Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma

Journal of Cosmetic Dermatology

Volumn 10, Issue 4, 2011, Pages 282-287

  Farshi, Susan ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Azelaic acid; Hydroquinone; Melasma

Indexed keywords

AZELAIC ACID; HYDROQUINONE; SUNSCREEN;

ADULT; ARTICLE; CHLOASMA; CLINICAL ARTICLE; CREAM; DRUG EFFICACY; FEMALE; HUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; ULTRAVIOLET RADIATION;

ADULT; ANTIOXIDANTS; DERMATOLOGIC AGENTS; DICARBOXYLIC ACIDS; EMOLLIENTS; FEMALE; HUMANS; HYDROQUINONES; MELANOSIS; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 83255170491     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2011.00580.x     Document Type: Article

References (24)

1. Prignano F, Ortonne JP, Buggiani G et al. Therapeutical approaches in melasma. Dermatol Clin 2007; 25: 337-42 viii.
2. Pandya A, Berneburg M, Ortonne JP et al. Guidelines for clinical trials in melasma. Pigmentation Disorders Academy. Br J Dermatol 2006; 156(Suppl. 1): 21-8.
3. Victor FC, Gelber J, Rao B. Melasma: a review. J Cutan Med Surg 2004; 8: 97-102.
4. Lee MH, Kim HJ, Ha DJ et al. Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients. J Korean Med Sci 2002; 17: 518-23.
5. Rendon M, Berneburg M, Arellano I et al. Treatment of melasma. J Am Acad Dermatol 2006; 54: S272-81.
6. Lynde CB, Kraft JN, Lynde CW. Topical treatments for melasma and postinflammatory hyperpigmentation. Skin Therapy Lett 2006; 11: 1-6.
7. Espinal-Perez LE, Moncada B, Castanedo-Cazares JP. A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma. Int J Dermatol 2004; 43: 604-7.
8. Bandyopadhyay D. Topical treatment of melasma. Indian J Dermatol 2009; 54: 303-9.
9. Hacker SM. Common disorders of pigmentation: when are more than cosmetic cover-ups required? Postgrad Med 1996; 99: 177-86.
10. Gupta AK, Gover MD, Nouri K et al. The treatment of melasma: a review of clinical trials. J Am Acad Dermatol 2006; 55: 1048-65.
11. Nazzaro-Porro M. The use of azelaic acid in hyperpigmentation. Rev Contemp Pharmacother 1993; 4: 415-23.
12. Palumbo A, d'Ischia M, Misuraca G et al. Mechanism of inhibition of melanogenesis by hydroquinone. Biochim Biophys Acta 1991; 1073: 85-90.
13. Kakita LS, Lowe NJ. Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. Clin Ther 1998; 20: 960-70.
14. Camarasa JG, Serra-Baldrich E. Exogenous ochronosis with allergic contact dermatitis from hydroquinone. Contact Dermatitis 1994; 31: 57-8.
15. Fitton A, Goa KL. Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs 1991; 41: 780-98.
16. Breathnach AS. Azelaic acid in clinical medicine: an historical overview. Rev Contemp Pharmacother 1993; 4: 395-401.
17. Pandya AG, Hynan LS, Bhore R et al. Reliability assessment and validation of the Melasma Area and Severity Index (MASI) and a new modified MASI scoring method. J Am Acad Dermatol 2011; 64: 78-83.
18. Kimbrough-Green CK, Griffiths CE, Finkel LJ et al. Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial. Arch Dermatol 1994; 130: 727-33.
19. Jimbow K. N-acetyl-4-S-cysteaminylphenol as a new type of depigmenting agent for the melanoderma of patients with melasma. Arch Dermatol 1991; 127: 1528-34.
20. Rajaratnam R, Halpern J, Salim A et al. Interventions for melasma. Cochrane Database Syst Rev 2010; Jul 7;(7): CD003583.
21. Erbil H, Sezer E, Tastan B et al. Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. J Dermatol 2007; 34: 25-30.
22. Galhaup I. Azelaic acid: mode of action at cellular and subcellular levels. Acta Derm Venereol Suppl (Stockh) 1989; 143: 75-82.
23. Verallo-Rowell VM, Verallo V, Graupe K et al. Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. Acta Derm Venereol Suppl (Stockh) 1989; 143: 58-61.
24. Balina LM, Graupe K. The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. Int J Dermatol 1991; 30: 893-5.