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Volumn 10, Issue 4, 2011, Pages 91-98

Insights into HIV-1 pathogenesis through drug discovery: 30 years of basic research and concerns for the future

Author keywords

AIDS; Antiretroviral drugs; Drug resistance; HIV; Microbicides; Pre exposure prophylaxis

Indexed keywords

ADEFOVIR; ANTIRETROVIRUS AGENT; DIDANOSINE; EMTRICITABINE; LAMIVUDINE; MICROBICIDE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

EID: 83255187129     PISSN: 17301270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hivar.2011.09.003     Document Type: Review
Times cited : (7)

References (106)
  • 1
    • 0000888390 scopus 로고
    • Los Angeles, MMWR
    • CDC, Pneumocystis pneumonia - Los Angeles, MMWR (1981) 250-252.
    • (1981) CDC, Pneumocystis Pneumonia , pp. 250-252
  • 2
    • 0019774135 scopus 로고
    • An outbreak of community-acquired Pneumocystis carinii pneumonia. Initial manifestation of cellular immune dysfunction
    • H. Masur, M.A. Michelis, J.B. Greene, I. Onorato, R.A. Stouwe, R.S. Holzman, et al., An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction, N. Engl. J. Med. 305 (1981) 1431-1438. (Pubitemid 12240077)
    • (1981) New England Journal of Medicine , vol.305 , Issue.24 , pp. 1431-1438
    • Masur, H.1    Michelis, M.A.2    Greene, J.B.3
  • 3
    • 0019782357 scopus 로고
    • Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. Evidence of a new acquired cellular immunodeficiency
    • M.S. Gottlieb, R. Schroff, H.M. Schanker, J.D. Weisman, P.T. Fan, R.A. Wolf, et al., Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency, N. Engl. J. Med. 305 (1981) 1425-1431. (Pubitemid 12240076)
    • (1981) New England Journal of Medicine , vol.305 , Issue.24 , pp. 1425-1431
    • Gottlieb, M.S.1    Schroff, R.2    Schanker, H.M.3
  • 5
    • 49049133945 scopus 로고
    • Is sperm immunosuppressive in homosexuals and vasectomized men?
    • G.M.H. Shearer, U. Is sperm immunosuppressive in homosexuals and vasectomized men? Immunol. Today 3 (1982) 153-154.
    • (1982) Immunol Today , vol.3 , pp. 153-154
    • G, M.H.1    Shearer, U.2
  • 6
    • 0019846006 scopus 로고
    • Primary Pneumocystis carinii and cytomegalovirus infections
    • R.M. du Bois, M.A. Branthwaite, J.R. Mikhail, J.C. Batten, Primary Pneumocystis carinii and cytomegalovirus infections, Lancet 2 (1981) 1339. (Pubitemid 12180396)
    • (1981) Lancet , vol.2 , Issue.8259 , pp. 1339
    • Du Bois, R.M.1    Branthwaite, M.A.2    Mikhail, J.R.3    Batten, J.C.4
  • 7
    • 0037827948 scopus 로고
    • Kaposi's sarcoma (KS), Pneumocystis pneumonia (PCP), and other opportunistic infections (01): Case reported to CDC as of July 8th 1982
    • CDC, 513-514
    • CDC, Kaposi's sarcoma (KS), Pneumocystis pneumonia (PCP), and other opportunistic infections (01): case reported to CDC as of July 8th 1982, MMWR 31 (1982), 507-508, 513-514.
    • (1982) MMWR , vol.31 , pp. 507-508
  • 8
    • 0020478151 scopus 로고
    • Opportunistic infections and Kaposi's sarcome among Haitians in the United States
    • CDC, 360-361
    • CDC, Opportunistic infections and Kaposi's sarcome among Haitians in the United States, MMWR 31 (1982), 351-354, 360-361.
    • (1982) MMWR , vol.31 , pp. 351-354
  • 9
    • 0004792966 scopus 로고
    • Epidemiological notes and reports Pneumocystis carinii pneumonia among persons with hemophilia A
    • CDC
    • CDC, Epidemiological notes and reports Pneumocystis carinii pneumonia among persons with hemophilia A, MMWR (1982) 365-367.
    • (1982) MMWR , pp. 365-367
  • 10
    • 84967809425 scopus 로고
    • Epidemiological notes and reports immunodeficiency among female sexual partners of males with Aquired Immunodeficiency Syndrome
    • CDC
    • CDC, Epidemiological notes and reports immunodeficiency among female sexual partners of males with Aquired Immunodeficiency Syndrome, MMWR 31 (1983) 697-698.
