A population balance equation model of aggregation dynamics in Taxus suspension cell cultures

Biotechnology and Bioengineering

Volumn 109, Issue 2, 2012, Pages 472-482

  Kolewe, Martin E ^a   Roberts, Susan C ^a   Henson, Michael A ^a  

^a University of Massachusetts   (United States)

Author keywords

Applied biological modeling; Bioprocess engineering; Cell aggregation; Paclitaxel; Plant cell culture; Population balance equations; Taxus

Indexed keywords

BIOLOGICAL MODELING; BIOPROCESS ENGINEERING; CELL AGGREGATION; PACLITAXEL; PLANT CELLS; POPULATION BALANCE EQUATION; TAXUS;

AGGREGATES; BIOMASS; CELLS; PLANT CELL CULTURE; POPULATION STATISTICS; PROCESS MONITORING; SIZE DISTRIBUTION;

BATCH CELL CULTURE;

PACLITAXEL;

AGGREGATE BREAKAGE; ARTICLE; BIOMASS PARTITIONING; BIOREACTOR; CELL AGGREGATION; CELL GROWTH; CELL SIZE; CELLULAR PARAMETERS; CONTROLLED STUDY; INTERMETHOD COMPARISON; KERNEL METHOD; MATHEMATICAL MODEL; MICROENVIRONMENT; NONHUMAN; PLANT CELL CULTURE; PREDICTION; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; SHEAR STRESS; SUSPENSION CELL CULTURE; TAXUS CUSPIDATA; VALIDATION PROCESS;

ALGORITHMS; BIOMASS; BIOREACTORS; CELL AGGREGATION; CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; METABOLIC ENGINEERING; MODELS, BIOLOGICAL; PACLITAXEL; PARTICLE SIZE; REPRODUCIBILITY OF RESULTS; TAXUS;

TAXUS;

EID: 83555172555     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23321     Document Type: Article

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