Treating neonates with levetiracetam: A survey among German University Hospitals

Klinische Padiatrie

Volumn 223, Issue 7, 2011, Pages 450-452

  Koppelstetter, A ^a   Bhrer, C ^a   Kaindl, A M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

antiepileptic drug; epilepsy; levetiracetam; neonatal seizures

Indexed keywords

ETIRACETAM; PHENOBARBITAL; ANTICONVULSIVE AGENT; DRUG DERIVATIVE; PIRACETAM;

AGITATION; ARTICLE; FATIGUE; GERMANY; HEMATOCHEZIA; HUMAN; HYPERKINESIA; LIVER DYSFUNCTION; NEWBORN; NEWBORN CARE; OFF LABEL DRUG USE; PREMATURITY; SEDATION; SEIZURE; SIDE EFFECT; SLEEP DISORDER; THROMBOCYTOPENIA; UNIVERSITY HOSPITAL; DRUG UTILIZATION; HEALTH SURVEY; INFANTILE SPASM; NEWBORN DISEASE; STATISTICS;

ANTICONVULSANTS; DRUG UTILIZATION; GERMANY; HEALTH SURVEYS; HOSPITALS, UNIVERSITY; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; OFF-LABEL USE; PIRACETAM; SPASMS, INFANTILE;

EID: 83555164586     PISSN: 03008630     EISSN: 14393824     Source Type: Journal    
DOI: 10.1055/s-0031-1287822     Document Type: Article

References (18)

1. Abend N S, Gutierrez-Colina A M, Monk H M et al. Levetiracetam for treatment of neonatal seizures. J Child Neurol: 2011; 26 465 470
2. Bittigau P, Sifringer M, Genz K et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA: 2002; 99 15089 15094 (Pubitemid 35334614)
3. Frwentsches A, Bussmann C, Ramantani G et al. Levetiracetam in the treatment of neonatal seizures: a pilot study. Seizure: 2010; 19 185 189
4. Garfinkle J, Shevell M I. Cerebral palsy, developmental delay, and epilepsy after neonatal seizures. Pediatr Neurol: 2011; 44 88 96
5. Glauser T A, Ayala R, Elterman R D et al. N159 Study Group. Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures. Neurology: 2006; 66 1654 1660 (Pubitemid 43964617)
6. Harden C. Safety profile of levetiracetam. Epilepsia: 2001; 42 04 36 39 (Pubitemid 32802086)
7. Ikonomidou C, Scheer I, Wilhelm T et al. Brain morphology alterations in the basal ganglia and the hypothalamus following prenatal exposure to antiepileptic drugs. Eur J Paediatr Neurol: 2007; 11 297 301 (Pubitemid 47194447)
8. Kaindl A M, Koppelstaetter A, Nebrich G et al. Brief alteration of NMDA or GABAA receptor-mediated neurotransmission has long term effects on the developing cerebral cortex. Mol Cell Proteomics: 2008; 7 2293 2310
9. Khan O, Chang E, Cipriani C et al. Use of intravenous levetiracetam for management of acute seizures in neonates. Pediatr Neurol: 2011; 44 265 269
10. Manthey D, Asimiadou S, Stefovska V et al. Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain. Exp Neurol: 2005; 193 497 503 (Pubitemid 40616197)
11. Prandstetter C, Tamesberger M, Wagner O et al. Medical prescriptions to premature and newborn infants in an Austrian neonatal intensive care unit. Klin Padiatr: 2009; 221 312 317
12. Ramantani G, Ikonomidou C, Walter B et al. Levetiracetam: safety and efficacy in neonatal seizures. Eur J Paediatr Neurol: 2011; 15 1 7
13. Roth B. Off-label and unlicensed use of drugs in neonatal intensive care. Klin Padiatr: 2009; 221 275 277
14. Shoemaker M T, Rotenberg J S. Levetiracetam for the treatment of neonatal seizures. J Child Neurol: 2007; 22 95 98 (Pubitemid 46860448)
15. Silverstein F S, Ferriero D M. Off-label use of antiepileptic drugs for the treatment of neonatal seizures. Pediatr Neurol: 2008; 39 77 79 (Pubitemid 351970659)
16. Stefovska V G, Uckermann O, Czuczwar M et al. Sedative and anticonvulsant drugs suppress postnatal neurogenesis. Ann Neurol: 2008; 64 434 445
17. Sulzbacher S, Farwell J R, Temkin N et al. Late cognitive effects of early treatment with phenobarbital. Clin Pediatr (Phila): 1999; 38 387 394 (Pubitemid 29328298)
18. Vento M, de Vries L S, Alberola A et al. Approach to seizures in the neonatal period: a European perspective. Acta Paediatr: 2010; 99 497 501