Disparities in ammonia, temperature, humidity, and airborne particulate matter between the micro-and macroenvironments of mice in individually ventilated caging

Journal of the American Association for Laboratory Animal Science

Volumn 49, Issue 2, 2010, Pages 177-183

  Rosenbaum, Matthew D ^a   VandeWoude, Susan ^b   Volckens, John ^b   Johnson, Thomas E ^b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA;

AEROSOL; AIRBORNE PARTICLE; AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL WELFARE; ARTICLE; CAGE; CHEMICAL WASTE; CONCENTRATION PROCESS; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; HUMIDITY; ISOLATION PROCEDURE; MICROENVIRONMENT; MOUSE; NONHUMAN; PARTICULATE MATTER; PRACTICE GUIDELINE; ROOM TEMPERATURE; ROOM VENTILATION;

AMMONIA; ANIMALS; ENVIRONMENT; FEMALE; HOUSING, ANIMAL; HUMIDITY; MICE; MICE, INBRED ICR; PARTICULATE MATTER; TEMPERATURE; VENTILATION;

ANIMALIA; MUS;

EID: 77950611308     PISSN: 15596109     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. American Conference of Governmental Industrial Hygienists. 2007 Threshold limit values (TLVs) and biological exposure indices (BEI). Cincinnati (OH): ACGIH.
2. Baumans V, Schlingmann F, Vonck M, van Lith HA. 2002. Individually ventilated cages: beneficial for mice and men? Contemp Top Lab Anim Sci 41:13-19.
3. Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI. 2004. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77:347-357. (Pubitemid 38262608)
4. Bland SM, Levine MS, Wilson PD, Fox NL, Rivera JC. 1986. Occupational allergy to laboratory animals: an epidemiologic study. J Occup Med 28:1151-1157. (Pubitemid 17193191)
5. Burn CC, Deacon RM, Mason GJ. 2008. Marked for life? Effects of early cage-cleaning frequency, delivery batch, and identification tail-marking on rat anxiety profiles. Dev Psychobiol 50:266-277.
6. Bush RK, Stave GM. 2003. Laboratory animal allergy: an update. ILAR J 44:28-51.
7. Dillehay DL, Lehner ND, Huerkamp MJ. 1990. The effectiveness of a microisolator cage system and sentinel mice for controlling and detecting MHV and Sendai virus infections. Lab Anim Sci 40:367-370.
8. Dockery DW. 2009. Health effects of particulate air pollution. Ann Epidemiol 19:257-263.
9. Eggleston PA, Newill CA, Ansari AA, Pustelnik A, Lou SR, Evans R 3rd, Marsh DG, Longbottom JL, Corn M. 1989. Task-related variation in airborne concentrations of laboratory animal allergens: studies with rat n I. J Allergy Clin Immunol 84:347-352.
10. Fox JG, Anderson LC, Loew FM, Quimby FW, editors. 2002. Laboratory animal medicine, 2nd ed. New York (NY): Academic Press.
11. Gamble MR, Clough G. 1976. Ammonia build-up in animal boxes and its effect on rat tracheal epithelium. Lab Anim 10:93-104.
12. Gordon S, Tee RD, Lowson D, Wallace J, Newman Taylor AJ. 1992. Reduction of airborne allergenic urinary proteins from laboratory rats. Br J Ind Med 49:416-422.
13. Hasegawa M, Kagiyama S, Tajima M, Yoshida K, Minami Y, Kurosawa T. 2003. Evaluation of a forced-air-ventilated micro-isolation system for protection of mice against Pasteurella pneumotropica. Exp Anim 52:145-151. (Pubitemid 41349978)
14. Hext PM. 1994. Current perspectives on particulate induced pulmonary tumours. Hum Exp Toxicol 13:700-715.
15. Hinds WC. 1999. Aerosol technology: properties, behavior, and measurement of airborne particles. New York (NY): Wiley.
16. Hutchinson E, Avery A, Vandewoude S. 2005. Environmental enrichment for laboratory rodents. ILAR J 46:148-161.
