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Volumn 6, Issue 12, 2011, Pages

A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; AROMATIC HYDROCARBON RECEPTOR 2; DROSOPHILA ENGRAILED REPRESSOR PROTEIN; ETHOXYRESORUFIN DEETHYLASE; REPRESSOR PROTEIN; UNCLASSIFIED DRUG; AHR2 PROTEIN, ZEBRAFISH; CYTOCHROME P450 1A1; MUTANT PROTEIN; PROTECTIVE AGENT; ZEBRAFISH PROTEIN;

EID: 83455231437     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028020     Document Type: Article
Times cited : (12)

References (41)
  • 1
    • 0028033592 scopus 로고
    • Tissue specific expression of the rat Ah-receptor and ARNT mRNAs
    • Carver LA, Hogenesch JB, Bradfield CA, (1994) Tissue specific expression of the rat Ah-receptor and ARNT mRNAs. Nucleic Acids Res 22: 3038-3044.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3038-3044
    • Carver, L.A.1    Hogenesch, J.B.2    Bradfield, C.A.3
  • 3
    • 34548363297 scopus 로고    scopus 로고
    • The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems
    • McMillan BJ, Bradfield CA, (2007) The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems. Mol Pharmacol 72: 487-498.
    • (2007) Mol Pharmacol , vol.72 , pp. 487-498
    • McMillan, B.J.1    Bradfield, C.A.2
  • 4
    • 27644524916 scopus 로고    scopus 로고
    • AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes
    • Karchner SI, Franks DG, Hahn ME, (2005) AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes. Biochem J 392: 153-161.
    • (2005) Biochem J , vol.392 , pp. 153-161
    • Karchner, S.I.1    Franks, D.G.2    Hahn, M.E.3
  • 5
    • 0036078619 scopus 로고    scopus 로고
    • The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 is a novel vertebrate receptor
    • Andreasen EA, Hahn ME, Heideman W, Peterson RE, Tanguay RL, (2002) The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 is a novel vertebrate receptor. Mol Pharmacol 62: 234-249.
    • (2002) Mol Pharmacol , vol.62 , pp. 234-249
    • Andreasen, E.A.1    Hahn, M.E.2    Heideman, W.3    Peterson, R.E.4    Tanguay, R.L.5
  • 6
    • 0034670093 scopus 로고    scopus 로고
    • Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions
    • Tanguay RL, Andreasen E, Heideman W, Peterson RE, (2000) Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions. Biochim Biophys Acta 1494: 117-128.
    • (2000) Biochim Biophys Acta , vol.1494 , pp. 117-128
    • Tanguay, R.L.1    Andreasen, E.2    Heideman, W.3    Peterson, R.E.4
  • 7
    • 30044442385 scopus 로고    scopus 로고
    • Identification of zebrafish ARNT1 homologs: 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the developing zebrafish requires ARNT1
    • Prasch AL, Tanguay RL, Mehta V, Heideman W, Peterson RE, (2006) Identification of zebrafish ARNT1 homologs: 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the developing zebrafish requires ARNT1. Mol Pharmacol 69: 776-787.
    • (2006) Mol Pharmacol , vol.69 , pp. 776-787
    • Prasch, A.L.1    Tanguay, R.L.2    Mehta, V.3    Heideman, W.4    Peterson, R.E.5
  • 8
    • 0242268495 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish
    • Prasch AL, Teraoka H, Carney SA, Dong W, Hiraga T, et al. (2003) Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicol Sci 76: 138-150.
    • (2003) Toxicol Sci , vol.76 , pp. 138-150
    • Prasch, A.L.1    Teraoka, H.2    Carney, S.A.3    Dong, W.4    Hiraga, T.5
  • 9
    • 0028858097 scopus 로고
    • Identification of functional domains of the aryl hydrocarbon receptor
    • Fukunaga BN, Probst MR, Reisz-Porszasz S, Hankinson O, (1995) Identification of functional domains of the aryl hydrocarbon receptor. J Biol Chem 270: 29270-29278.
