Incidence and nature of testicular toxicity findings in pharmaceutical development

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 92, Issue 6, 2011, Pages 511-525

  Sasaki, Jennifer C ^a   Chapin, Robert E ^b   Hall, David Gregory ^c   Breslin, William ^c   Moffit, Jeffrey ^d   Saldutti, Louise ^e   Enright, Brian ^f   Seger, Monica ^g   Jarvi, Keith ^h   Hixon, Mary ⁱ   Mitchard, Terri ^j   Kim, James H ^k  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

^f ABBOTT LABORATORIES   (United States)

^g Medical and Scientific Affairs   (Canada)

^h MOUNT SINAI HOSPITAL   (Canada)

ⁱ BROWN UNIVERSITY   (United States)

^j ASTRAZENECA   (United Kingdom)

^k ILSI HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE   (United States)

more..

Author keywords

DART; Drug development; HESI; Reproductive toxicity; Testicular toxicity

Indexed keywords

AGRICULTURAL CHEMICAL; BIOLOGICAL MARKER; CHEMICAL AGENT; DOMESTIC CHEMICAL;

DRUG MANUFACTURE; DRUG SAFETY; HEALTH SURVEY; HORMONE DETERMINATION; INCIDENCE; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; REVIEW; RISK; RISK ASSESSMENT; SCREENING; SPECIES DIFFERENCE; TESTIS DISEASE; TESTIS TOXICITY;

ANIMALS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; HUMANS; MALE; PHARMACEUTICAL PREPARATIONS; TESTIS; TOXICITY TESTS;

EID: 83455226855     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20338     Document Type: Review

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