    • (1983) MMWR , vol.31 , pp. 697-698
  • 11
    • 0021271028 scopus 로고
    • Acquired immunodeficiency syndrome in a heterosexual population in Zaire
    • P. Piot, T.C. Quinn, H. Taelman, F.M. Feinsod, K.B. Minlangu, O. Wobin, et al., Acquired immunodeficiency syndrome in a heterosexual population in Zaire, Lancet 2 (1984) 65-69. (Pubitemid 14085127)
    • (1984) Lancet , vol.2 , Issue.8394 , pp. 65-69
    • Piot, P.1    Taelman, H.2    Quinn, T.C.3
  • 12
    • 85030491009 scopus 로고
    • WHO acquired immune deficiency syndrome emergencies
    • Geneva
    • WHO, Acquired Immune Deficiency Syndrome Emergencies, Report of a WHO Meeting, 1983, Geneva.
    • (1983) Report of A WHO Meeting
  • 13
    • 84920234691 scopus 로고
    • Current trends prevention of acquired immune deficiency syndrome (AIDS): Report of interagency recommendations
    • CDC
    • CDC, Current trends prevention of Acquired Immune Deficiency Syndrome (AIDS): report of interagency recommendations, MMWR (1983) 101-103.
    • (1983) MMWR , pp. 101-103
  • 14
    • 0020596551 scopus 로고
    • Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
    • F. Barre-Sinoussi, J.C. Chermann, F. Rey, M.T. Nugeyre, S. Chamaret, J. Gruest, et al., Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS), Science 220 (1983) 868-871. (Pubitemid 13080157)
    • (1983) Science , vol.220 , Issue.4599 , pp. 868-871
    • Barre Sinoussi, F.1    Chermann, J.C.2    Rey, F.3
  • 15
    • 0021754949 scopus 로고
    • Strong new candidate for AIDS agent
    • J.L. Marx, Strong new candidate for AIDS agent, Science 224 (1984) 475-477.
    • (1984) Science , vol.224 , pp. 475-477
    • Marx, J.L.1
  • 16
    • 0021237243 scopus 로고
    • Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
    • M. Popovic, M.G. Sarngadharan, E. Read, R.C. Gallo, Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS, Science 224 (1984) 497-500. (Pubitemid 14134740)
    • (1984) Science , vol.224 , Issue.4648 , pp. 497-500
    • Popovic, M.1    Sarngadharan, M.G.2    Read, E.3    Gallo, R.C.4
  • 20
    • 0019254359 scopus 로고
    • Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
    • DOI 10.1073/pnas.77.12.7415
    • B.J. Poiesz, F.W. Ruscetti, A.F. Gazdar, P.A. Bunn, J.D. Minna, R.C. Gallo, Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proc. Natl. Acad. Sci. U. S. A. 77 (1980) 7415-7419. (Pubitemid 11131140)
    • (1980) Proceedings of the National Academy of Sciences of the United States of America , vol.77 , Issue.12 , pp. 7415-7419
    • Poiesz, B.J.1    Ruscetti, F.W.2    Gazdar, A.F.3
  • 21
  • 22
    • 0021234845 scopus 로고
    • Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS
    • M.G. Sarngadharan, M. Popovic, L. Bruch, J. Schupbach, R.C. Gallo, Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS, Science 224 (1984) 506-508. (Pubitemid 14134743)
    • (1984) Science , vol.224 , Issue.4648 , pp. 506-508
    • Sarngadharan, M.G.1    Popovic, M.2    Bruch, L.3
  • 23
    • 0022006221 scopus 로고
    • HTLV-III, LAV, ARV are variants of same AIDS virus
    • L. Ratner, R.C. Gallo, F. Wong-Staal, HTLV-III, LAV, ARV are variants of same AIDS virus, Nature 313 (1985) 636-637. (Pubitemid 15172464)
    • (1985) Nature , vol.313 , Issue.6004 , pp. 636-637
    • Ratner, L.1    Gallo, R.C.2    Wong-Staal, F.3
  • 24
    • 0022640412 scopus 로고
    • Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex
    • R. Yarchoan, R.W. Klecker, K.J. Weinhold, P.D. Markham, H.K. Lyerly, D.T. Durack, et al., Administration of 3-azido-3-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex, Lancet 1 (1986) 575-580. (Pubitemid 16138382)
    • (1986) Lancet , vol.1 , Issue.8481 , pp. 575-580
    • Yarchoan, R.1    Weinhold, K.J.2    Lyerly, H.K.3
  • 25
    • 0023268502 scopus 로고
    • The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial
    • M.A. Fischl, D.D. Richman, M.H. Grieco, M.S. Gottlieb, P.A. Volberding, O.L. Laskin, et al., The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial, N. Engl. J. Med. 317 (1987) 185-191. (Pubitemid 17114872)
    • (1987) New England Journal of Medicine , vol.317 , Issue.4 , pp. 185-191
    • Fischl, M.A.1    Richman, D.D.2    Grieco, M.H.3
  • 26
    • 0024508058 scopus 로고
    • HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
    • B.A. Larder, G. Darby, D.D. Richman, HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy, Science 243 (1989) 1731-1734. (Pubitemid 19106971)
    • (1989) Science , vol.243 , Issue.4899 , pp. 1731-1734
    • Larder, B.A.1    Darby, G.2    Richman, D.D.3
  • 27