    • (1995) J Biol Chem , vol.270 , pp. 29270-29278
    • Fukunaga, B.N.1    Probst, M.R.2    Reisz-Porszasz, S.3    Hankinson, O.4
  • 10
    • 0034116376 scopus 로고    scopus 로고
    • The PAS superfamily: sensors of environmental and developmental signals
    • Gu YZ, Hogenesch JB, Bradfield CA, (2000) The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol 40: 519-561.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 519-561
    • Gu, Y.Z.1    Hogenesch, J.B.2    Bradfield, C.A.3
  • 11
    • 0029073539 scopus 로고
    • Evolutionary conservation of the vertebrate Ah (dioxin) receptor: amplification and sequencing of the PAS domain of a teleost Ah receptor cDNA
    • Hahn ME, Karchner SI, (1995) Evolutionary conservation of the vertebrate Ah (dioxin) receptor: amplification and sequencing of the PAS domain of a teleost Ah receptor cDNA. Biochem J 310: 383-387.
    • (1995) Biochem J , vol.310 , pp. 383-387
    • Hahn, M.E.1    Karchner, S.I.2
  • 12
    • 0031262875 scopus 로고    scopus 로고
    • PAS: a multifunctional domain family comes to light
    • Ponting CP, Aravind L, (1997) PAS: a multifunctional domain family comes to light. Curr Biol 7: R674-677.
    • (1997) Curr Biol , vol.7
    • Ponting, C.P.1    Aravind, L.2
  • 13
    • 0028079988 scopus 로고
    • Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini
    • Jain S, Dolwick KM, Schmidt JV, Bradfield CA, (1994) Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini. J Biol Chem 269: 31518-31524.
    • (1994) J Biol Chem , vol.269 , pp. 31518-31524
    • Jain, S.1    Dolwick, K.M.2    Schmidt, J.V.3    Bradfield, C.A.4
  • 14
    • 0035816658 scopus 로고    scopus 로고
    • Dioxin-inducible Transactivation in a Chromosomal Setting. analysis of the acidic domain of the ah receptor
    • Jones LC, Whitlock JP Jr, (2001) Dioxin-inducible Transactivation in a Chromosomal Setting. analysis of the acidic domain of the ah receptor. J Biol Chem 276: 25037-25042.
    • (2001) J Biol Chem , vol.276 , pp. 25037-25042
    • Jones, L.C.1    Whitlock Jr., J.P.2
  • 15
    • 0035834750 scopus 로고    scopus 로고
    • The Q-rich Subdomain of the Human Ah Receptor Transactivation Domain Is Required for Dioxin-mediated Transcriptional Activity
    • Kumar MB, Ramadoss P, Reen RK, Vanden Heuvel JP, Perdew GH, (2001) The Q-rich Subdomain of the Human Ah Receptor Transactivation Domain Is Required for Dioxin-mediated Transcriptional Activity. J Biol Chem 276: 42302-42310.
    • (2001) J Biol Chem , vol.276 , pp. 42302-42310
    • Kumar, M.B.1    Ramadoss, P.2    Reen, R.K.3    Vanden Heuvel, J.P.4    Perdew, G.H.5
  • 16
    • 23944521767 scopus 로고    scopus 로고
    • The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties
    • Ramadoss P, Perdew GH, (2005) The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties. Biochemistry 44: 11148-11159.
    • (2005) Biochemistry , vol.44 , pp. 11148-11159
    • Ramadoss, P.1    Perdew, G.H.2
  • 17
    • 39749191311 scopus 로고    scopus 로고
    • The mouse and human Ah receptor differ in recognition of LXXLL motifs
    • Flaveny C, Reen RK, Kusnadi A, Perdew GH, (2008) The mouse and human Ah receptor differ in recognition of LXXLL motifs. Arch Biochem Biophys 471: 215-223.
    • (2008) Arch Biochem Biophys , vol.471 , pp. 215-223
    • Flaveny, C.1    Reen, R.K.2    Kusnadi, A.3    Perdew, G.H.4
  • 19
    • 57349174527 scopus 로고    scopus 로고
    • AHR-Mediated Downregulation of Sox9b Causes Jaw Malformation in Zebrafish Embryos
    • Xiong KM, Peterson RE, Heideman W, (2008) AHR-Mediated Downregulation of Sox9b Causes Jaw Malformation in Zebrafish Embryos. Mol Pharmacol 74: 1544-1553.
