Ascorbic acid prevents vascular dysfunction induced by oral glucose load in healthy subjects

European Journal of Internal Medicine

Volumn 23, Issue 1, 2012, Pages 54-57

  De Marchi, Sergio ^a   Prior, Manlio ^a   Rigoni, Anna ^a   Zecchetto, Sara ^a   Rulfo, Fanny ^a   Arosio, Enrico ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

Ascorbic acid; Endothelial function; Forearm resistances; Laser Doppler; Microcirculation; Plethysmography

Indexed keywords

ACETYLCHOLINE; ASCORBIC ACID; BICARBONATE; GLUCOSE; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CLINICAL ARTICLE; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; FEMALE; FOREARM BLOOD FLOW; HEART RATE; HEMODYNAMICS; HUMAN; HYPEREMIA; ISCHEMIA; LASER DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PLETHYSMOGRAPHY; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VASCULAR DISEASE;

ADMINISTRATION, ORAL; ADULT; ANTIOXIDANTS; ASCORBIC ACID; ENDOTHELIUM, VASCULAR; FEMALE; GLUCOSE; HEMODYNAMICS; HUMANS; MALE; MICROCIRCULATION;

EID: 83555165975     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2011.07.019     Document Type: Article

References (27)

1. H. Shige, T. Ishikawa, and M. Suzukawa Endothelium dependent flow mediated vasodilation in the postprandial state in type 2 diabetes mellitus Am J Cardiol 84 1999 1272 1274 (Pubitemid 29507515)
2. K.C. Chang, S.Y. Chung, W.S. Chong, J.S. Suh, Sh. Kim, and K.W. Chun Possible superoxide radical-induced alteration of vascular reactivity in aortas fro streptozocin-treated rats J Pharmacol Exp Ther 266 1993 992
3. G.M. Pieper Oxidative stress in diabetic blood vessels FASEB J 9 1995 A891
4. T. Ohkuwa, Y. Sato, and M. Naoi Hydroxyl radical formation in diabetic rats induced by streptozocin Life Sci 56 1995 1789
5. R.S. Ronson, M. Nakamura, and J.J. Vinten The cardiovascular effects and implications of peroxinitrite Cardiovasc Res 44 1999 47 59
6. F. Cosentino, K. Hishikawa, Z.S. Katusic, and T.F. Luscher High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells Circulation 96 1997 25 28 (Pubitemid 27298398)
7. S.B. Williams, A.B. Goldfine, F.H. Timimi, M.A. Roddy, D.C. Simonson, and M.A. Creager Acute hyperglycemia attenuates endothelium-dependent vasodilation in human in vivo Circulation 97 1998 1695 1701 (Pubitemid 28211418)
8. H. Kawano, T. Motoyama, and O. Hirashima Hyperglycemia rapidly suppresses flow mediated endothelium-dependent vasodilation of brachial artery J Am Coll Cardiol 34 1999 146 154
9. C.M. Akbari, R. Saouaf, D.F. Barnhill, P.A. Newman, F.W. LoGerfo, and A. Veves Endothelium dependent vasodilation is impaired in both microcirculation and macrocirculation during acute hyperglycemia J Vasc Surg 28 1998 687 694 (Pubitemid 28481224)
10. M. Massi Benedetti, and M.O. Federici Cardiovascular risk factors in type 2 diabetes: the role of hyperglycemia Exp Clin Endocrinol Diabetes Suppl 4; S 1999 120 123
11. B. Frei On the role of vitamin C and other antioxidants in athrogenesis and vascular dysfunction Proc Soc Exp Biol Med 222 1999 196 204 (Pubitemid 129708634)
12. N. Gokce, J.F. Keaney, and B. Frei Long term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease Circulation 99 1999 3234 3240 (Pubitemid 29293432)
13. F. Nappo, N. De Rosa, and R. Marfella Impairment of endothelial functions by acute hyperhomocisteinemia and reversal by antioxidant vitamins Jama 281 1999 2113 2118 (Pubitemid 29264690)
14. S. Taddei, A. Virdis, L. Ghiadoni, A. Magagna, and A. Salvetti Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension Circulation 97 1998 2222 2229 (Pubitemid 28265383)
15. K. Morris Vitamin C restores early coronary impairments in smokers Lancet 356 9234 2000 1007
16. J.A. Beckman, A.B. Goldfine, M.B. Gordon, and M.A. Creager Ascorbate restores endothelium dependent vasodilation impaired by acute hyperglycemia in humans Circulation 103 2001 1618
17. G. Arcaro, A. Cretti, S. Balzano, M. Muggeo, E. Bonora, and R.C. Bonadonna Insulin causes endothelial dysfunction in humans: sites and mechanism Circulation 5;105 2002 576 582 (Pubitemid 34123431)
18. R. Del guercio Evaluation of postischemic hyperemia on the skin using laser Doppler velocimetry: study on patients with claudication intermittens Microvasc Res 32 1986 286
19. E. Arosio, S. De Marchi, M. Prior, M. Zannoni, and A. Lechi Effects of nebivolol and atenolol on small arteries and microcirculatory endothelium-dependent dilation in hypertensive patients undergoing isometric stress J Hypertens 20 9 2002 1793 1797
20. P.C. Johnson Microvascular regulation: normal function and disturbance in disease H. Manabe, B.W. Zweifach, K. Messmer, Microcirculation in circulatory disorders 1988 Springer-Verlag Tokyo
21. L.M. Title, P.M. Cummings, K. Giddens, and B.A. Nassar Oral glucose loading acutely attenuates endothelium dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E J Am Coll Cardiol 36 2000 2185 2191
22. W. Zhu, C. Zhong, Y. Yu, and K. Li Acute effects of hyperglycaemia with and without exercise on endothelial function in healthy young men Eur J Appl Physiol 99 2007 585 591 (Pubitemid 46404016)
23. A. Siafarikas, K. Watts, P. Beye, T.W. Jones, E.A. Davis, and D.J. Green Lack of effect of oral glucose loading on conduit vessel endothelial function in healthy subjects Clin Sci 107 2004 191 196 (Pubitemid 39070936)
24. K.A. Engelke, J.R. Halliwill, D.N. Proctor, N.M. Dietz, and M.J. Joyner Contribution of nitric oxide and prostaglandins to reactive hyperemia in the human forearm J Appl Physiol 81 1996 1807 1814 (Pubitemid 26349642)
25. N. Dakak, S. Husain, and D. Mulchy Contribution of nitric oxide to reactive hyperemia Hypertension 32 1998 9 15
26. M. Ghyczy, and M. Boros Electrophilic methyl groups present in the diet ameliorate pathological states induced by reductive and oxidative stress: a hypothesis Br J Nutr 85 2001 409 414 (Pubitemid 32435534)
27. E. Arosio, S. De Marchi, M. Prior, A. Rigoni, and A. Lechi Haemodynamic effects of AT1 inhibition and Ca2+-channel blockade in hypertensive patients during isometric stress J Hum Hypertens 20 3 2006 201 205