Epoxyquinone formation catalyzed by a two-component flavin-dependent monooxygenase involved in biosynthesis of the antibiotic actinorhodin

ChemBioChem

Volumn 12, Issue 18, 2011, Pages 2767-2773

  Taguchi, Takaaki ^a   Okamoto, Susumu ^a,b   Hasegawa, Kimiko ^c   Ichinose, Koji ^a  

^a MUSASHINO UNIVERSITY   (Japan)

^b NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^c RIGAKU CORPORATION   (Japan)

Author keywords

Actinorhodin; Antibiotics; Biosynthesis; Epoxyquinones; Oxidoreductases; Streptomyces coelicolor

Indexed keywords

ACTINORHODINE; DIHYDROKALAFUNGIN; ENZYME; EPOXYKALAFUNGIN; FLAVIN DEPENDENT MONOOXYGENASE; GRISEOFULVIN; KALAFUNGIN; QUERCETIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ACTINOBACTERIA; ARTICLE; BIOSYNTHESIS; CHEMICAL ANALYSIS; EPOXIDATION; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGENATION; PRIORITY JOURNAL; STREPTOMYCES COELICOLOR; X RAY CRYSTALLOGRAPHY;

ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; EPOXY COMPOUNDS; FLAVINS; MAGNETIC RESONANCE SPECTROSCOPY; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; QUINONES;

EID: 83355160738     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201100571     Document Type: Article

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