The pathophysiology of irritable bowel syndrome

Minerva Medica

Volumn 95, Issue 5, 2004, Pages 419-426

  Schwetz, I ^a,b   Bradesi, S ^a   Mayer, E A ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Colonic diseases, functional, diagnosis; Colonic diseases, functional, physiopathology; Colonic diseases, functional, therapy

Indexed keywords

ABDOMINAL PAIN; CHRONIC INFLAMMATION; IMMUNE RESPONSE; IRRITABLE COLON; MUCOSAL IMMUNITY; NEUROIMAGING; PAIN; PATHOPHYSIOLOGY; REVIEW; STIMULATION; VISCERAL HYPERSENSITIVITY; VISCERAL STIMULATION;

EID: 8344251723     PISSN: 00264806     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (59)

1. Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology 2002;123:2108-31.
2. Mayer EA, Collins SM. Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology 2002;122:2032-48.
3. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994;107:271-93.
4. Bennett EJ, Tennant CC, Piesse C, Badcock CA, Kellow JE. Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut 1998;43:256-61.
5. Collins SM. A case for an immunological basis for irritable bowel syndrome. Gastroenterology 2002;122:2078-80.
6. Gwee KA, Graham JC, McKendrick MW, Collins SM, Marshall JS, Walters SJ et al. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet 1996;347:150-3.
7. Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, Walters SJ et al. The role of psychological and biological factors in postinfective gut dysfunction. Gut 1999;44:400-6.
8. Chadwick VS, Chen W, Shu D, Paulus B, Bethwaite P, Tie A et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002;122:1778-83.
9. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M et al. Increased rectal mucosal enteroendocrine cells, T-lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000;47:804-11.
10. Tornblom H, Lindberg G, Nyberg B, Veress B. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002;123:1972-9.
11. Barbara G, De Giorgio R, Deng Y, Vallance BA, Blennerhassett P, Collins SM. Role of immunological factors and cyclooxygenase-2 in persistent post infective enteric muscle dysfunction in mice. Gastroenterology 2001;120:1729-36.
12. De Giorgio R, Barbara G, Blennerhassett P, Wang L, Stanghellini V, Corinaldesi R et al. Intestinal inflammation and activation of sensory nerve pathways: a functional and morphological study in the nematode-infected rat. Gut 2001;49:822-7.
13. Naliboff BD, Derbyshire SWG, Munakata J, Berman S, Mandelkern M, Chang L et al. Cerebral activation in irritable bowel syndrome patients and control subjects during rectosigmoid stimulation. Psychosom Med 2001;63:365-75.
14. Mertz H, Morgan V, Tanner G, Pickens D, Price R, Shyr Y et al. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and non-painful rectal distension. Gastroenterology 2000;118:842-8.
15. Bonaz B, Baciu M, Papillon E, Bost R, Gueddah N, Le Bas JF et al. Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study. Am J Gastroenterol 2002;97:654-61.
16. Coutinho SV, Plotsky PM, Sablad M, Miller JC, Zhou H, Bayati AI et al. Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol 2002;282:G307-16.
17. Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995;109:40-52.
18. Bouin M, Plourde V, Boivin M, Riberdy M, Lupien F, Laganiere M et al. Rectal distension testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology 2002;122:1771-7.
19. Chang L, Munakata J, Mayer EA, Schmulson MJ, Johnson TD, Bernstein CN et al. Perceptual responses in patients with inflammatory and functional bowel disease. Gut 2000;47:497-505.
20. Loening-Baucke V, Metcalf AM, Shirazi S. Anorectal manometry in active and quiescent ulcerative colitis. Am J Gastroenterol 1989;84:892-7.
21. Rao SSC, Read NW, Davison PA, Bannister JJ, Holdsworth CD. Anorectal sensitivity and responses to rectal distention in patients with ulcerative colitis. Gastroenterology 1987;93:1270-5.
22. Fass R, Naliboff B, Higa L, Johnson C, Kodner A, Munakata J et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998;115:1363-73.
23. Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998;42:814-22.
24. Chang L, Mayer EA, Johnson T, FitzGerald L, Naliboff B. Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia. Pain 2000;84:297-307.
25. Neal KR, Hebden J, Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. BMJ 1997;314:779-82.
26. Bergin AJ, Read NW. The effect of preliminary bowel preparation on a simple test of colonic transit in constipated subjects. Int J Colorect Dis 1993;8:75-7.
27. Isgar B, Harman M, Kaye MD, Whorwhell PJ. Symptoms of irritable bowel syndrome in ulcerative colitis in remission. Gut 1983;24:190-2.
28. Simren M, Axelsson J, Abrahamsson H, Svedlund J, Bjsrnsson ES. Symptoms of irritable bowel syndrome in inflammatory bowel disease in remission and relationship to psychological factors. Gastroenterology 2000;118:A702.