    • (2008) Mol Pharmacol , vol.74 , pp. 1544-1553
    • Xiong, K.M.1    Peterson, R.E.2    Heideman, W.3
  • 22
    • 0035834762 scopus 로고    scopus 로고
    • Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain
    • McGuire J, Okamoto K, Whitelaw ML, Tanaka H, Poellinger L, (2001) Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain. J Biol Chem 276: 41841-41849.
    • (2001) J Biol Chem , vol.276 , pp. 41841-41849
    • McGuire, J.1    Okamoto, K.2    Whitelaw, M.L.3    Tanaka, H.4    Poellinger, L.5
  • 23
    • 33845989933 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells
    • Andrysik Z, Vondracek J, Machala M, Krcmar P, Svihalkova-Sindlerova L, et al. (2007) The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells. Mutat Res 615: 87-97.
    • (2007) Mutat Res , vol.615 , pp. 87-97
    • Andrysik, Z.1    Vondracek, J.2    Machala, M.3    Krcmar, P.4    Svihalkova-Sindlerova, L.5
  • 24
    • 0031972786 scopus 로고    scopus 로고
    • Constitutive activation of the aromatic hydrocarbon receptor
    • Chang CY, Puga A, (1998) Constitutive activation of the aromatic hydrocarbon receptor. Mol Cell Biol 18: 525-535.
    • (1998) Mol Cell Biol , vol.18 , pp. 525-535
    • Chang, C.Y.1    Puga, A.2
  • 25
    • 0033579974 scopus 로고    scopus 로고
    • Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor
    • Tanguay RL, Abnet CC, Heideman W, Peterson RE, (1999) Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor. Biochim Biophys Acta 1444: 35-48.
    • (1999) Biochim Biophys Acta , vol.1444 , pp. 35-48
    • Tanguay, R.L.1    Abnet, C.C.2    Heideman, W.3    Peterson, R.E.4
  • 26
    • 0037066714 scopus 로고    scopus 로고
    • Identification of a critical amino acid in the aryl hydrocarbon receptor
    • Andreasen EA, Tanguay RL, Peterson RE, Heideman W, (2002) Identification of a critical amino acid in the aryl hydrocarbon receptor. J Biol Chem 277: 13210-13218.
    • (2002) J Biol Chem , vol.277 , pp. 13210-13218
    • Andreasen, E.A.1    Tanguay, R.L.2    Peterson, R.E.3    Heideman, W.4
  • 27
    • 26844566935 scopus 로고    scopus 로고
    • Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals
    • Garrison PM, Tullis K, Aarts JM, Brouwer A, Giesy JP, et al. (1996) Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30: 194-203.
    • (1996) Fundam Appl Toxicol , vol.30 , pp. 194-203
    • Garrison, P.M.1    Tullis, K.2    Aarts, J.M.3    Brouwer, A.4    Giesy, J.P.5
  • 28
  • 29
    • 0035205992 scopus 로고    scopus 로고
    • Disruption of erythropoiesis by dioxin in the zebrafish
    • Belair CD, Peterson RE, Heideman W, (2001) Disruption of erythropoiesis by dioxin in the zebrafish. Dev Dyn 222: 581-594.
    • (2001) Dev Dyn , vol.222 , pp. 581-594
    • Belair, C.D.1    Peterson, R.E.2    Heideman, W.3
  • 31
    • 0033591335 scopus 로고    scopus 로고
    • Two forms of aryl hydrocarbon receptor type 2 in rainbow trout (Oncorhynchus mykiss). Evidence for differential expression and enhancer specificity
    • Abnet CC, Tanguay RL, Hahn ME, Heideman W, Peterson RE, (1999) Two forms of aryl hydrocarbon receptor type 2 in rainbow trout (Oncorhynchus mykiss). Evidence for differential expression and enhancer specificity. J Biol Chem 274: 15159-15166.
