Effects of a 28-day cage-change interval on intracage ammonia levels, nasal histology, and perceived welfare of CD1 mice

Journal of the American Association for Laboratory Animal Science

Volumn 50, Issue 6, 2011, Pages 868-878

  Vogelweid, Catherine M ^a,b   Zapien, Kathleen A ^a   Honigford, Matthew J ^a   Li, Linghui ^a   Li, Hua ^a   Marshall, Heather ^a  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA;

ANIMAL CARE; ANIMAL EXPERIMENT; ANIMAL HOUSING; ARTICLE; CAGE; EXPERIMENTAL ANIMAL WELFARE; EXPOSURE; FEMALE; HISTOPATHOLOGY; INFLAMMATION; MALE; MOUSE; MUCOSAL NECROSIS; NONHUMAN; NOSE MUCOSA; OLFACTORY EPITHELIUM; RHINITIS;

AIR POLLUTION, INDOOR; AMMONIA; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, LABORATORY; DISPOSABLE EQUIPMENT; FEMALE; HOUSING, ANIMAL; MALE; MICE; NECROSIS; OLFACTORY MUCOSA; TIME FACTORS;

EID: 83255187432     PISSN: 15596109     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Bolon B, Bonnefoi MS, Roberts KC, Marshall MW, Morgan KT. 1991. Toxic interactions in the rat nose: pollutants from soiled bedding and methyl bromide. Toxicol Pathol 19:571-579.
2. Drickamer LC. 1995. Rates of urine excretion by house mouse (Mus domesticus): differences by age, sex, social status, and reproductive condition. J Chem Ecol 21:1481-1493. (Pubitemid 3018119)
3. Fitchett AE, Barnard CJ, Cassaday HJ. 2006. There's no place like home: cage odours and place preference in subordinate CD1 male mice. Physiol Behav 87:955-962.
4. Fox JG, Anderson LC, Lowe FM, Quimby FW, editors. 2002. Biology and diseases of mice, chapter 3. In: Laboratory animal medicine, 2nd ed. San Diego (CA): Academic Press.
5. Gamble MR, Clough G. 1976. Ammonia build-up in animal boxes and its effect of rat tracheal epithelium. Lab Anim 10:93-104.
6. Green AR, Wathes CM, Demmers TGM, MacArthur Clark J, Xin H. 2008. Development and application of a novel environmental preference chamber for assessing responses of laboratory mice to atmospheric ammonia. J Am Assoc Lab Anim Sci 47:49-56. (Pubitemid 351498149)
7. Hardisty JF, Garman RH, Harkema JR, Lomax LG, Morgan KT. 1999. Histopathology of nasal olfactory mucosa from selected inhalation toxicology studies conducted with volatile chemicals. Toxicol Pathol 27:618-627.
8. Harkema JR. 1990. Comparative pathology of the nasal mucosa in laboratory animals exposed to inhaled irritants. Environ Health Perspect 85:231-238. (Pubitemid 20315302)
9. Harkema JR, Carey SA, Wagner JG. 2006. The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium. Toxicol Pathol 34:252-269.
10. Institute for Laboratory Animal Research. 2010. Guide for the care and use of laboratory animals, 8th ed. Chapter 3: environment, housing, and management, p 41-77. Washington (DC): National Academies Press.
11. Mery S, Gross EA, Joyner DR, Godo M, Morgan KT. 1994. Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice. Toxicol Pathol 22:353-372. (Pubitemid 24314247)
12. Morgan KT. 1991. Approaches to the identification and recording of nasal lesions in toxicology studies. Toxicol Pathol 19:337-351.
13. Piechowiak M. [Internet]. 2010. Adopting disposable caging: case study of breeding results. [Cited June 2010]. Available at: http://www.alnmag.com/ article/adopting-disposable-caging-case-study-breeding-results.
14. Pinson DM, Schoeb TR, Lindsey JR, Davis JK. 1986. Evaluation by scoring and computerized morphometry of lesions of early Mycoplasma pulmonis infection and ammonia exposure in F344/N rats. Vet Pathol 23:550-555.
15. Popp JA, Monteiro-Riviere NA. 1985. Macroscopic, microscopic, and ultrastructural anatomy of the nasal cavity, rat, p 3-10. In: Jones TC, Mohr U, Hunt RD, editors. Monographs on pathology of laboratory animals, respiratory system. New York (NY): Springer-Verlag.
16. Reeb-Whitaker CK, Paigen B, Beamer WG, Bronson RT, Churchill GA, Schweitzer IB, Myers DD. 2001. The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages. Lab Anim 35:58-73. (Pubitemid 32061606)
17. Renne RA, Dungworth DL, Keenan CM, Morgan KT, Hahn FF, Schwartz LW. 2003. Nonproliferative lesions of the respiratory tract in rats, R1, p 1-26. In: Guides for toxicologic pathology. Society of Toxicologic Pathologists/Armed Forces Institute of Pathology. Washington (DC): Society of Toxicologic Pathologists.
18. Rosenbaum MD, VandeWoude S, Johnson TE. 2009. Effects of cage-change frequency and bedding volume on mice and their microenvironment. J Am Assoc Lab Anim Sci 48:763-773.
19. Rosenbaum MD, VandeWoude S, Volckens J, Johnson TE. 2010. Disparities in ammonia, temperature, humidity, and airborne particulate matter between micro- and macroenvironments of mice in individually ventilated caging. J Am Assoc Lab Anim Sci 49:177-183.
20. Silverman J, Bays DW, Baker SP. 2009. Ammonia and carbon dioxide concentrations in disposable and reusable static mouse cages. Lab Anim (NY) 38:16-23.
21. Silverman J, Bays DW, Cooper SF, Baker SP. 2008. Ammonia and carbon dioxide concentrations in disposable and reusable ventilated mouse cages. J Am Assoc Lab Anim Sci 47:57-62. (Pubitemid 351498150)
22. Stechman MJ, Ahmad BN, Loh NY, Reed AA, Stewart M, Wells S, Hough T, Bentley L, Cox RD, Brown SDM, Thakker RJ. 2010. Establishing normal plasma and 24-hour urinary biochemistry ranges in C3H, BALB/c and C57BL/6J mice following acclimatization in metabolic cages. Lab Anim 44:218-225.
23. Uraih LC, Maronpot RR. 1990. Normal histology of the nasal cavity and application of special techniques. Environ Health Perspect 85:187-208. (Pubitemid 20315299)