Thrombin inhibitor, argatroban, prevents tumor cell migration and bone metastasis

Oncology

Volumn 67, Issue 2, 2004, Pages 166-173

  Asanuma, Kunihiro ^a   Wakabayashi, Hiroki ^a   Hayashi, Tatsuya ^a   Okuyama, Noritaka ^a   Seto, Masashi ^a   Matsumine, Akihiko ^a   Kusuzaki, Katsuyuki ^a   Suzuki, Koji ^a   Uchida, Atsumasa ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Argatroban; B16 melanoma cells; Bone metastasis; Boyden chamber; Migration of tumor cells; Phagokinetic track; Thrombin; Thrombin inhibitor

Indexed keywords

ARGATROBAN; THROMBIN; THROMBIN INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE METASTASIS; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; MELANOMA CELL; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS TISSUE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTITHROMBINS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; MELANOMA, EXPERIMENTAL; MICE; PIPECOLIC ACIDS;

EID: 8344261731     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081004     Document Type: Article

References (41)

1. Magennis DP, Orchard GE: Malignant melanoma: Death by image and ignorance, diagnosis by surgical excision and laboratory investigation. Br J Biomed Sci 1999;56:134-144.
2. Lorigan JG, Wallace S, Mavligit GM: The prevalence and location of metastases from ocular melanoma: Imaging study in 110 patients. AJR Am J Roentgenol 1991;157:1279-1281.
3. Mundy GR: Mechanisms of bone metastasis. Cancer 1997;80:1546-1556.
4. Yoneda T: Cellular and molecular mechanisms of breast and prostate cancer metastasis to bone. Eur J Cancer 1998;34:240-245.
5. Hiraga T, Tanaka S, Yamamoto M, Nakajima T, Ozawa H: Inhibitory effects of bisphosphonate (YM175) on bone resorption induced by a metastatic bone tumor. Bone 1996;18:1-7.
6. Sakai T, Kisiel W: Binding of human factors X and Xa to HepG2 and J82 human tumor cell lines. Evidence that factor Xa binds to tumor cells independent of factor Va. J Biol Chem 1990;265:9105-9113.
7. Rickles FR, Edwards RL: Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood 1983;62:14-31.
8. Murray JC: Coagulation and cancer. Br J Cancer 1991;64:422-424.
9. Rao LV: Tissue factor as a tumor procoagulant. Cancer Metastasis Rev 1992;11:249-266.
10. Gordon SG: Cancer cell procoagulants and their role in malignant disease. Semin Thromb Hemost 1992;18:424-433.
11. Costantini V, Zacharski LR: Fibrin and cancer. Thromb Haemost 1993;69:406-414.
12. Kaplan KL, Francis CW: Direct thrombin inhibitors. Semin Hematol 2002;39:187-196.
13. Zain J, Huang YQ, Feng X, Nierodzik ML, Li JJ, Karpatkin S: Concentration-dependent dual effect of thrombin on impaired growth/ apoptosis or mitogenesis in tumor cells. Blood 2000;95:3133-3138.
14. Amirkhosravi A, Meyer T, Chang JY, Amaya M, Siddiqui F, Desai H, Francis JL: Tissue factor pathway inhibitor reduces experimental lung metastasis of B16 melanoma. Thromb Haemost 2002;87:930-936.
15. Suzuki K, Nishioka J, Hayashi T: Localization of thrombomodulin-binding site within human thrombin. J Biol Chem 1990;265:13263-13267.
16. Bernatowicz MS, Klimas CE, Hartl KS, Peluso M, Allegretto NJ, Seiler SM: Development of potent thrombin receptor antagonist peptides. J Med Chem 1996;39:4879-4887.
17. Albrecht-Buehler G: The phagokinetic tracks of 3T3 cells. Cell 1977;11:395-404.
18. Zhou H, Gabazza EC, Takeya H, Deguchi H, Urano H, Adachi Y, Suzuki K: Prothrombin and its derivatives stimulate motility of melanoma cells. Thromb Haemost 1998;80:407-412.
19. Wakabayashi H, Hibasami H, Iida K, Satoh N, Yamazaki T, Sonoda J, Hirata H, Nakashima K, Uchida A: Prevention of metastasis by a polyamine synthesis inhibitor in an animal bone metastasis model. Oncology 2000;59:75-80.