17. Institute of Laboratory Animal Resources. 1996. Guide for the care and use of laboratory animals. Washington (DC): National Academies Press.
18. Ishii T, Yoshida K, Hasegawa M, Mizuno S, Okamoto M, Tajima M, Kurosawa T. 1998. Invention of a forced-air-ventilated microisolation cage and rack system, environment within cages: temperature and ammonia concentrations. Appl Anim Behav Sci 59:115-123. (Pubitemid 28422136)
19. Kacergis JB, Jones RB, Reeb CK, Turner WA, Ohman JL, Ardman MR, Paigen B. 1996. Air quality in an animal facility: particulates, ammonia, and volatile organic compounds. Am Ind Hyg Assoc J 57:634-640. (Pubitemid 126838820)
20. Langham GL, Hoyt RF, Johnson TE. 2006. Particulate matter in animal rooms housing mice in microisolation caging. J Am Assoc Lab Anim Sci 45:44-48.
21. Lipman NS. 1999. Isolator rodent caging systems (state of the art): a critical view. Contemp Top Lab Anim Sci 38:9-17.
22. Memarzadeh F, Harrison PC, Riskowski GL, Henze T. 2004. Comparison of environment and mice in static and mechanically ventilated isolator cages with different air velocities and ventilation designs. Contemp Top Lab Anim Sci 43:14-20. (Pubitemid 38114199)
23. Memarzadeh F, Manning A. 2005. Control of ammonia production in animal research facilities through ventilation system design. Am Soc Heat Refrig Air Cond Eng Trans 111:203-212.
24. Novak G. 1997. Individually ventilated microisolation cages. Lab Anim (NY) 26:54-57.
25. Percy DH, Barthold SW. 2007. Pathology of laboratory rodents and rabbits. Ames (IA): Blackwell.
26. Perkins SE, Lipman NS. 1995. Characterization and quantification of microenvironmental contaminants in isolator cages with a variety of contact beddings. Contemp Top Lab Anim Sci 34:93-98.
27. Perkins SE, Lipman NS. 1996. Evaluation of microenvironmental conditions and noise generation in 3 individually ventilated rodent caging systems and static isolator cages. Contemp Top Lab Anim Sci 35:61-65.
28. Platts-Mills J, Custis N, Kenney A, Tsay A, Chapman M, Feldman S, Platts-Mills T. 2005. The effects of cage design on airborne allergens and endotoxin in animal rooms: high-volume measurements with an ion-charging device. Contemp Top Lab Anim Sci 44:12-16.
29. Platts-Mills TA, Heymann PW, Longbottom JL, Wilkins SR. 1986. Airborne allergens associated with asthma: particle sizes carrying dust mite and rat allergens measured with a cascade impactor. J Allergy Clin Immunol 77:850-857.
30. Pope CA 3rd, Ezzati M, Dockery DW. 2009. Fine-particulate air pollution and life expectancy in the United States. N Engl J Med 360:376-386.
31. Reeb-Whitaker CK, Paigen B, Beamer WG, Bronson RT, Churchill GA, Schweitzer IB, Myers DD. 2001. The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages. Lab Anim 3558-3573
32. Reeb C, Jones R, Bearg D, Bedigan H, Myers D, Paigen B. 1998. Microenvironment in ventilated animal cages with differing ventilation rates, mice populations, and frequency of bedding changes. Contemp Top Lab Anim Sci 37:43-49. (Pubitemid 128531030)
33. Reed B, Hawkins P, Latham N, Westwood K, van Driel K, Battram C, Golledge H, Farmer AM, Osborne N, Jennings M, Hubrecht R. 2008. Report of the 2006 RSPCA/UFAW Rodent Welfare Group meeting. Lab Anim (NY) 37:216-222. (Pubitemid 351584915)
34. Rosenbaum M, VandeWoude S, Johnson TJ. 2009. Effects of cage-change frequency and bedding volume on mice and their microenvironment. J Am Assoc Lab Anim Sci..48:763-773.
35. Seward JP. 1999. Occupational allergy to animals. Occup Med 14:285-304.