Vascular endothelial growth factor polymorphisms are involved in the late vascular complications in Type II diabetic patients

Diabetes and Vascular Disease Research

Volumn 9, Issue 1, 2012, Pages 68-74

  Bleda, Silvia ^a   De Haro, Joaquin ^a   Varela, Cesar ^a   Esparza, Leticia ^a   Ferruelo, Antonio ^a   Acin, Francisco ^a  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

Author keywords

Diabetic retinopathy; peripheral arterial disease; VEGF polymorphisms

Indexed keywords

VASCULOTROPIN;

AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DNA POLYMORPHISM; FEMALE; GENE DELETION; GENE INSERTION; GENOTYPE; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL OCCLUSIVE ARTERY DISEASE; RETINOPATHY;

AGED; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; GENE DELETION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; ODDS RATIO; PERIPHERAL ARTERIAL DISEASE; PHENOTYPE; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; SPAIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 83455258049     PISSN: 14791641     EISSN: 17528984     Source Type: Journal    
DOI: 10.1177/1479164111426162     Document Type: Article

References (19)

1. Churchill AJ, Carter JG, Ramsden C, Turner SJ, Yeung A, Brenchley PE, et al. VEGF polymorphisms are associated with severity of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008 ; 49: 3611-3616
2. Howell WM, Ali S, Rose-Zerilli MJ, Ye S. VEGF polymorphisms and severity of atherosclerosis. J Med Genet. 2005 ; 42: 485-490 (Pubitemid 40847236)
3. Aiello LP, Wong JS. Role of vascular endothelial growth factor in diabetic vascular complications. Kidney Int Suppl. 2000 ; 77: S113-119
4. Petrovan RJ, Kaplan CD, Reisfeld RA, Curtiss LK. DNA vaccination against VEGF receptor 2 reduces atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2007 ; 27: 1095-1100 (Pubitemid 46641963)
5. Stehr A, Töpel I, Muller S, Unverdorben K, Geissler EK, Kasprzak PM, et al. VEGF: a surrogate marker for peripheral vascular disease. Eur J Vasc Endovasc Surg. 2010 ; 39: 330-332
6. Tsurumi Y, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinhal T, et al. Reciprocal relationship between VEGF and NO in the regulation of endothelial integrity. Nature Med. 1997 ; 3: 879-886 (Pubitemid 27353448)
7. Oh IK, Kim SW, Oh J, Lee TS, Huh K. Inflammatory and angiogenic factors in the aqueous humor and the relationship to diabetic retinopathy. Curr Eye Res. 2010 ; 35: 1116-1127
8. Michaelides M, Kaines A, Hamilton RD, Fraser-Bell S, Rajendram R, Quhill F, et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT Study). Ophthalmology. 2010 ; 117: 1078-1086
9. Buraczynska M, Ksiazek P, Baranowicz-Gaszczyk I, Jozwiak L. Association of the VEGF gene polymorphism with diabetic retinopathy in type 2 diabetes patients. Nephrol Dial Transplant. 2007 ; 22: 827-832 (Pubitemid 46351692)
10. Biselli PM, Guerzoni AR, de Godoy MF, Pavarino-Bertelli EC, Goloni-Bertollo EM. Vascular endothelial growth factor genetic variability and coronary artery disease in Brazilian population. Heart Vessels. 2008 ; 23: 371-375
11. Grading diabetic retinopathy from stereoscopic color fundus photographs- an extension of the modified Airline House classification. ETDRS report number 10. Ophthalmology. 1991 ; 98: 786-806
12. Ohashi J, Yamamoto S, Tsuchiya N, Hatta Y, Komata T, Matsushita M, et al. Comparison of statistical power between 2 × 2 allele frequency and allele positivity tables in case-control studies of complex disease genes. Ann Hum Genet. 2001 ; 65: 197-206 (Pubitemid 32452121)
13. Mundet X, Cano F, Mata-Cases M, Roura P, Franch J, Birutes M, et al Prim Care Diabetes. 2011 :
14. De Haro J, Acin F, López-Quintana A, Florez A, Martinez-Aguilar E, Varela C. Meta-analysis of randomized, controlled clinical trials in angiogenesis: gene and cell therapy in peripheral arterial disease. Heart Vessels. 2009 ; 24: 321-328
15. Abdallah W, Fawzi AA. Anti-VEGF therapy in proliferative diabetic retinopathy. Int Ophthalmol Clin. 2009 ; 49: 95-107
16. Awata T, Inoue K, Kurihara S, Ohkubo T, Watanabe M, Inukai K, et al. A common polymorphism in the 5′-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes. 2002 ; 51: 1635-1639 (Pubitemid 34826636)
17. Nakamura S, Iwasaki N, Funatsu H, Kinato S, Iwamoto Y. Impact of variants in the VEGF gene on progression of proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2009 ; 247: 21-26
18. Ray D, Mishra M, Ralph S, Read J, Davies R, Brenchley P. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes. 2004 ; 53: 861-864 (Pubitemid 38270661)
19. Szaflik JP, Wysocki T, Kowalski M, Majsterek I, Borucka AI, Blasiak J, et al. An association between vascular endothelial growth factor gene promoter polymorphisms and diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2008 ; 246: 39-43 (Pubitemid 350162682)