New developments in the management of periocular capillary hemangioma in children

Journal of Pediatric Ophthalmology and Strabismus

Volumn 48, Issue 5, 2011, Pages 269-277

  Ni, Nina ^a,b   Wagner, Rudolph S ^a,b   Langer, Paul ^a,b   Guo, Suqin ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF OPHTHALMOLOGY AND VISUAL SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; ATROPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAMETHASONE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; FC RECEPTOR; GLUCOSE TRANSPORTER 1; MEROSIN; PREDNISONE; PROPRANOLOL; TESTOSTERONE 17BETA DEHYDROGENASE; TISSUE FACTOR PATHWAY INHIBITOR; TRANSCRIPTOME; TRIAMCINOLONE ACETONIDE;

AMBLYOPIA; ASTIGMATISM; BODY HEIGHT; BRADYCARDIA; BRONCHOSPASM; CANCER CHEMOTHERAPY; CAPILLARY HEMANGIOMA; CHORION VILLUS SAMPLING; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONGESTIVE HEART FAILURE; CONSERVATIVE TREATMENT; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; DRUG WITHDRAWAL; GENE EXPRESSION; HEART BLOCK; HEMANGIOMA; HUMAN; HYPOGLYCEMIA; IMMUNOTHERAPY; LONG TERM CARE; LOW DRUG DOSE; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; REVIEW; SIDE EFFECT; SPECTACLES; TREATMENT DURATION;

ANTINEOPLASTIC AGENTS; CHILD; CHILD, PRESCHOOL; EYELID NEOPLASMS; GLUCOCORTICOIDS; HEMANGIOMA, CAPILLARY; HUMANS; IMMUNOTHERAPY; INFANT; LASER THERAPY; OPHTHALMOLOGIC SURGICAL PROCEDURES; ORBITAL NEOPLASMS;

EID: 83455221181     PISSN: 01913913     EISSN: None     Source Type: Journal    
DOI: 10.3928/01913913-20110907-01     Document Type: Review

References (79)

1. Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med. 1999;341:173-181.
2. Takahashi K, Mulliken J, Kozakewich H, Rogers R, Folkman J, Ezekowitz R. Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest. 1994;93:2357-2364.
3. Slaughter K, Sullivan T, Boulton J, O'Reagan P, Gole G. Early surgical intervention as definitive treatment for ocular adnexal capillary haemangioma. Clin Exp Ophthalmol. 2003;31:418-423.
4. Mulliken J, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69:412-420.
5. Chang LC, Haggstrom AN, Drolet BA, et al. Growth characteristics of infantile hemangiomas: implications for management. Pediatrics. 2008;122:360-367.
6. Haggstrom AN, Drolet BA, Baselga E, et al. Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment. Pediatrics. 2006;118:882-887.
7. Enjolras O, Wassef M, Mazoyer E, et al. Infants with Kasabach-Merritt syndrome do not have " true" hemangiomas. J Pediatr. 1997;130:631-640.
8. Sundine MJ, Wirth GA. Hemangiomas: an overview. Clin Pediatr. 2007;46:206-221.
9. Kishnani P, Iafolla A, McConkie-Rosell A, Van Hove J, Kanter R, Kahler S. Hemangioma, supraumbilical midline raphe, and coarctation of the aorta with a right aorta arch: single causal entity? Am J Med Genet. 1995;59:44-48.
10. Bauland C, van Steensel M, Steijlen P, Rieu P, Spauwen P. The pathogenesis of hemangiomas: a review. Plast Reconstr Surg. 2006;117:29e-35e.
11. North PE, Waner M, Mizeracki A, Mihm JMC. GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol. 2000;31:11-22.
12. North PE, Waner M, Mizeracki A, et al. A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol. 2001;137:559-570.
13. Barnés CM, Huang S, Kaipainen A, et al. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Nat Acad Sci U S A. 2005;102:19097-19102.
14. Burton BK, Schulz CJ, Angle B, Burd LI. An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS). Prenatal Diagnosis. 1995;15:209-214.
15. Dadras SS, North PE, Bertoncini J, Mihm MC, Detmar M. Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol. 2004;17:1068-1079.
16. Yu Y, Flint AF, Mulliken JB, Wu JK, Bischoff J. Endothelial progenitor cells in infantile hemangioma. Blood. 2004;103:1373-1375.
17. Peralta R, Glavas I. Review of capillary hemangioma. EyeNet. 2009;Feb:35-37.
18. Enjolras O, Mulliken J. The current management of vascular birthmarks. Pediatr Dermatol. 1993;10:311-333.
19. Boyd M, Collin J. Capillary haemangiomas: an approach to their management. Br J Ophthalmol. 1991;75:298-300.
20. Schwartz SR, Blei F, Ceisler E, Steele M, Furlan L, Kodsi S. Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit. J AAPOS. 2006;10:262-268.
21. Motwani M, Simon J, Pickering J, Catalano R, Jenkins P. Steroid injection versus conservative treatment of anisometropia amblyopia in juvenile adnexal hemangioma. J Pediatr Ophthalmol Strabismus. 1995;32:26-28.
22. Tanner JL, Dechert MP, Frieden IJ. Growing up with a facial hemangioma: parent and child coping and adaptation. Pediatrics. 1998;101(3 Pt 1):446-452.
23. Gold R, O'Keefe M, Langer P. Management of capillary hemangiomas. J Pediatr Ophthalmol Strabismus. 2006;43:326-330.
24. Ceisler E, Blei F. Ophthalmic issues in hemangiomas of infancy. Lymphat Res Biol. 2003;1:321-330.
25. Haik B, Karcioglu Z, Gordon R, Pechous B. Capillary hemangioma (infantile periocular hemangioma). Surv Ophthalmol. 1994;38:399-426.
26. Weiss AH, Kelly JP. Reappraisal of astigmatism induced by periocular capillary hemangioma and treatment with intralesional corticosteroid injection. Ophthalmology. 2008;115:390-397.
27. Wasserman BN, Medow NB, Homa-Palladino M, Hoehn ME. Treatment of periocular capillary hemangiomas. J AAPOS. 2004;8:175-181.
28. Enjolras O, Claire M, Jean R, Merland J, Escande JP. Management of alarming hemangiomas in infancy: a review of 25 cases. Pediatrics. 1990;85:491-498.
29. Boon LM, MacDonald DM, Mulliken JB. Complications of systemic corticosteroid therapy for problematic hemangioma. Plast Reconstr Surg. 1999;104:1616-1623.