    • 0024267430 scopus 로고
    • Fidelity of HIV-1 reverse transcriptase
    • B.D. Preston, B.J. Poiesz, L.A. Loeb, Fidelity of HIV-1 reverse transcriptase, Science 242 (1988) 1168-1171. (Pubitemid 19007042)
    • (1988) Science , vol.242 , Issue.4882 , pp. 1168-1171
    • Preston, B.D.1    Poiesz, B.J.2    Loeb, L.A.3
  • 28
    • 0024273119 scopus 로고
    • The accuracy of reverse transcriptase from HIV-1
    • J.D. Roberts, K. Bebenek, T.A. Kunkel, The accuracy of reverse transcriptase from HIV-1, Science 242 (1988) 1171-1173. (Pubitemid 19007043)
    • (1988) Science , vol.242 , Issue.4882 , pp. 1171-1173
    • Roberts, J.D.1    Bebenek, K.2    Kunkel, T.A.3
  • 29
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • B.A. Larder, S.D. Kemp, Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT), Science 246 (1989) 1155-1158. (Pubitemid 20012773)
    • (1989) Science , vol.246 , Issue.4934 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 32
    • 0014545828 scopus 로고
    • The enzymatic termination of polydeoxynucleotides by 2-,3- dideoxyadenosine triphosphate
    • L. Toji, S.S. Cohen, The enzymatic termination of polydeoxynucleotides by 2-,3-dideoxyadenosine triphosphate, Proc. Natl. Acad. Sci. U. S. A. 63 (1969) 871-877.
    • (1969) Proc. Natl. Acad. Sci. U. S. A , vol.63 , pp. 871-877
    • Toji, L.1    Cohen, S.S.2
  • 33
    • 0001707601 scopus 로고
    • 3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
    • DOI 10.1073/pnas.82.20.7096
    • H. Mitsuya, K.J. Weinhold, P.A. Furman, M.H. St Clair, S.N. Lehrman, R.C. Gallo, et al., 3-Azido-3-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro, Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 7096-7100. (Pubitemid 16209699)
    • (1985) Proceedings of the National Academy of Sciences of the United States of America , vol.82 , Issue.20 , pp. 7096-7100
    • Mitsuya, H.1    Weinhold, K.J.2    Furman, P.A.3
  • 34
    • 0026579394 scopus 로고
    • In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase
    • J.W. Mellors, G.E. Dutschman, G.J. Im, E. Tramontano, S.R. Winkler, Y.C. Cheng, In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase, Mol. Pharmacol. 41 (1992) 446-451.
    • (1992) Mol. Pharmacol , vol.41 , pp. 446-451
    • Mellors, J.W.1    Dutschman, G.E.2    Im, G.J.3    Tramontano, E.4    Winkler, S.R.5    Cheng, Y.C.6
  • 35
    • 0024706946 scopus 로고
    • Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity
    • B.A. Larder, S.D. Kemp, D.J. Purifoy, Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity, Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 4803-4807.
    • (1989) Proc. Natl. Acad. Sci. U. S. A , vol.86 , pp. 4803-4807
    • Larder, B.A.1    Kemp, S.D.2    Purifoy, D.J.3
  • 37
    • 0026042638 scopus 로고
    • Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture
    • B.A. Larder, K.E. Coates, S.D. Kemp, Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture, J. Virol. 65 (1991) 5232-5236.
    • (1991) J. Virol , vol.65 , pp. 5232-5236
    • Larder, B.A.1    Coates, K.E.2    Kemp, S.D.3
  • 39
    • 33947365160 scopus 로고    scopus 로고
    • The fitness cost of mutations associated with human immunodeficiency virus type 1 drug resistance is modulated by mutational interactions
    • DOI 10.1128/JVI.02712-06
    • M.E. Cong, W. Heneine, J.G. Garcia-Lerma, The fitness cost of mutations associated with human immunodeficiency virus type 1 drug resistance is modulated by mutational interactions, J. Virol. 81 (2007) 3037-3041. (Pubitemid 46447070)
    • (2007) Journal of Virology , vol.81 , Issue.6 , pp. 3037-3041
    • Cong, M.-E.1    Heneine, W.2    Garcia-Lerma, J.G.3
  • 40
    • 0029798237 scopus 로고    scopus 로고
    • Nevirapine-resistant human immunodeficiency virus: Kinetics of replication and estimated prevalence in untreated patients
    • D.V. Havlir, S. Eastman, A. Gamst, D.D. Richman, Nevirapine-resistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients, J. Virol. 70 (1996) 7894-7899. (Pubitemid 26339097)
    • (1996) Journal of Virology , vol.70 , Issue.11 , pp. 7894-7899
    • Havlir, D.V.1    Eastman, S.2    Gamst, A.3    Richman, D.D.4
  • 42
    • 0033816265 scopus 로고    scopus 로고
    • Identification of the K103N resistance mutation in Ugandan women receiving nevirapine to prevent HIV-1 vertical transmission
    • J.B. Jackson, G. Becker-Pergola, L.A. Guay, P. Musoke, M. Mracna, M.G. Fowler, et al., Identification of the K103N resistance mutation in Ugandan women receiving nevirapine to prevent HIV-1 vertical transmission, AIDS 14 (2000) F111-F115.
