (36)

1. Bar, H., Yacoby, I. and Benhar, I. (2008) Killing cancer cells by targeted drug-carrying phage nanomedicines. BMC Biotechnol 8, 1-14.
2. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.
3. Bruss, V., Hagelstein, J., Gerhardt, E. and Galle, P.R. (1996) Myristylation of the large surface protein is required for hepatitis B virus in vitro infectivity. Virology 218, 396-399.
4. Chang, D.K., Lin, C.T., Wu, C.H. and Wu, H.C. (2009) A novel peptide enhances therapeutic efficacy of liposomal anti-cancer drugs in mice models of human lung cancer. PLoS ONE 4, e4171.
5. Cooper, A. and Shaul, Y. (2005) Recombinant viral capsids as an efficient vehicle of oligonucleotide delivery into cells. Biochem Biophys Res Commun 327, 1094-1099.
6. Cooper, A. and Shaul, Y. (2006) Clathrin-mediated endocytosis and lysosomal cleavage of hepatitis B virus capsid-like core particles. J Biol Chem 281, 16563-16569.
7. De-Falco, S., Ruvo, M., Verdoliva, A., Scarallo, A., Raimondo, D., Raucci, A. and Fassina, G. (2001) N-terminal myristylation of HBV preS1 domain enhances receptor recognition. J Pept Res 57, 390-400.
8. Deng, Q., Kong, Y.Y., Xie, Y.H. and Wang, Y. (2005) Expression and purification of the complete PreS region of hepatitis B virus. World J Gastroenterol 11, 3060-3064.
9. Ganem, D. (1991) Assembly of hepadnaviral virions and subviral particles. Curr Topics Microbiol Immunol 168, 61-83.
10. Glebe, D. and Urban, S. (2007) Viral and cellular determinants involved in hepadnaviral entry. World J Gastroenterol 13, 22-38.
11. Gripon, P., Le-Seyec, J., Rumin, S. and Guguen-Guillouzo, C. (1995) Myristylation of the hepatitis B virus large surface protein is essential for viral infectivity. Virology 213, 292-299.
12. Iwasaki, Y., Ueda, M., Yamada, T., Kondo, A., Seno, M., Tanizawa, K., Kuroda, S., Sakamoto, M. et al. (2007) Gene therapy of liver tumors with human liver-specific nanoparticles. Cancer Gene Ther 14, 74-81.
13. Kazaks, A., Borisova, G., Cvetkova, S., Kovalevska, L., Ose, V., Sominskaya, I., Pumpens, P., Skrastina, D. et al. (2004) Mosaic hepatitis B virus core particles presenting the complete preS sequence of the viral envelope on their surface. J Gen Virol 85, 2665-2670.
14. Kho, C.L., Tan, W.S. and Yusoff, K. (2001) Production of the nucleocapsid protein of Newcastle disease virus in Escherichia coli and its assembly into ring- and nucleocapsid-like particles. J Microbiol 39, 293-299.
15. Kratz, P.A., Böttcher, B. and Nassal, M. (1999) Native display of complete foreign protein domains on the surface of hepatitis B virus capsids. Proc Natl Acad Sci USA 96, 1915-1920.
16. Le Duff, Y., Blanchet, M. and Sureau, C. (2009) The pre-S1 and antigenic loop infectivity determinants of the hepatitis B virus envelope proteins are functionally independent. J Virol 83, 12443-12451.
17. Lee, K.W. and Tan, W.S. (2008) Recombinant hepatitis B virus core particles: association, dissociation and encapsidation of green fluorescent protein. J Virol Methods 151, 172-180.
18. Lin, Y., Liu, Y.X., Cislo, T., Mason, B.L. and Yu, M.Y. (1991) Expression and characterization of the preS1 peptide of hepatitis B surface antigen in Escherichia coli. J Med Virol 33, 181-187.
19. Maeng, C.Y., Oh, M.S., Park, I.H. and Hong, H.J. (2001) Purification and structural analysis of the hepatitis B virus preS1 expressed from Escherichia coli. Biochem Biophys Res Commun 282, 787-792.
20. Nassal, M., Skamel, C., Vogel, M., Kratz, P.A., Stehle, T., Wallich, R. and Simon, M.M. (2008) Development of hepatitis B virus capsids into a whole-chain protein antigen display platform: new particulate Lyme disease vaccines. Int J Med Microbiol 298, 135-142.