30. Stanbury RM, Graham EM. Systemic corticosteroid therapy: side effects and their management. Br J Ophthalmol. 1998;82:704-708.
31. Schwartz SR, Kodsi SR, Blei F, Ceisler E, Steele M, Furlan L. Treatment of capillary hemangiomas causing refractive and occlusional amblyopia. J AAPOS. 2007;11:577-583.
32. Garza G, Fay A, Rubin PA. Treatment of pediatric vascular lesions of the eyelid and orbit. Int Ophthalmol Clin. 2001;41:43-55.
33. Kushner B. Intralesional corticosteroid injection for infantile adnexal hemangioma. Am J Ophthalmol. 1982;93:496-506.
34. Morrell AJ, Willshaw HE. Normalisation of refractive error after steroid injection for adnexal haemangiomas. Br J Ophthalmol. 1991;75:301-305.
35. Cogen M, Elsas F. Eyelid depigmentation following corticosteroid injection for infantile ocular adnexal hemangioma. J Pediatr Ophthalmol Strabismus. 1989;26:35-38.
36. Sutula FC, Glover AT. Eyelid necrosis following intralesional corticosteroid injection for capillary hemangioma. Ophthalmic Surg. 1987;18:103-105.
37. Vazquez-Botet R, Reyes BA, Vazquez-Botet M. Sclerodermiform linear atrophy after the use of intralesional steroids for periorbital hemangiomas: a review of complications. J Pediatr Ophthalmol Strabismus. 1989;26:124-127.
38. Droste P, Ellis F, Sondhi N, Helveston E. Linear subcutaneous fat atrophy after corticosteroid injection of periocular hemangiomas. Am J Ophthalmol. 1988;105:65-69.
39. Weiss AH. Adrenal suppression after corticosteroid injection of periocular hemangiomas. Am J Ophthalmol. 1989;107:518-522.
40. Shorr N, Seiff S. Central retinal artery occlusion associated with periocular corticosteroid injection for juvenile hemangioma. Ophthalmic Surg. 1986;17:229-231.
41. Ruttum MS, Abrams GW, Harris GJ, Ellis MK. Bilateral retinal embolization associated with intralesional corticosteroid injection for capillary hemangioma of infancy. J Pediatr Ophthalmol Strabismus. 1993;30:4-7.
42. Kushner B, Lemke B. Bilateral retinal embolization associated with intralesional corticosteroid injection for capillary hemangioma of infancy. J Pediatr Ophthalmol Strabismus. 1993;30:397-399.
43. Elsas F, Lewis A. Topical treatment of periocular capillary hemangioma. J Pediatr Ophthalmol Strabismus. 1994;31:153-156.
44. Garzon MC, Lucky AW, Hawrot A, Frieden IJ. Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol. 2005;52:281-286.
45. Cruz OA, Zarnegar S, Myers SE. Treatment of periocular capillary hemangioma with topical clobetasol propionate. Ophthalmology. 1995;102:2012-2015.
46. Coats DK, O'Neil JW, D'Elia VJ, Brady-McCreery KM, Paysse EA. Sub Tenon's infusion of steroids for treatment of orbital hemangiomas. Ophthalmology. 2003;110:1255-1259.
47. Achauer B, Vander Kam V. Capillary hemangioma (strawberry mark) of infancy: comparison of argon and Nd:YAG laser treatment. Plast Reconstr Surg. 1989;84:60-69.
48. Korn E, Goodrich S. Use of carbon dioxide laser to remove an eyelid hemangioma. Ophthalmic Surg. 1989;20:887-888.
49. Achauer BM, Chang C-J, Vander Kam VM, Boyko A. Intralesional photocoagulation of periorbital hemangiomas. Plast Reconstr Surg. 1999;103:11-16.
50. Stier MF, Glick SA, Hirsch RJ. Laser treatment of pediatric vascular lesions: port wine stains and hemangiomas. J Am Acad Dermatol. 2008;58:261-285.
51. Waner M. Recent developments in lasers and the treatment of birthmarks. Arch Dis Child. 2003;88:372-374.
52. Waner M, Suen J, Dinehart S, Mallory S. Laser photocoagulation of superficial proliferating hemangiomas. J Dermatol Surg Oncol. 1994;20:43-46.
53. Ashinoff R, Geronemus R. Capillary hemangiomas and treatment with the flash lamp-pumped dye laser. Arch Dermatol. 1991;127:202-205.
54. Poetke M, Philipp C, Berlien H. Flashlamp-pumped pulsed dye laser for hemangiomas in infancy: treatment of superficial vs mixed hemangiomas. Arch Dermatol. 2000;136:628-632.