    • (2000) AIDS , vol.14
    • Jackson, J.B.1    Becker-Pergola, G.2    Guay, L.A.3    Musoke, P.4    Mracna, M.5    Fowler, M.G.6
  • 44
    • 0001587762 scopus 로고
    • Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides
    • H. Mitsuya, S. Broder, Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy- associated virus (HTLV-III/LAV) by 2-,3-dideoxynucleosides, Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 1911-1915. (Pubitemid 16018673)
    • (1986) Proceedings of the National Academy of Sciences of the United States of America , vol.83 , Issue.6 , pp. 1911-1915
    • Mitsuya, H.1    Broder, S.2
  • 47
    • 0025138304 scopus 로고
    • Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay
    • B.A. Larder, B. Chesebro, D.D. Richman, Susceptibilities of zidovudinesusceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay, Antimicrob. Agents Chemother. 34 (1990) 436-441. (Pubitemid 20068667)
    • (1990) Antimicrobial Agents and Chemotherapy , vol.34 , Issue.3 , pp. 436-441
    • Larder, B.A.1    Chesebro, B.2    Richman, D.D.3
  • 48
    • 0025825089 scopus 로고
    • Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: Susceptibility and resistance to other drugs
    • R. Rooke, M.A. Parniak, M. Tremblay, H. Soudeyns, X.G. Li, Q. Gao, et al., Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs, Antimicrob. Agents Chemother. 35 (1991) 988-991.
    • (1991) Antimicrob. Agents Chemother , vol.35 , pp. 988-991
    • Rooke, R.1    Parniak, M.A.2    Tremblay, M.3    Soudeyns, H.4    Li, X.G.5    Gao, Q.6
  • 50
    • 0001344128 scopus 로고
    • Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro
    • DOI 10.1073/pnas.84.7.2033
    • H. Mitsuya, R.F. Jarrett, M. Matsukura, F. Di Marzo Veronese, A.L. DeVico, M.G. Sarngadharan, et al., Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2-,3- dideoxynucleosides in vitro, Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 2033-2037. (Pubitemid 17054144)
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.7 , pp. 2033-2037
    • Mitsuya, H.1    Jarrett, R.F.2    Matsukura, M.3
  • 51
    • 0023837875 scopus 로고
    • Phase i studies of 2-,3-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT)
    • R. Yarchoan, C.F. Perno, R.V. Thomas, R.W. Klecker, J.P. Allain, R.J. Wills, et al., Phase I studies of 2-,3-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT), Lancet 1 (1988) 76-81.
    • (1988) Lancet , vol.1 , pp. 76-81
    • Yarchoan, R.1    Perno, C.F.2    Thomas, R.V.3    Klecker, R.W.4    Allain, J.P.5    Wills, R.J.6
  • 52
    • 0024332803 scopus 로고
    • Human immunodeficiency virus inhibition is prolonged by 3'-azido-3'-deoxythymidine alternating with 2',3'-dideoxycytidine compared with 3'-azido-3'-deoxythymidine alone
    • S.A. Spector, D. Ripley, K. Hsia, Human immunodeficiency virus inhibition is prolonged by 3-azido-3-deoxythymidine alternating with 2-,3-dideoxycytidine compared with 3-azido-3-deoxythymidine alone, Antimicrob. Agents Chemother. 33 (1989) 920-923. (Pubitemid 19146584)
    • (1989) Antimicrobial Agents and Chemotherapy , vol.33 , Issue.6 , pp. 920-923
    • Spector, S.A.1    Ripley, D.2    Hsia, K.3
  • 53
    • 0023636684 scopus 로고
    • Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro
    • M. Baba, R. Pauwels, J. Balzarini, P. Herdewijn, E. De Clercq, J. Desmyter, Ribavirin antagonizes inhibitory effects of pyrimidine 2-,3-dideoxynucleosides but enhances inhibitory effects of purine 2-,3-dideoxynucleosides on replication of human immunodeficiency virus in vitro, Antimicrob. Agents Chemother. 31 (1987) 1613-1617. (Pubitemid 17140823)
    • (1987) Antimicrobial Agents and Chemotherapy , vol.31 , Issue.10 , pp. 1613-1617
    • Baba, M.1    Pauwels, R.2    Balzarini, J.3
  • 54
    • 0026513969 scopus 로고
    • Combination therapy with zidovudine and dideoxycytidine in patients with advanced human immunodeficiency virus infection. A phase I/II study
    • T.C. Meng, M.A. Fischl, A.M. Boota, S.A. Spector, D. Bennett, Y. Bassiakos, et al., Combination therapy with zidovudine and dideoxycytidine in patients with advanced human immunodeficiency virus infection. A phase I/II study, Ann. Intern. Med. 116 (1992) 13-20.