    • (1999) J Biol Chem , vol.274 , pp. 15159-15166
    • Abnet, C.C.1    Tanguay, R.L.2    Hahn, M.E.3    Heideman, W.4    Peterson, R.E.5
  • 32
    • 4944256386 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in zebrafish
    • Carney SA, Peterson RE, Heideman W, (2004) 2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in zebrafish. Mol Pharmacol 66: 512-521.
    • (2004) Mol Pharmacol , vol.66 , pp. 512-521
    • Carney, S.A.1    Peterson, R.E.2    Heideman, W.3
  • 34
    • 0033567025 scopus 로고    scopus 로고
    • Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: greater insight into species differences in toxic potency of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners
    • Abnet CC, Tanguay RL, Heideman W, Peterson RE, (1999) Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: greater insight into species differences in toxic potency of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners. Toxicol Appl Pharmacol 159: 41-51.
    • (1999) Toxicol Appl Pharmacol , vol.159 , pp. 41-51
    • Abnet, C.C.1    Tanguay, R.L.2    Heideman, W.3    Peterson, R.E.4
  • 35
    • 0030245635 scopus 로고    scopus 로고
    • Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity
    • Fernandez-Salguero PM, Hilbert DM, Rudikoff S, Ward JM, Gonzalez FJ, (1996) Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharmacol 140: 173-179.
    • (1996) Toxicol Appl Pharmacol , vol.140 , pp. 173-179
    • Fernandez-Salguero, P.M.1    Hilbert, D.M.2    Rudikoff, S.3    Ward, J.M.4    Gonzalez, F.J.5
  • 36
    • 0030015421 scopus 로고    scopus 로고
    • Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development
    • Schmidt JV, Su GH, Reddy JK, Simon MC, Bradfield CA, (1996) Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci U S A 93: 6731-6736.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6731-6736
    • Schmidt, J.V.1    Su, G.H.2    Reddy, J.K.3    Simon, M.C.4    Bradfield, C.A.5
  • 37
    • 0034641727 scopus 로고    scopus 로고
    • Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice
    • Lahvis G, Lindell S, Thomas R, McCuskey R, Murphy C, et al. (2000) Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci USA 97: 10442-10447.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10442-10447
    • Lahvis, G.1    Lindell, S.2    Thomas, R.3    McCuskey, R.4    Murphy, C.5
  • 38
    • 0042027544 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia
    • Thackaberry EA, Gabaldon DM, Walker MK, Smith SM, (2002) Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia. Cardiovasc Toxicol 2: 263-274.
    • (2002) Cardiovasc Toxicol , vol.2 , pp. 263-274
    • Thackaberry, E.A.1    Gabaldon, D.M.2    Walker, M.K.3    Smith, S.M.4
  • 39
    • 0142158839 scopus 로고    scopus 로고
    • A role for the aryl hydrocarbon receptor in cardiac physiology and function as demonstrated by AhR knockout mice
    • Vasquez A, Atallah-Yunes N, Smith FC, You X, Chase SE, et al. (2003) A role for the aryl hydrocarbon receptor in cardiac physiology and function as demonstrated by AhR knockout mice. Cardiovasc Toxicol 3: 153-163.
    • (2003) Cardiovasc Toxicol , vol.3 , pp. 153-163
    • Vasquez, A.1    Atallah-Yunes, N.2    Smith, F.C.3    You, X.4    Chase, S.E.5
  • 40
    • 0023239517 scopus 로고
    • Functional inactivation of genes by dominant negative mutations
    • Herskowitz I, (1987) Functional inactivation of genes by dominant negative mutations. Nature 329: 219-222.
    • (1987) Nature , vol.329 , pp. 219-222
    • Herskowitz, I.1
  • 41
    • 33846489616 scopus 로고    scopus 로고
    • Two different transgenes to study gene silencing and re-expression during zebrafish caudal fin and retinal regeneration
    • Thummel R, Burket CT, Hyde DR, (2006) Two different transgenes to study gene silencing and re-expression during zebrafish caudal fin and retinal regeneration. ScientificWorldJournal 6 (Suppl 1): 65-81.
    • (2006) ScientificWorldJournal , vol.6 , Issue.SUPPL. 1 , pp. 65-81
    • Thummel, R.1    Burket, C.T.2    Hyde, D.R.3


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