29. Annese V, Bassotti G, Napolitano G, Usai P, Andriulli A, Vantrappen G. Gastrointestinal motility disorders in patients with inactive Crohn's disease. Scand J Gastroenterol 1997;32:1107-17.
30. Bernstein CN, Niazi N, Robert M, Mertz H, Kodner A, Munakata J et al. Rectal afferent function in patients with inflammatory and functional intestinal disorders. Pain 1996;66:151-61.
31. Tibble JA, Sigthorsson G, Foster R, Forgacs I, Bjarnason I. Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease. Gastroenterology 2002;123:450-60.
32. Chan J, Gonsalkorale WM, Perrey C, Previca V, Hajeer AH, Whorwell PJ et al. I1-10 and Tgf-b genotypes in irritable bowel syndrome: evidence to support an inflammatory component? Gastroenterology 2000;118:A184.
33. Vallance B, Blennerhassett PA, Deng Y, Matthaei KI, Young IG, Collins SM. IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection. Am J Physiol 1999;277:G400-8.
34. Galeazzi F, Haapala EM, van Rooijen N, Vallance BA, Collins SM. Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. Am J Physiol Gastrointest Liver Physiol 2000;278:G259-65.
35. Der T, Bercik P, Donnelly G, Jackson T, Berezin I, Collins SM et al. Interstitial cells of cajal and inflammation-induced motor dysfunction in the mouse small intestine. Gastroenterology 2000;119:1590-9.
36. Barbara G, Vallance BA, Collins SM. Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice. Gastroenterology 1997;113:1224-32.
37. Vallance BA, Blennerhassett PA, Collins SM. Increased intestinal muscle contractility and worm expulsion in nematode-infected mice. Am J Physiol 1997;272:G321-7.
38. Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut 2000;47:861-9.
39. Mayer EA, Naliboff BD, Chang L, Coutinho SV. Stress and the gastrointestinal tract: V. Stress and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2001;280:G519-24.
40. Matthews SG. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol Metab 2002;13:373-80.
41. Ladd CO, Huot RL, Thrivikraman KV, Nemeroff CB, Meaney MJ, Plotsky P. Long-term behavioral and neuroendocrine adaptations to adverse early experience. In: Mayer EA, Saper CB. editors. The biological basis for mind body interactions. Amsterdam: Elsevier: 2000.p. 81-103.
42. Fuchs E, Fluegge G. Modulation of binding sites for corticotropin- releasing hormone by chronic psychosocial stress. Psychoneuroendocrinology 1995;20:33-51.
43. Heim C, Ehlert U, Hellhammer DH. The potential role of hypercortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 2000;25:1-35.
44. Whitehead M, Holland P. What puts children of lone parents at a health disadvantage? Lancet 2003;361:271.
45. Lowman BC, Drossman DA, Cramer EM, McKee DC. Recollection of childhood events in adults with irritable bowel syndrome. J Clin Gastroenterol 1987;9:324-30.
46. Petrovic P, Ingvar M. Imaging cognitive modulation of pain processing. Pain 2002;95:1-5.
47. Bandler R, Keay KA. Columnar organization in the midbrain periaqueductal gray and the integration of emotional expression. In: Holstege G, Bandler R, Saper CB, editors The emotional motor system. Progress in brain research. Amsterdam: Elsevier; 1996.p.285-300.
48. Zhuo M, Gebhart GF. Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat. Gastroenterology 2002;122:1007-19.
49. Porreca F, Ossipov MH, Gebhart GF. Chronic pain and medullary descending facilitation. Trends Neurosci 2002;25:319-25.
50. Mertz H. Role of the brain and sensory pathways in gastrointestinal sensory disorders in humans. Gut 2002;51:i29-i33.
51. Chang L, Berman S, Mayer EA, Suyenobu B, Derbyshire S, Naliboff B et al. Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgia. Am J Gastroenterol 2003;98:1354-61.
52. Kalinichev M, Easterling KW, Plotsky PM, Holtzman SG. Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats. Pharmacol Biochem Behav 2002;73:131-40.
53. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 1999;160:1-12.
54. Caldji C, Francis D, Sharma S, Plotsky PM, Meaney MJ. The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology 2000;22:219-29.
55. Soderholm JD, Yates DA, Gareau MG, Yang PC, MacQueen G, Perdue MH. Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress. Am J Physiol Gastrointest Liver Physiol 2002;283:G1257-63.
56. Taché Y, Martinez V, Million M, Wang L. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol 2001;280:G173-7.
57. Watkins LR, Wiertelak EP, Goehler LE, Mooney-Heiberger K, Martinez J, Furness L et al. Neurocircuitry of illness-induced hyoeralgesia. Brain Res 1994;639:283-99.
58. Maier SF, Watkins LR. Cytokines for psychologists: implications and bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 1998;105:83-107.
59. Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead WE. ROME II. The functional gastrointestinal disorders. Diagnosis, pathophysiology and treatment: a multinational consensus. McLean, VA: Degnon Associates; 2000.