    • (1992) Ann. Intern. Med , vol.116 , pp. 13-20
    • Meng, T.C.1    Fischl, M.A.2    Boota, A.M.3    Spector, S.A.4    Bennett, D.5    Bassiakos, Y.6
  • 55
    • 0028137794 scopus 로고
    • Resistance to AZT and ddC during long-term combination therapy in patients with advanced infection with human immunodeficiency virus
    • D.D. Richman, T.C. Meng, S.A. Spector, M.A. Fischl, L. Resnick, S. Lai, Resistance to AZT and ddC during long-term combination therapy in patients with advanced infection with human immunodeficiency virus, J. Acquir. Immune Defic. Syndr. 7 (1994) 135-138. (Pubitemid 24052347)
    • (1994) Journal of Acquired Immune Deficiency Syndromes , vol.7 , Issue.2 , pp. 135-138
    • Richman, D.D.1    Meng, T.-C.2    Spector, S.A.3    Fischl, M.A.4    Resnick, L.5    Lai, S.6
  • 56
    • 0029836432 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 drug susceptibility during zidovudine (AZT) monotherapy compared with AZT plus 2',3'-dideoxyinosine or AZT plus 2',3'-dideoxycytidine combination therapy
    • B.A. Larder, A. Kohli, S. Bloor, S.D. Kemp, P.R. Harrigan, R.T. Schooley, et al., Human immunodeficiency virus type 1 drug susceptibility during zidovudine (AZT) monotherapy compared with AZT plus 2-,3-dideoxyinosine or AZT plus 2-,3-dideoxycytidine combination therapy. The protocol 34,225-02 Collaborative Group, J. Virol. 70 (1996) 5922-5929. (Pubitemid 26266805)
    • (1996) Journal of Virology , vol.70 , Issue.9 , pp. 5922-5929
    • Larder, B.A.1    Kohli, A.2    Bloor, S.3    Kemp, S.D.4    Harrigan, P.R.5    Schooley, R.T.6    Lange, J.M.A.7    Pennington, K.N.8    St. Clair, M.H.9
  • 58
    • 0030070991 scopus 로고    scopus 로고
    • Prognosis in HIV-1 infection predicted by the quantity of virus in plasma
    • J.W. Mellors, C.R. Rinaldo Jr., P. Gupta, R.M. White, J.A. Todd, L.A. Kingsley, Prognosis in HIV-1 infection predicted by the quantity of virus in plasma, Science 272 (1996) 1167-1170. (Pubitemid 26001148)
    • (1996) Science , vol.272 , Issue.5265 , pp. 1167-1170
    • Mellors, J.W.1    Rinaldo Jr., C.R.2    Gupta, P.3    White, R.M.4    Todd, J.A.5    Kingsley, L.A.6
  • 59
    • 0027155374 scopus 로고
    • The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high- level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine
    • Q. Gao, Z. Gu, M.A. Parniak, J. Cameron, N. Cammack, C. Boucher, et al., The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2-,3-dideoxyinosine and 2-,3-dideoxycytidine confers high-level resistance to the (?) enantiomer of 2-,3-dideoxy-3-thiacytidine, Antimicrob. Agents Chemother. 37 (1993) 1390-1392. (Pubitemid 23166750)
    • (1993) Antimicrobial Agents and Chemotherapy , vol.37 , Issue.6 , pp. 1390-1392
    • Gao, Q.1    Gu, Z.2    Parniak, M.A.3    Cameron, J.4    Cammack, N.5    Boucher, C.6    Wainberg, M.A.7
  • 60
    • 0029024089 scopus 로고
    • Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)
    • R. Schuurman, M. Nijhuis, R. van Leeuwen, P. Schipper, D. de Jong, P. Collis, et al., Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC), J. Infect. Dis. 171 (1995) 1411-1419.
    • (1995) J. Infect. Dis , vol.171 , pp. 1411-1419
    • Schuurman, R.1    Nijhuis, M.2    Van Leeuwen, R.3    Schipper, P.4    De Jong, D.5    Collis, P.6
  • 61
    • 0026465275 scopus 로고
    • Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2-,3-dideoxyinosine and 2-,3-dideoxycytidine
    • Z. Gu, Q. Gao, X. Li, M.A. Parniak, M.A. Wainberg, Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2-,3-dideoxyinosine and 2-,3-dideoxycytidine, J. Virol. 66 (1992) 7128-7135.
