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Volumn 11, Issue 1, 2011, Pages

The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; PHOSPHATE; DRUG VEHICLE; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 83355164013     PISSN: None     EISSN: 14712210     Source Type: Journal    
DOI: 10.1186/1471-2210-11-12     Document Type: Article
Times cited : (21)

References (15)
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    • Microneedles: A Valuable Physical Enhancer to Increase Transdermal Drug Delivery. J Clin Pharmacol . Table 2 Skin permeation parameters Formulation Recovery (%) Jmax (μ g/cm2/h) Lagtime (h) Skin absorption (μ g/cm2) Ibutop® gel 21 ± 5a 50 ± 23 0.0 ± 0.2ac 239 ± 159 Ibutop® cream 59 ± 8 65 ± 15 1.3 ± 0.6 57 ± 25 Ibuprofen solution 26 ± 8b 42 ± 16 1.3 ± 0.8 264 ± 192 Absorption parameters of bovine udder skin (recovery in the receptor chamber, Jmax, lagtime, and skin absorption) following application of different topical formulations containing ibuprofen 5%; n = 5-6, mean and standard deviation; p < 0.05 (One-way ANOVA followed by Tukey's multiple comparison test; a: gel vs. cream, b: solution vs. cream, c: gel vs. solution) Stahl et al.
    • Escobar-Chavez JJ, Bonilla-Martinez D, Villegas-Gonzalez MA, Molina-Trinidad E, Casas-Alancaster N, Revilla-Vazquez AL: Microneedles: A Valuable Physical Enhancer to Increase Transdermal Drug Delivery. J Clin Pharmacol . Table 2 Skin permeation parameters Formulation Recovery (%) Jmax (μ g/cm2/h) Lagtime (h) Skin absorption (μ g/cm2) Ibutop® gel 21 ± 5a 50 ± 23 0.0 ± 0.2ac 239 ± 159 Ibutop® cream 59 ± 8 65 ± 15 1.3 ± 0.6 57 ± 25 Ibuprofen solution 26 ± 8b 42 ± 16 1.3 ± 0.8 264 ± 192 Absorption parameters of bovine udder skin (recovery in the receptor chamber, Jmax, lagtime, and skin absorption) following application of different topical formulations containing ibuprofen 5%; n = 5-6, mean and standard deviation; p < 0.05 (One-way ANOVA followed by Tukey's multiple comparison test; a: gel vs. cream, b: solution vs. cream, c: gel vs. solution) Stahl et al. BMC Pharmacology 2011, 11:12 http://www.biomedcentral.com/1471-2210/11/12
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.