Synthesis and anti-tumor activity of oleanolic acid derivatives

Yaoxue Xuebao

Volumn 46, Issue 10, 2011, Pages 1215-1220

  Meng, Yan Qiu ^a   Nie, Hui Hui ^a   Wang, Xiao Chen ^a   Li, Dan ^a   Ge, Chong Xun ^a   Zhao, Na ^a   Chen, Hong ^b   Cao, Bo ^b  

^a SHENYANG UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Anti tumor activity; Oleanolic acid; Pentacyclic triterpenoid

Indexed keywords

ETOPOSIDE; GEFITINIB; OLEANOLIC ACID; OLEANOLIC ACID DERIVATIVE;

ACYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; OXIDATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HELA CELLS; HEP G2 CELLS; HUMANS; OLEANOLIC ACID;

EID: 83455258035     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Liu J. Pharmacology of oleanolic acid and ursolic acid [J]. J Ethnopharmacol, 1995, 49: 57-68. (Pubitemid 26010740)
2. Ovesna Z, Vachalkova A, Horvathova K, et al. Pentacyclic triterpenoic acids: new chemoprotective compounds [J]. Neoplasma, 2004, 51: 327-333. (Pubitemid 39486104)
3. Aggarwal BB, Takada Y, Oommen OV. From chemoprevention to chemotherapy common targets and common goals [J]. Expert Opin Investig Drugs, 2004, 13: 1327-1338. (Pubitemid 39359662)
4. Aparecida Resende F, de Andrade Barcala CA, da Silva Faria MC, et al. Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin induced clastogenesis in Balb/c mice [J]. Life Sci, 2006, 79: 1268-1273. (Pubitemid 44192546)
5. Gong XJ, Ding H, Qiu YS, et al. Toxicity of cyclophosphamide on primary cultured hepatocytes of rat and protective effects of oleanolic acid [J]. Her Med, 2006, 25: 1114-1116.
6. Jeong HG. Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury [J]. Toxicol Lett, 1999, 105: 215-222. (Pubitemid 29164491)
7. Hsu HY, Yang JJ, Lin CC. Effects of oleanolic acid on inhibiting tumor growth and enhancing the recovery of hematopoietic system postirradiation in mice [J]. Cancer Lett, 1997, 111: 7-13.
8. Kashiwada Y, Wang HK, Nagao T, et al. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid and structurally related triterpenoides [J]. J Nat Prod, 1998, 61: 1090-1095. (Pubitemid 28464734)
9. Ortiz Andrade RR, Garcia-Jimenez S, Castillo-Espana P, et al. α-Glucosidase inhibitory activity of the methanolic extract from Tournefortia hartwegiana: an anti-hyperglycemicagent [J]. J Ethnopharmacol, 2007, 109: 48-53. (Pubitemid 44889199)
10. Chen L, Shang J, Wang ZF, et al. Synthesis and biological evaluation of nitrate-oleanolic acid hybrids as inhibitors of HepG2 cell apoptosis [J]. Acta Pharma Sin, 2010, 45: 1516-1522.
11. Li QL, Gu J, Li LZ. Synthesis of oleanolic acid derivatives [J]. Chin J Synth Chem, 2010, 18: 290-296.
12. Huang X, Chen S, Du Y, et al. Synthesis of oleanolic acid saponins mimicking components of Chinese folk medicine Di Wu [J]. Carbohydr Res, 2009, 344: 1153-1158.
13. Liu D, Meng YQ, Zhao J, et al. Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid [J]. Chem Res Chin Univ, 2008, 24: 42-46.
14. Meng YQ, Liu D, Cai LL, et al. The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action [J]. Bioorg Med Chem, 2009, 17: 848-854.
15. Meng YQ, Liu D, Bai ZW, et al. Synthesis and anti-tumor activity of ursolic acid derivatives [J]. Acta Pharm Sin, 2011, 46: 556-560.