Interleukin-10 promoter microsatellite polymorphisms in systemic lupus erythematosus: Association with the anti-Sm immune response

Rheumatology

Volumn 43, Issue 11, 2004, Pages 1357-1363

  Schotte, H ^a   Gaubitz, M ^a   Willeke, P ^a   Tidow, N ^a   Assmann, G ^a   Domschke, W ^a   Schluter B ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Anti Sm antibodies; German Caucasian patients; Interleukin 10; Promoter microsatellite polymorphisms; Systemic lupus erythematosus

Indexed keywords

INTERLEUKIN 10; MICROSATELLITE DNA;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BAYES THEOREM; CAUCASIAN; CHILD; CLINICAL FEATURE; COMPUTER PROGRAM; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ETHNIC DIFFERENCE; FEMALE; GENE DOSAGE; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GERMANY; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IN VITRO STUDY; INDIVIDUALIZATION; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ADULT; AGED; ALLELES; AUTOANTIBODIES; AUTOANTIGENS; CHILD; CHILD, PRESCHOOL; FEMALE; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INTERLEUKIN-10; LINKAGE DISEQUILIBRIUM; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RIBONUCLEOPROTEINS, SMALL NUCLEAR;

EID: 8344242991     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keh353     Document Type: Article

References (43)

1. Mok CC, Lau CS. Pathogenesis of systemic lupus erythematosus. J Clin Pathol 2003;56:481-90.
2. Prokunina L, Alarcon-Riquelme M. The genetic basis of systemic lupus erythematosus - knowledge of today and thoughts for tomorrow. Hum Mol Genet 2004;13:R143-R148.
3. Fiorentino DF, Zlotnik A, Vieira P et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991;146:3444-51.
4. Wanidworanun C, Strober W. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. J Immunol 1993; 151:6853-61.
5. Rousset F, Garcia E, Defrance T et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992;89:1890-3.
6. de Waal Malefyt R, Yssel H, de Vries JE. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J Immunol 1993;150: 4754-65.
7. Llorente L, Richaud-Patin Y, Wijdenes J et al. Spontaneous production of interieukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus. Eur Cytokine Netw 1993;4:421-7.
8. Llorente L, Richaud-Patin Y, Fior R et al. In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. A potential mechanism of B lymphocyte hyperactivity and autoimmunity. Arthritis Rheum 1994;37:1647-55.
9. Llorente L, Zou W, Levy Y et al. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 1995;181:839-44.
10. Horwitz DA, Gray JD, Behrendsen SC et al. Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus. Arthritis Rheum 1998;41:838-44.
11. Houssiau FA, Lefebvre C, Vanden Berghe M, Lambert M, Devogelaer JP, Renauld JC. Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity. Lupus 1995;4:393-5.
12. Hagiwara E, Gourley MF, Lee S, Klinman DK. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10: interferon-gamma-secreting cells in the peripheral blood. Arthritis Rheum 1996;39:379-85.
13. Lacki JK, Samborski W, Mackiewicz SH. Interleukin-10 and interleukin-6 in lupus erythematosus and rheumatoid arthritis, correlations with acute phase proteins. Clin Rheumatol 1997;16: 275-8.
14. Park YB, Lee SK, Kim DS, Lee J, Lee CH, Song CH. Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus. Clin Exp Rheumatol 1998;16:283-8.
15. Llorente L, Richaud-Patin Y, Garcia-Padilla C et al. Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus. Arthritis Rheum 2000;43:1790-800.
16. Miles S, Isenberg D. A review of serological abnormalities in relatives of SLE patients. Lupus 1993;2:145-50.
17. Llorente L, Richaud-Patin Y, Couderc J et al. Dysregulation of interleukin-10 production in relatives of patients with systemic lupus erythematosus. Arthritis Rheum 1997;40:1429-35.
18. Llorente L, Richaud-Patin Y. The role of interleukin-10 in systemic lupus erythematosus. J Autoimmun 2003;20:287-9.
19. Westendorp RG, Langermans JA, Huizinga TW et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349:170-3.
20. Eskdale J, Kube D, Tesch H, Gallagher G. Mapping of the human IL10 gene and further characterization of the 5′ flanking sequence. Immunogenetics 1997;46:120-8.
21. Eskdale J, Gallagher G. A polymorphic dinucleotide repeat in the human IL-10 promoter. Immunogenetics 1995;42:444-5.
22. Eskdale J, Kube D, Gallagher G. A second polymorphic dinucleotide repeat in the 5′ flanking region of the human IL10 gene. Immunogenetics 1996;45:82-3.
23. Eskdale J, Gallagher G, Verweij CL, Keijsers V, Westendorp RG, Huizinga TW. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA 1998;95:9465-70.
24. Eskdale J, Wordsworth P, Bowman S, Field M, Gallagher G. Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus. Tissue Antigens 1997;49:635-9.
25. Mehrian R, Quismorio FP Jr, Strassmann G et al. Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus. Arthritis Rheum 1998;41: 596-602.
26. Alarcon-Riquelme ME, Lindqvist AK, Jonasson I et al. Genetic analysis of the contribution of IL10 to systemic lupus erythematosus. J Rheumatol 1999;26:2148-52.
27. D'Alfonso S, Rampi M, Bocchio D, Colombo G, Scorza-Smeraldi R, Momigliano-Richardi P. Systemic lupus erythematosus candidate genes in the Italian population: evidence for a significant association with interleukin-10. Arthritis Rheum 2000;43:120-8.
28. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
29. Assmann G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Munster study. Am J Cardiol 1992;70:733-7.
30. Higuchi R. Simple and rapid preparation of samples for PCR. In: Ehrlich HA (ed.) PCR-Technology, Principles and Applications for DNA Amplification. New York: Stockton Press, 1989:31-8.
31. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001;68:978-89.
32. Stephens M, Donnelly P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003;73:1162-9.
33. Sham PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 1995;59:97-105.
34. D'Alfonso S, Giordano M, Mellai M et al. Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region. Genes Immun 2002;3:454-63.
35. Grondal G, Kristjansdottir H, Gunnlaugsdottir B et al. Increased number of interleukin-10-producing cells in systemic lupus erythematosus patients and their first-degree relatives and spouses in Icelandic multicase families. Arthritis Rheum 1999;42:1649-54.
36. Grondal G, Traustadottir KH, Kristjansdottir H et al. Increased T-lymphocyte apoptosis/necrosis and IL-10 producing cells in patients and their spouses in Icelandic systemic lupus erythematosus multicase families. Lupus 2002;11:435-42.
37. Lazarus M, Hajeer AH, Turner D et al. Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. J Rheumatol 1997;24:2314-17.
38. Mok CC, Lanchbury JS, Chan DW, Lau CS. Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus. Arthritis Rheum 1998;41:1090-5.
39. Rood MJ, Keijsers V, van der Linden MW et al. Neuropsychiatric systemic lupus erythematosus is associated with imbalance in interleukin 10 promoter haplotypes. Ann Rheum Dis 1999;58:85-9.
40. Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP. Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol 2001;166:3915-22.
41. Eskdale J, Keijsers V, Huizinga T, Gallagher G. Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus. Genes Immun 1999;1:151-5.
42. Zieve GW, Khusial PR. The anti-Sm immune response in autoimmunity and cell biology. Autoimmun Rev 2003;2:235-40.
43. Kalechman Y, Gafter U, Da JP, Albeck M, Alarcon-Segovia D, Sredni B. Delay in the onset of systemic lupus erythematosus following treatment with the immunomodulator AS101: association with IL-10 inhibition and increase in TNF-alpha levels. J Immunol 1997;159:2658-67.