21. Ng, M.Y., Tan, W.S., Abdullah, N., Ling, T.C. and Tey, B.T. (2006) Heat treatment of unclarified Escherichia coli homogenate improved the recovery efficiency of recombinant hepatitis B core antigen. J Virol Methods 137, 134-139.
22. Núñez, E., Wei, X., Delgado, C., Rodríguez-Crespo, I., Yélamos, B., Gómez-Gutiérrez, J., Peterson, D.L. and Gavilanes, F. (2001) Cloning, expression, and purification of histidine-tagged preS domains of hepatitis B virus. Protein Expr Purif 21, 183-191.
23. Qian, B., Shen, H., Xiong, J., Chen, L., Zhang, L., Jia, J., Wang, Y., Zhang, Z. et al. (2006) Expression and purification of the synthetic preS1 gene of hepatitis B virus with preferred Escherichia coli codon preference. Protein Expr Purif 48, 74-80.
24. Skamel, C., Ploss, M., Böttcher, B., Stehle, T., Wallich, R., Simon, M.M. and Nassal, M. (2006) Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection. J Biol Chem 281, 17474-17481.
25. Tan, W.S., Dyson, M.R. and Murray, K. (1999) Two distinct segments of the hepatitis B virus surface antigen contribute synergistically to its association with the viral core particles. J Mol Biol 286, 797-808.
26. Tan, W.S., Dyson, M.R. and Murray, K. (2003) Hepatitis B virus core antigen: enhancement of its production in Escherichia coli, and interaction of the core particles with the viral surface antigen. Biol Chem 384, 363-371.
27. Tan, W.S., McNae, I.W., Ho, K.L. and Walkinshaw, M.D. (2007) Crystallization and X-ray analysis of the T = 4 particle of hepatitis B capsid protein with an N-terminal extension. Acta Crystallogr Sect F Struct Biol Cryst Commun 63, 642-647.
28. Tang, K.F., Abdullah, M.P., Yusoff, K. and Tan, W.S. (2007) Interactions of the hepatitis B core antigen and peptide inhibitors. J Med Chem 50, 5620-5626.
29. Tang, K.H., Yusoff, K. and Tan, W.S. (2009) Display of hepatitis B virus PreS1 peptide on bacteriophage T7 and its potential in gene delivery into HepG2 cells. J Virol Methods 159, 194-199.
30. Vogel, M., Diez, M., Eisfeld, J. and Nassal, M. (2005) In vitro assembly of mosaic hepatitis B virus capsid-like particles (CLPs): rescue into CLPs of assembly-deficient core protein fusions and FRET-suited CLPs. FEBS Lett 579, 5211-5216.
31. Whitacre, D.C., Lee, B.O. and Milich, D.R. (2009) Use of hepadnavirus core proteins as vaccine platforms. Expert Rev Vaccines 8, 1565-1573.
32. Yamada, T., Iwasaki, Y., Tada, H., Iwabuki, H., Chuah, M.K., VandenDriessche, T., Fukuda, H., Kondo, A. et al. (2003) Nanoparticles for the delivery of genes and drugs to human hepatocytes. Nat Biotechnol 21, 885-890.
33. Yap, W.B., Tey, B.T., Ng, M.Y., Ong, S.T. and Tan, W.S. (2009) N-terminally His-tagged hepatitis B core antigens: construction, expression, purification and antigenicity. J Virol Methods 160, 125-131.
34. Yap, W.B., Tey, B.T., Alitheen, N.B. and Tan, W.S. (2010) Purification of His-tagged hepatitis B core antigen from unclarified bacterial homogenate using immobilized metal affinity-expanded bed adsorption chromatography. J Chromatogr A 1217, 3473-3480.
35. Yin, Y., Xu, J. and Chen, W. (2010) Hepatitis B virus core protein as an epitope vaccine carrier: a review. Sheng Wu Gong Cheng Xue Bao 26, 431-438.
36. Yu, D., Amano, C., Fukuda, T., Yamada, T., Kuroda, S., Tanizawa, K., Kondo, A., Ueda, M. et al. (2005) The specific delivery of proteins to human liver cells by engineered bio-nanocapsules. FEBS J 272, 3651-3660.