Biodegradable ocular inserts for sustained delivery of brimonidine tartarate: Preparation and in vitro/in vivo evaluation

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1335-1347

  Aburahma, Mona Hassan ^a   Mahmoud, Azza Ahmed ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

brimonidine; intraocular pressure; ocular insert; physicochemical characterization; sustained release

Indexed keywords

ALGINIC ACID; BRIMONIDINE; CARBOMER; CHITOSAN; ETHYL CELLULOSE; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; POVIDONE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG RELEASE; DRUG TOLERABILITY; EXPERIMENTAL RABBIT; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; INTRAOCULAR PRESSURE; MALE; MEAN RESIDENCE TIME; MOLECULAR WEIGHT; NONHUMAN; OCULAR INSERT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SLIT LAMP; TIME TO MAXIMUM PLASMA CONCENTRATION; VISCOSITY; X RAY DIFFRACTION;

ABSORBABLE IMPLANTS; ADMINISTRATION, OPHTHALMIC; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ALGINATES; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; GLAUCOMA; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTRAOCULAR PRESSURE; KINETICS; METHYLCELLULOSE; OPHTHALMIC SOLUTIONS; POLYMERS; POLYMETHACRYLIC ACIDS; POLYVINYLS; POVIDONE; QUINOXALINES; RABBITS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 83555160860     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9701-3     Document Type: Article

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