Insights into large-scale cell-culture reactors: I. Liquid mixing and oxygen supply

Biotechnology Journal

Volumn 6, Issue 12, 2011, Pages 1532-1546

  Sieblist, Christian ^a,b   Jenzsch, Marco ^b   Pohlscheidt, Michael ^b   Lübbert, Andreas ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Cell culture; Large scale bioreactors; Mixing; Oxygen mass transfer

Indexed keywords

ACCURATE MEASUREMENT; AGITATION SYSTEMS; CULTURE BROTHS; EUROPEAN MEDICINES AGENCIES; EXPERIMENTAL DATA; FLUID DYNAMIC EQUATIONS; LIQUID MIXING; MEASUREMENT TECHNIQUES; MUTUAL INTERACTION; OXYGEN MASS TRANSFER; PHARMACEUTICAL INDUSTRY; PHYSICAL MODEL; POSITION PAPERS; RECOMBINANT PROTEIN; STATE OF THE ART; STIRRED TANK REACTORS; TRANSPORT PHENOMENA;

ANIMALS; ANTIBODIES; BIOCONVERSION; BIOREACTORS; CELL CULTURE; CELLS; COMPUTATIONAL FLUID DYNAMICS; MIXING; MODELS; OXYGEN SUPPLY;

ANIMAL CELL CULTURE;

ANIMAL CELL CULTURE; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; LARGE SCALE PRODUCTION; OXYGEN SUPPLY; PHYSICAL MODEL; PRIORITY JOURNAL; STIRRED REACTOR; TURBULENT FLOW;

ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; HYDRODYNAMICS; MODELS, THEORETICAL; OXYGEN; THERMODYNAMICS;

EID: 83455225261     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201000408     Document Type: Article

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