'Flesh-eating necrotizing infections: Must we amputate?

Expert Review of Anti-Infective Therapy

Volumn 10, Issue 1, 2012, Pages 1-3

  Bryant, Amy E ^a,b   Stevens, Dennis L ^a,b  

^a Boise VA Medical Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

gas gangrene; platelets; streptococcal myonecrosis; toxins; vascular dysfunction

Indexed keywords

BACTERIAL TOXIN; CALCIUM CHANNEL; FIBRINOGEN RECEPTOR; PHOSPHOLIPASE C; PROTEIN KINASE C; STREPTOLYSIN O;

AMPUTATION; CLINICAL FEATURE; CLOSTRIDIUM INFECTION; DEBRIDEMENT; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENZYME ACTIVITY; GROUP A STREPTOCOCCAL INFECTION; HUMAN; MOLECULARLY TARGETED THERAPY; MUSCLE NECROSIS; MYALGIA; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; TISSUE BLOOD FLOW; TREATMENT PLANNING; VASCULAR DISEASE;

AMPUTATION; BACTERIAL TOXINS; CLINICAL PROTOCOLS; CLOSTRIDIUM PERFRINGENS; FASCIITIS, NECROTIZING; GAS GANGRENE; HUMANS; NECROSIS; STREPTOCOCCUS PYOGENES; VASCULAR DISEASES;

EID: 83455244420     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.11.147     Document Type: Review

References (11)

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2. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin. Infect. Dis. 41(10), 1373-1406 (2005).
3. MacLennan JD. The histotoxic clostridial infections of man. Bacteriol. Rev. 26, 177-276 (1962).
4. Bryant AE, Bayer CR, Aldape MJ, Wallace RJ, Titball RW, Stevens DL. Clostridium perfringens phospholipase C-induced platelet/leukocyte interactions impede neutrophil diapedesis. J. Med. Microbiol. 55(Pt 5), 495-504 (2006).
5. Bryant AE, Stevens DL. The pathogenesis of gas gangrene. In: The Clostridia: Molecular Biology and Pathogenesis. Rood JI, Titball R, McClane B, Songer G (Eds). Academic Press Limited, CA, USA, 185-196 (1997).
6. Bryant AE, Chen RYZ, Nagata Y, et al. Clostridial gas gangrene I: cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of C. perfringens. J. Infect. Dis. 182(3), 799-807 (2000).
7. Bryant AE, Chen RYZ, Nagata Y, et al. Clostridial gas gangrene II: phospholipase C-induced activation of platelet gpIIb/IIIa mediates vascular occlusion and myonecrosis in C. perfringens gas gangrene. J. Infect. Dis. 182(3), 808-815 (2000).
8. Stevens DL, Titball RW, Jepson M, Bayer CR, Hayes-Schroer SM, Bryant AE. Immunization with the C-domain of a-toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens. J. Infect Dis. 190(4), 767-773 (2004).
9. Bryant AE, Bergstrom R, Zimmerman GA, et al. Clostridium perfringens invasiveness is enhanced by effects of q toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein. FEMS Immunol. Med. Microbiol. 7, 321-336 (1993).
10. Bryant AE, Bayer CR, Chen RY, Guth PH, Wallace RJ, Stevens DL. Vascular dysfunction and ischemic destruction of tissue in Streptococcus pyogenes infection: the role of streptolysin O-induced platelet/neutrophil complexes. J. Infect. Dis. 192(6), 1014-1022 (2005).
11. Bryant AE, Bayer CR, Hayes-Schroer SM, Stevens DL. Activation of platelet gpIIbIIIa by phospholipase C from Clostridium perfringens involves store-operated calcium entry. J. Infect. Dis. 187(3), 408-417 (2003).