20. Wojtukiewicz MZ, Sierko E, Zacharski LR, Zimnoch L, Kudryk B, Kisiel W: Tissue factordependent coagulation activation and impaired fibrinolysis in situ in gastric cancer. Semin Thromb Hemost 2003;29:291-300.
21. Rickles FR, Shoji M, Abe K: The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: Tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer. Int J Hematol 2001;73:145-150.
22. Seto S, Onodera H, Kaido T, Yoshikawa A, Ishigami S, Arii S, Imamura M: Tissue factor expression in human colorectal carcinoma: Correlation with hepatic metastasis and impact on prognosis. Cancer 2000;88:295-301.
23. Poon RT, Lau CP, Ho JW, Yu WC, Fan ST, Wong J: Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res 2003;9:5339-5345.
24. Forster Y, Meye A, Albrecht S, Kotzsch M, Fussel S, Wirth MP, Schwenzer B: Tissue specific expression and serum levels of human tissue factor in patients with urological cancer. Cancer Lett 2003;193:65-73.
25. Chen LB, Buchanan JM: Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci USA 1975;72:131-135.
26. Carney DH, Glenn KC, Cunningham DD: Conditions which affect initiation of animal cell division by trypsin and thrombin. J Cell Physiol 1978;95:13-22.
27. Glenn KC, Carney DH, Fenton JW 2nd, Cunningham DD: Thrombin active site regions required for fibroblast receptor binding and initiation of cell division. J Biol Chem 1980; 255:6609-6616.
28. Carney DH, Stiernberg J, Fenton JW 2nd: Initiation of proliferative events by human alphathrombin requires both receptor binding and enzymic activity. J Cell Biochem 1984;26:181-195.
29. Morris DL, Ward JB Jr, Nechay P, Whorton EB Jr, Fenton JW 2nd, Carney DH: Highly purified human alpha-thrombin promotes morphological transformation of BALB/c 3T3 cells. Carcinogenesis 1992;13:1-7.
30. McNamara CA, Sarembock IJ, Gimple LW, Fenton JW 2nd, Coughlin SR, Owens GK: Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 1993;91:94-98.
31. Nierodzik ML, Kajumo F, Karpatkin S: Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res 1992;52:3267-3272.
32. Nierodzik ML, Plotkin A, Kajumo F, Karpatkin S: Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo. J Clin Invest 1991;87:229-236.
33. Klepfish A, Greco MA, Karpatkin S: Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix. Int J Cancer 1993;53:978-982.
34. Yamamoto N, Greco NJ, Barnard MR, Tanoue K, Yamazaki H, Jamieson GA, Michelson AD: Glycoprotein Ib (GPIb)-dependent and GPIbindependent pathways of thrombin-induced platelet activation. Blood 1991;77:1740-1748.
35. Gralnick HR, Williams S, McKeown LP, Hansmann K, Fenton JW 2nd, Krutzsch H: High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: Identification of two binding domains. Proc Natl Acad Sci USA 1994;91:6334-6338.
36. Rasmussen UB, Vouret-Craviari V, Jallat S, Schlesinger Y, Pages G, Pavirani A, Lecocq JP, Pouyssegur J, Van Obberghen-Schilling E: cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett 1991;288:123-128.
37. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR: Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997;386:502-506.
38. Wojtukiewicz MZ, Tang DG, Nelson KK, Walz DA, Diglio CA, Honn KV: Thrombin enhances tumor cell adhesive and metastatic properties via increased alpha IIb beta 3 expression on the cell surface. Thromb Res 1992;68:233-245.
39. Esumi N, Fan D, Fidler IJ: Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. Cancer Res 1991;51:4549-4556.
40. Perez M, Migliaccio S, Taranta A, Festuccia C, Orru L, Brama M, Bologna M, Faraggiana T, Baron R, Teti A: Melanoma cells stimulate osteoclastogenesis, c-Src expression and osteoblast cytokines. Eur J Cancer 2001;37:629-640.
41. Abraham LA, Jenkins AL, Stone SR, Mackie EJ: Expression of the thrombin receptor in developing bone and associated tissues. J Bone Miner Res 1998;13:818-827.