    • (1992) J. Virol , vol.66 , pp. 7128-7135
    • Gu, Z.1    Gao, Q.2    Li, X.3    Parniak, M.A.4    Wainberg, M.A.5
  • 62
    • 0027285372 scopus 로고
    • Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
    • M. Tisdale, S.D. Kemp, N.R. Parry, B.A. Larder, Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase, Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 5653-5656. (Pubitemid 23176219)
    • (1993) Proceedings of the National Academy of Sciences of the United States of America , vol.90 , Issue.12 , pp. 5653-5656
    • Tisdale, M.1    Kemp, S.D.2    Parry, N.R.3    Larder, B.A.4
  • 64
    • 33750479074 scopus 로고    scopus 로고
    • The M184V mutation: What it does, how to prevent it, and what to do with it when it's there
    • J.E. Gallant, The M184V mutation: what it does, how to prevent it, and what to do with it when it's there, AIDS Read. 16 (2006) 556-559. (Pubitemid 44646033)
    • (2006) AIDS Reader , vol.16 , Issue.10 , pp. 556-559
    • Gallant, J.E.1
  • 65
    • 0022546859 scopus 로고
    • HTLV-III gag protein is processed in yeast cells by the virus pol-protease
    • R.A. Kramer, M.D. Schaber, A.M. Skalka, K. Ganguly, F. Wong-Staal, E.P. Reddy, HTLV-III gag protein is processed in yeast cells by the virus pol-protease, Science 231 (1986) 1580-1584. (Pubitemid 16050731)
    • (1986) Science , vol.231 , Issue.4745 , pp. 1580-1584
    • Kramer, R.A.1    Schaber, M.D.2    Skalka, A.M.3
  • 66
    • 0023992802 scopus 로고
    • An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity
    • M.C. Graves, J.J. Lim, E.P. Heimer, R.A. Kramer, An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity, Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 2449-2453.
    • (1988) Proc. Natl. Acad. Sci. U. S. A , vol.85 , pp. 2449-2453
    • Graves, M.C.1    Lim, J.J.2    Heimer, E.P.3    Kramer, R.A.4
  • 68
    • 0024063076 scopus 로고
    • Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation
    • S.F. Le Grice, J. Mills, J. Mous, Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation, EMBO J. 7 (1988) 2547-2553.
    • (1988) EMBO J , vol.7 , pp. 2547-2553
    • Le Grice, S.F.1    Mills, J.2    Mous, J.3
  • 69
    • 0023783663 scopus 로고
    • Characterization of human immunodeficiency virus gag/pol gene products expressed by recombinant vaccinia viruses
    • C. Flexner, S.S. Broyles, P. Earl, S. Chakrabarti, B. Moss, Characterization of human immunodeficiency virus gag/pol gene products expressed by recombinant vaccinia viruses, Virology 166 (1988) 339-349.
    • (1988) Virology , vol.166 , pp. 339-349
    • Flexner, C.1    Broyles, S.S.2    Earl, P.3    Chakrabarti, S.4    Moss, B.5
  • 71
    • 0026515142 scopus 로고
    • Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: Posttranslational modifications, proteolytic processings, and complete amino acid sequences
    • L.E. Henderson, M.A. Bowers, R.C. Sowder 2nd, S.A. Serabyn, D.G. Johnson, J.W. Bess Jr., et al., Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequences, J. Virol. 66 (1992) 1856-1865.
    • (1992) J. Virol , vol.66 , pp. 1856-1865
    • Henderson, L.E.1    Bowers, M.A.2    Sowder, R.C.3    Serabyn, S.A.4    Johnson, D.G.5    Bess Jr., J.W.6
  • 72
    • 0026579208 scopus 로고
    • The HIV-1 protease as a therapeutic target for AIDS AIDS Res. Hum
    • C. Debouck, The HIV-1 protease as a therapeutic target for AIDS, AIDS Res. Hum. Retroviruses 8 (1992) 153-164.
    • (1992) Retroviruses , vol.8 , pp. 153-164
    • Debouck, C.1
  • 73
    • 0025005794 scopus 로고
    • Effect of two novel inhibitors of the human immunodeficiency virus protease on the maturation of the HIV gag and gag-pol polyproteins
    • DOI 10.1016/0042-6822(90)90326-M
    • H.A. Overton, D.J. McMillan, S.J. Gridley, J. Brenner, S. Redshaw, J.S. Mills, Effect of two novel inhibitors of the human immunodeficiency virus protease on the maturation of the HIV gag and gag-pol polyproteins, Virology 179 (1990) 508-511. (Pubitemid 20354368)
    • (1990) Virology , vol.179 , Issue.1 , pp. 508-511
    • Overton, H.A.1    McMillan, D.J.2    Gridley, S.J.3    Brenner, J.4    Redshaw, S.5    Mills, J.S.6
  • 77
    • 0028013171 scopus 로고
    • Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor
    • M.A. el-Farrash, M.J. Kuroda, T. Kitazaki, T. Masuda, K. Kato, M. Hatanaka, et al., Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor, J. Virol. 68 (1994) 233-239.
