Ron receptor deficient alveolar myeloid cells exacerbate LPS-induced acute lung injury in the murine lung

Innate Immunity

Volumn 17, Issue 6, 2011, Pages 499-507

  Nikolaidis, Nikolaos M ^a   Kulkarni, Rishikesh M ^a   Gray, Jerilyn K ^a   Collins, Margaret H ^a   Waltz, Susan E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

acute lung injury; inflammation; Mst1R; Ron receptor; TNF

Indexed keywords

LIPOPOLYSACCHARIDE; PROTEIN TYROSINE KINASE; RON RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE MARKER; HISTOLOGY; HISTOPATHOLOGY; INFLAMMATION; INFLAMMATORY CELL; INNATE IMMUNITY; LUNG ALVEOLUS CELL; LUNG INJURY; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SEPSIS; SIGNAL TRANSDUCTION; WILD TYPE;

ACUTE LUNG INJURY; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; IMMUNITY, INNATE; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID CELLS; NEUTROPHILS; PULMONARY ALVEOLI; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 83455206268     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425910383725     Document Type: Article

References (24)

1. Lukacs NW, Ward PA. Inflammatory mediators, cytokines, and adhesion molecules in pulmonary inflammation and injury. Adv Immunol. 1996 ; 62: 257-304 (Pubitemid 26255263)
2. Shanley TP, Warner RL, Ward PA. The role of cytokines and adhesion molecules in the development of inflammatory injury. Mol Med Today. 1995 ; 1: 40-45
3. Strieter RM, Kunkel SL, Keane MP, Standiford TJ. Chemokines in lung injury: Thomas A. Neff Lecture. Chest. 1999 ; 116: 103S - 110S (Pubitemid 29340243)
4. Warren JS, Kunkel SL, Cunningham TW, Johnson KJ, Ward PA. Macrophage-derived cytokines amplify immune complex-triggered O2-. Responses by rat alveolar macrophages. Am J Pathol. 1988 ; 130: 489-495 (Pubitemid 18091377)
5. Worthen GS, Haslett C, Rees AJ, Gumbay RS, Henson JE, Henson PM. Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung. Am Rev Respir Dis. 1987 ; 136: 19-28 (Pubitemid 18026428)
6. Shasby DM, Vanbenthuysen KM, Tate RM, Shasby SS, McMurtry I, Repine JE. Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. Am Rev Respir Dis. 1982 ; 125: 443-447 (Pubitemid 12154490)
7. Abraham E, Carmody A, Shenkar R, Arcaroli J. Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol. 2000 ; 279: L1137 - L1145
8. Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009 ; 40: 519-535
9. Hehlgans T, Pfeffer K. The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology. 2005 ; 115: 1-20 (Pubitemid 40598088)
10. Windsor AC, Walsh CJ, Mullen PG, et al. Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation. J Clin Invest. 1993 ; 91: 1459-1468 (Pubitemid 23127347)
11. Gaudino G, Follenzi A, Naldini L, et al. Ron is a heterodimeric tyrosine kinase receptor activated by the hgf homologue msp. EMBO J. 1994 ; 13: 3524-3532 (Pubitemid 24246189)
12. Iwama A, Okano K, Sudo T, Matsuda Y, Suda T. Molecular cloning of a novel receptor tyrosine kinase gene, stk, derived from enriched hematopoietic stem cells. Blood. 1994 ; 83: 3160-3169 (Pubitemid 24158460)
13. Iwama A, Wang MH, Yamaguchi N, et al. Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the stk protein tyrosine kinase, a receptor for macrophage-stimulating protein. Blood. 1995 ; 86: 3394-3403
14. Quantin B, Schuhbaur B, Gesnel MC, Doll'e P, Breathnach R. Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development. Dev Dyn. 1995 ; 204: 383-390
15. Nikolaidis NM, Gray JK, Gurusamy D, et al. Ron receptor tyrosine kinase negatively regulates TNF-alpha production in alveolar macrophages by inhibiting NF-kappaB activity and adam17 production. Shock. 2010 ; 33: 197-204
16. Waltz SE, McDowell SA, Muraoka RS, et al. Functional characterization of domains contained in hepatocyte growth factor-like protein. J Biol Chem. 1997 ; 272: 30526-30537 (Pubitemid 27512266)
17. Lentsch AB, Pathrose P, Kader S, Kuboki S, Collins MH, Waltz SE. The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation. Shock. 2007 ; 27: 274-280
18. Waltz SE, Eaton L, Toney-Earley K, et al. Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. J Clin Invest. 2001 ; 108: 567-576 (Pubitemid 32777736)
19. Meyer SE, Zinser GM, Stuart WD, Pathrose P, Waltz SE. The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis. Dev Biol. 2009 ; 333: 173-185
20. Mallakin A, Kutcher LW, McDowell SA, et al. Gene expression profiles of mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 2006 ; 34: 15-27 (Pubitemid 43042853)
21. Clausen BE, Burkhardt C, Reith W, Renkawitz R, Forster I. Conditional gene targeting in macrophages and granulocytes using lysmcre mice. Transgenic Res. 1999 ; 8: 265-277 (Pubitemid 29523965)
22. Matute-Bello G, Frevert CW, Martin TR. Animal models of acute lung injury. Am J Physiol. 2008 ; 295: L379 - L399
23. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. 2000 ; 406: 782-787
24. Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol. 2005 ; 5: 446-458 (Pubitemid 40835033)