55. Achauer BM, Chang C-J, Vander Kam VM. Management of hemangioma of infancy: review of 245 patients. Plast Reconstr Surg. 1997;99:1301-1308.
56. Batta K, Goodyear H, Moss C, Williams H, Hiller L, Waters R. Randomised controlled study of early pulsed dye laser treatment of uncomplicated childhood haemangiomas: results of a 1-year analysis. Lancet. 2002;360:521-527.
57. Plager D, Snyder S. Resolution of astigmatism after surgical resection of capillary hemangiomas in infants. Ophthalmology. 1997;104:1102-1106.
58. Levi M, Schwartz S, Blei F, et al. Surgical treatment of capillary hemangiomas causing amblyopia. J AAPOS. 2007;11:230-234.
59. Deans R, Harris G, Kivlin JD. Surgical dissection of capillary hemangiomas: an alternative to intralesional corticosteroids. Arch Ophthalmol. 1992;110:1743-1747.
60. Arneja JS, Mulliken JB. Resection of amblyogenic periocular hemangiomas: indications and outcomes. Plast Reconstr Surg. 2010;125:274-281.
61. Tronina SA, Bobrova NF, Khrinenko VP. Combined surgical method of orbital and periorbital hemangioma treatment in infants. Orbit. 2008;27:249-257.
62. Walker R, Custer P, Nerad J. Surgical excision of periorbital capillary hemangiomas. Ophthalmology. 1994;101:1333-1340.
63. Castro R, Meek R, Bean C, Saunders D, Boudreaux IL, Witkin G. Successful treatment of a giant cavernous hemangioma with oral cyclophosphamide (cytoxan) in an infant. Del Med J. 1992;64:745-749.
64. Hurvitz SA, Hurvitz CH, Sloninsky L, Sanford MC. Successful treatment with cyclophosphamide of life-threatening diffuse hemangiomatosis involving the liver. J Pediatr Hematol Oncol. 2000;22:527-532.
65. Gottschling S, Schneider G, Meyer S, Reinhard H, Dill-Mueller D, Graf N. Two infants with life-threatening diffuse neonatal hemangiomatosis treated with cyclophosphamide. Pediatr Blood Cancer. 2006;46:239-242.
66. Ezekowitz RA, Mulliken JB, Folkman J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med. 1992;326:1456-1463.
67. Bauman NM, Burke DK, Smith RJ. Treatment of massive or life-threatening hemangiomas with recombinant alpha(2a)-interferon. Otolaryngol Head Neck Surg. 1997;117:99-110.
68. Greinwald JH Jr, Burke DK, Bonthius DJ, Bauman NM, Smith RJ. An update on the treatment of hemangiomas in children with interferon alfa-2a. Arch Otolaryngol Head Neck Surg. 1999;125:21-27.
69. Wilson MW, Hoehn ME, Haik BG, Rieman M, Reiss U. Lowdose cyclophosphamide and interferon alfa 2a for the treatment of capillary hemangioma of the orbit. Ophthalmology. 2007;114:1007-1011.
70. Leaute-Labreze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo J-B, Taieb A. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008;358:2649-2651.
71. Denoyelle F, Leboulanger N, Enjolras O, Harris R, Roger G, Garabedian E-N. Role of propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol. 2009;73:1168-1172.
72. Buckmiller LM, Munson PD, Dyamenahalli U, Dai Y, Richter GT. Propranolol for infantile hemangiomas: early experience at a tertiary vascular anomalies center. The Laryngoscope. 2010;120:676-681.
73. Sans V, de la Roque ED, Berge J, et al. Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics. 2009;124: e423-e431.
74. Guo S, Ni N. Topical treatment for capillary hemangioma of the eyelid using beta-blocker solution. Arch Ophthalmol. 2010;128:255-256.
75. Insel PA. Adrenergic receptors: evolving concepts and clinical implications. N Engl J Med. 1996;334:580-585.
76. Dishy V, Sofowora GG, Xie H-G, et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med. 2001;345:1030-1035.
77. Sommers Smith S, Smith D. Beta blockade induces apoptosis in cultured capillary endothelial cells. In Vitro Cell Dev Biol Anim. 2002;38:298-304.
78. D'Angelo G, Lee H, Weiner R. cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation. J Cell Biochem. 1997;67:353-366.
79. Siegfried EC, Keenan WJ, Al-Jureidini S, Leaute-Labreze C, de la Roque ED, Taieb A. More on propranolol for hemangiomas of infancy. N Engl J Med. 2008;359:2846-2847.