    • (1994) J. Virol , vol.68 , pp. 233-239
    • El-Farrash, M.A.1    Kuroda, M.J.2    Kitazaki, T.3    Masuda, T.4    Kato, K.5    Hatanaka, M.6
  • 80
    • 0029838243 scopus 로고    scopus 로고
    • Mutations in retroviral genes associated with drug resistance
    • R.F. Schinazi, B.A. Larder, J.W. Mellors, Mutations in retroviral genes associated with drug resistance, in: International Antiviral News, International Medical Press, 1996, pp. 95-107. (Pubitemid 26340526)
    • (1996) International Antiviral News , vol.4 , Issue.6 , pp. 95-107
    • Schinazi, R.F.1    Larder, B.A.2    Mellors, J.W.3
  • 85
    • 0029095483 scopus 로고
    • Time to hit HIV early and hard
    • D.D. Ho, Time to hit HIV early and hard, N. Engl. J. Med. 333 (1995) 450-451.
    • (1995) N. Engl. J. Med , vol.333 , pp. 450-451
    • Ho, D.D.1
  • 87
    • 64349118898 scopus 로고    scopus 로고
    • Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: A collaborative analysis of 18 HIV cohort studies
    • J.A. Sterne, M. May, D. Costagliola, F. de Wolf, A.N. Phillips, R. Harris, et al., Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies, Lancet 373 (2009) 1352-1363.
    • (2009) Lancet , vol.373 , pp. 1352-1363
    • Sterne, J.A.1    May, M.2    Costagliola, D.3    De Wolf, F.4    Phillips, A.N.5    Harris, R.6
  • 89
    • 59249096215 scopus 로고    scopus 로고
    • Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1
    • R.E. Haaland, P.A. Hawkins, J. Salazar-Gonzalez, A. Johnson, A. Tichacek, E. Karita, et al., Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1, PLoS Pathog. 5 (2009) e1000274.
    • (2009) PLoS Pathog , vol.5
    • Haaland, R.E.1    Hawkins, P.A.2    Salazar-Gonzalez, J.3    Johnson, A.4    Tichacek, A.5    Karita, E.6
  • 90
    • 64049089430 scopus 로고    scopus 로고
    • Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants
    • M.R. Abrahams, J.A. Anderson, E.E. Giorgi, C. Seoighe, K. Mlisana, L.H. Ping, et al., Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants, J. Virol. 83 (2009) 3556-3567.
    • (2009) J. Virol , vol.83 , pp. 3556-3567
    • Abrahams, M.R.1    Anderson, J.A.2    Giorgi, E.E.3    Seoighe, C.4    Mlisana, K.5    Ping, L.H.6
  • 91
    • 0027422278 scopus 로고
    • Genotypic and phenotypic characterization of HIV-1 in patients with primary infection
    • T. Zhu, H. Mo, N. Wang, D.S. Nam, Y. Cao, R.A. Koup, et al., Genotypic and phenotypic characterization of HIV-1 patients with primary infection, Science 261 (1993) 1179-1181. (Pubitemid 23300886)
    • (1993) Science , vol.261 , Issue.5125 , pp. 1179-1181
    • Zhu, T.1    Mo, H.2    Wang, N.3    Nam, D.S.4    Cao, Y.5    Koup, R.A.6    Ho, D.D.7
  • 92
    • 0027229245 scopus 로고
    • Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection
    • L.Q. Zhang, P. MacKenzie, A. Cleland, E.C. Holmes, A.J. Brown, P. Simmonds, Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection, J. Virol. 67 (1993) 3345-3356. (Pubitemid 23143709)
    • (1993) Journal of Virology , vol.67 , Issue.6 , pp. 3345-3356
    • Zhang, L.Q.1    MacKenzie, P.2    Cleland, A.3    Holmes, E.C.4    Brown, A.J.L.5    Simmonds, P.6
  • 93
    • 0026552401 scopus 로고
    • Rapid generation of sequence variation during primary HIV-1 infection
    • S. Pang, Y. Shlesinger, E.S. Daar, T. Moudgil, D.D. Ho, I.S. Chen, Rapid generation of sequence variation during primary HIV-1 infection, AIDS 6 (1992) 453-460.
    • (1992) AIDS , vol.6 , pp. 453-460
    • Pang, S.1    Shlesinger, Y.2    Daar, E.S.3    Moudgil, T.4    Ho, D.D.5    Chen, I.S.6
  • 94
    • 0036888937 scopus 로고    scopus 로고
    • Virus population homogenization following acute human immunodeficiency virus type 1 infection
    • DOI 10.1128/JVI.76.23.11953-11959.2002
    • G.H. Learn, D. Muthui, S.J. Brodie, T. Zhu, K. Diem, J.I. Mullins, et al., Virus population homogenization following acute human immunodeficiency virus type 1 infection, J. Virol. 76 (2002) 11953-11959. (Pubitemid 35304295)
    • (2002) Journal of Virology , vol.76 , Issue.23 , pp. 11953-11959
    • Learn, G.H.1    Muthui, D.2    Brodie, S.J.3    Zhu, T.4    Diem, K.5    Mullins, J.I.6    Corey, L.7
  • 95
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Q. Abdool Karim, S.S. Abdool Karim, J.A. Frohlich, A.C. Grobler, C. Baxter, L.E. Mansoor, et al., Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women, Science 329 (2010) 1168-1174.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3    Grobler, A.C.4    Baxter, C.5    Mansoor, L.E.6
  • 96
    • 23244454080 scopus 로고    scopus 로고
    • The global status of resistance to antiretroviral drugs
    • DOI 10.1086/430784
    • S. Vella, L. Palmisano, The global status of resistance to antiretroviral drugs, Clin. Infect. Dis. 41 (Suppl. 4) (2005) S239-S246. (Pubitemid 41099618)
    • (2005) Clinical Infectious Diseases , vol.41 , Issue.4 SUPPL.
    • Vella, S.1    Palmisano, L.2
  • 99
    • 80051785649 scopus 로고    scopus 로고
    • Synergy against drug resistant HIV-1 with the microbicide antiretrovirals, dapivirine and tenofovir, in combination
    • S.M. Schader, S.P. Colby-Germinario, J.R. Schachter, H. Xu, M.A. Wainberg, Synergy against drug resistant HIV-1 with the microbicide antiretrovirals, dapivirine and tenofovir, in combination, AIDS 25 (2011) 1585-1594.
    • (2011) AIDS , vol.25 , pp. 1585-1594
    • Schader, S.M.1    Colby-Germinario, S.P.2    Schachter, J.R.3    Xu, H.4    Wainberg, M.A.5
  • 101
    • 39849100140 scopus 로고    scopus 로고
    • Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir
    • J.G. Garcia-Lerma, R.A. Otten, S.H. Qari, E. Jackson, M.E. Cong, S. Masciotra, et al., Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir, PLoS Med. 5 (2008) e28.
    • (2008) PLoS Med , vol.5
    • Garcia-Lerma, J.G.1    Otten, R.A.2    Qari, S.H.3    Jackson, E.4    Cong, M.E.5    Masciotra, S.6
  • 103
    • 55249126356 scopus 로고    scopus 로고
    • Drug-susceptible HIV-1 infection despite intermittent fixed-dose combination tenofovir/emtricitabine as prophylaxis is associated with low-level viremia, delayed seroconversion, and an attenuated clinical course
    • N. Prada, B. Davis, P. Jean-Pierre, M. La Roche, F.M. Duh, M. Carrington, et al., Drug-susceptible HIV-1 infection despite intermittent fixed-dose combination tenofovir/emtricitabine as prophylaxis is associated with low-level viremia, delayed seroconversion, and an attenuated clinical course, J. Acquir. Immune Defic. Syndr. 49 (2008) 117-122.
    • (2008) J. Acquir. Immune Defic. Syndr , vol.49 , pp. 117-122
    • Prada, N.1    Davis, B.2    Jean-Pierre, P.3    La Roche, M.4    Duh, F.M.5    Carrington, M.6
  • 104
    • 79954559071 scopus 로고    scopus 로고
    • Factors influencing the emergence and spread of HIV drug resistance arising from rollout of antiretroviral pre-exposure prophylaxis (PrEP)
    • U.L. Abbas, G. Hood, A.W. Wetzel, J.W. Mellors, Factors influencing the emergence and spread of HIV drug resistance arising from rollout of antiretroviral pre-exposure prophylaxis (PrEP), PLoS One 6 (2011) e18165.
    • (2011) PLoS One , vol.6
    • Abbas, U.L.1    Hood, G.2    Wetzel, A.W.3    Mellors, J.W.4
  • 105
    • 65649135069 scopus 로고    scopus 로고
    • Circulating HIV type 1 drug resistance will have limited impact on the effectiveness of preexposure prophylaxis among young women
    • D.A. van de Vijver, I. Derdelinckx, C.A. Boucher, Circulating HIV, type 1 drug resistance will have limited impact on the effectiveness of preexposure prophylaxis among young women in Zimbabwe, J. Infect. Dis. 199 (2009) 1310-1317.
    • (2009) Zimbabwe J. Infect. Dis , vol.199 , pp. 1310-1317
    • De Van Vijver, D.A.1    Derdelinckx, I.2    Boucher, C.A.3


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